Two types of cytotoxic lymphocyte regulation explain kinetics of immune response to human immunodeficiency virus

Rouzine et al. 10.1073/pnas.0510016103.

Supporting Information

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Supporting Figure 7
Supporting Figure 8
Supporting Figure 9

Supporting Figure 7

Fig. 7. Detailed kinetics of separate cell compartments in acute SIV infection (a, c, and e) and potent ART (b, d, and f). Parameter values are the same as in Fig. 6. Groups of cell compartments are infected and permissive cells (a and b) (Fig. 1), helper cells (c and d) (Fig. 4), and CTLs (e and f) (Fig. 3), respectively. Arrows show values defined in Fig. 2b.

Supporting Figure 8

Fig. 8. Fitting virus kinetics of acute infection and drug therapy in a monkey infected with SIVsmE660. Direct effector cells E_D are primary (dashed line in Fig. 5). (a and b) Acute infection. (a) Circles are data points for animal Rh-H352 (1). Solid line, predicted virus load. (b) Separate cell compartments. (c and d) Drug therapy. (c) Circles are data points for animal Rh-H352 (1). Thick line, predicted virus load for 2 weeks of ART, as in experiment (1). Thin and dashed lines, predicted virus load for 30 and 18 days of ART, respectively. (d) Separate cell compartments for 2 weeks of ART. Color legend is shown in a. (a-d) Parameters, as defined in Fig. 5, are as follows: p = 2 10^-5/day per virus unit (vu), R_i = 2.7 ´ 10⁶ vu, d_A = 0.28/day, d_I = 0.66/day, H_i = 1 ´ 10^-5, N_Ni = 2.2 10^-3%, f = 0.21, c = 2.57/day, d = 1.7/day, k = 2.55 per cell per day, r = 0.77/day, V₀ = 25vu, H₀ = 1 ´ 10^-3, a = 3.6 ´ 10^-7/vu per day, d_D = 0.044/day, m = 4.19/day, d_H = 1.7/day, p_R = 5.5 ´ 10^-6/day, s_A = 6.8 ´ 10⁵ vu/day. vu = 1 RNA copy/ml. Fixed parameters are as in the Fig. 5 legend.

J. Virol.71,

Supporting Figure 9

Fig. 9. Simulated depletion of CD8 cells. (a) Short-term depletion in the low-virus state, with the exponential depletion rate 1.4/day, duration 5 days (gray rectangle on top). (b) Transition between the two steady states. Two rounds of depletion for 10 days at the depletion rate of 2/day in the low-viremia and high-viremia state, respectively. Parameter values are the same as in the Fig. 6 legend.