Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations

Zheng et al. 10.1073/pnas.0510426103.

Supporting Information

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Supporting Figure 7
Supporting Text
Supporting Table 2
Supporting Figure 8
Supporting Table 3
Supporting Figure 9
Supporting Table 4





Supporting Figure 7

Fig. 7. ENM and sequence analysis for Thermus aquaticus DNA polymerase’s open/closed transition (2KTQ ® 3KTQ). The mode-dependent robustness (fd'E) computed by the dw-based analysis for the lowest 100 modes. The red curve (with circles) is for the original MSA, and the blue curve (with error bars) represents the average (and standard deviation) of fd'E distribution computed for 100 randomly permuted MSA.





Supporting Figure 8

Fig. 8. ENM and sequence analysis for Dictyostelium myosin (1VOM ® 1MMA). The legend is the same as in Fig. 7.





Supporting Figure 9

Fig. 9. ENM and sequence analysis for E. coli. GroEL (1AON_A ® 1GRL). See the legend of Fig. 7 for description.

This Article

  1. Published online before print May 8, 2006, doi: 10.1073/pnas.0510426103 PNAS May 16, 2006 vol. 103 no. 20 7664-7669
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