Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection

Butcher and Schreiber. 10.1073/pnas.0402317101.

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Supporting Figure 6

Fig. 6. Key genes up-regulated by suppressor of FK506 (SFK)2 under conditions of 0.7 M NaCl plus 125 nM FK506. ACS1, encoding acetyl-CoA synthetase, converts the acetate generated by aldehyde dehydrogenase to acetyl-CoA. POT1 (3-ketoacyl-CoA thiolase), POX1 (acyl-CoA oxidase), FAA2 (acyl-CoA synthetase), FOX2 (multifunctional), ECI1 (D3,D2-enoyl-CoA isomerase), and DCI1 (D3,5,D2,4-dienoyl-CoA isomerase) all participate in the b-oxidation of fatty acids to acetyl-CoA.

This Article

  1. Published online before print May 14, 2004, doi: 10.1073/pnas.0402317101 PNAS May 25, 2004 vol. 101 no. 21 7868-7873
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