The cAMP binding domain: An ancient signaling module

Berman et al. 10.1073/pnas.0408579102.

Supporting Information

Files in this Data Supplement:

Supporting Table 1
Supporting Table 2
Supporting Table 3
Supporting Figure 8

Fig. 8. Affinity grids for four cAMP-protein structures. The cAMP is shown in ball-and-stick representation, but the protein structure is not shown for clarity. Contours are drawn at a level of -0.4 kcal/mol for carbon atoms (Left in white) and oxygen/nitrogen atoms (Right in red). The hydrogen affinity is not included, because it showed no features at this contour level. The structures are RIIb (A) (a), RIIb (B) (b), CAP (c), and HCN (d).

Table 1. cAMP-containing crystal structures: CAP

1. Passner, J. M. & Steitz, T. A. (1997) Proc. Natl. Acad. Sci. USA 94, 2843-2847.

2. Schultz, S. C., Shields, G. C. & Steitz, T. A. (1991) Science 253, 1001-1007.

3. Chen, S., Vojtechovsky, J., Parkinson, G. N., Ebright, R. H. & Berman, H. M. (2001) J. Mol. Biol. 314, 63-74.

4. Parkinson, G., Wilson, C., Gunasekera, A., Ebright, Y. W., Ebright, R. E. & Berman, H. M. (1996) J. Mol. Biol. 260, 395-408.

5. Parkinson, G., Gunasekera, A., Vojtechovsky, J., Zhang, X., Kunkel, T. A., Berman, H. M. & Ebright, R. H. (1996) Nat. Struct. Biol. 3, 837-841.

6. Chen, S., Gunasekera, A., Zhang, X., Ebright, R. H. & Berman, H. M. (2001) J. Mol. Biol. 314, 75-82.

7. Benoff, B., Yang, H., Lawson, C., Parkinson, G., Liu, J., Blatter, E., Ebright, Y. W., Berman, H. M. & Ebright, R. H. (2002) Science 297, 1562-1566.

8. Passner, J. M., Schultz, S. C. & Steitz, T. A. (2000) J. Mol. Biol. 304, 847-859.

9. Chu, S. Y., Tordova, M., Gilliland, G. L., Gorshkova, I., Shi, Y., Wang, S. & Schwarz, F. P. (2001) J. Biol. Chem. 276, 11230-11236.

Table 2. cAMP-containing crystal structures: PKA regulatory subunits

1. Diller, T. C., Madhusudan, Xuong, N. H. & Taylor, S. S. (2001) Structure (Camb) 9, 73-82.

2. Wu, J., Jones, J. M., Nguyen-Huu, X., Ten Eyck, L. F. & Taylor, S. S. (2004) Biochemistry 43, 6620-6629.

3. Su, Y., Dostmann, W. R., Herberg, F. W., Durick, K., Xuong, N. H., Ten Eyck, L., Taylor, S. S. & Varughese, K. I. (1995) Science 269, 807-813.

Table 3. cAMP-containing crystal structures: HCN

 

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