Simultaneous in vivo positron emission tomography and magnetic resonance imaging
- Ciprian Catana*,†,
- Daniel Procissi‡,
- Yibao Wu*,
- Martin S. Judenhofer§,
- Jinyi Qi*,
- Bernd J. Pichler§,
- Russell E. Jacobs‡, and
- Simon R. Cherry*
- *Department of Biomedical Engineering, University of California, Genome and Biomedical Sciences Facility, 451 East Health Sciences Drive, Davis, CA 95616;
- ‡Beckman Institute, California Institute of Technology, MC 139-74, 1200 East California Boulevard, Pasadena, CA 91125; and
- §Department of Radiology, Laboratory for Preclinical Imaging and Imaging Technology, University of Tübingen, Roentgenweg 11, 72076 Tübingen, Germany
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Communicated by Michael E. Phelps, University of California School of Medicine, Los Angeles, CA, December 11, 2007 (received for review May 15, 2007)
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Fig. 1.MR scanner effect on PET system. (A–C) Detector histograms showing the anticlockwise (A) and clockwise (B) rotations of the crystal maps when compared with the data acquired outside of the magnet (C). (D) PET event rate measured under different conditions: (i) while applying only RF power (with 1,000 ms and 500 ms repetition times) and (ii) while switching the x–z gradients independently (at 100% and 50% power; 400 and 200 mT/m, respectively). Baseline represents the event rate recorded without running MR sequences.
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Fig. 2.PET insert effects on MR imaging. (A and B) SE (A) and GE (B) images of a structured phantom acquired in the presence of the PET insert. (C and D) SNR (C) and uniformity (D) measured for several pulse sequences with and without the PET insert, using a uniform phantom.
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Fig. 3.Simultaneous in vivo PET and MR imaging. (A) Mouse FDG tumor imaging. (Upper Left) PET image, (Upper Right) MR image, and (Lower) fused PET and MR image. One transaxial image slice is shown. (B) Fused PET and MR images of a mouse. Transaxial sections from top of head to bladder are shown. (Scale bars, 5 mm.) The same false-color look-up table is used in both A and B.
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Fig. 4.Advanced MR measurements. (A) In vivo MR spectroscopy; mouse 1H brain spectrum acquired in the presence of the PET insert. (B) ADC map of an in vivo mouse brain acquired by using a four-shot EPI sequence in the presence of the PET insert. ADC units are 10−3 mm2/sec. (Scale bar, 2 mm.)
Footnotes
- †To whom correspondence should be addressed at: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Building 149, Room 2301, 13th Street, Charlestown, MA 02129. E-mail: ccatana{at}nmr.mgh.harvard.edu
- © 2008 by The National Academy of Sciences of the USA
