Organically modified silica nanoparticles: A nonviral vector for in vivo gene delivery and expression in the brain

Bharali et al. 10.1073/pnas.0504926102.

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Supporting Movie 1

Movie 1. Monitoring transfected cells in vivo. In vivo imaging of EGFP fluorescence in cells in the lateral ventricle. Ten days after transfection of organically modified silica/pEGFP-N2, mice were subjected to the second stereotaxic surgery, and a miniature fiber-optic probe (350-mm tip; Cell-viZio, Discovery Technology, Sarasota, FL) was inserted into the anterior dorsal region of the lateral ventricle >15 mm from the medial ventricular wall. Dynamic sequences were recorded and are shown on a real-time display at 12 frames per second.

This Article

  1. Published online before print July 28, 2005, doi: 10.1073/pnas.0504926102 PNAS August 9, 2005 vol. 102 no. 32 11539-11544
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