Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms

Ting et al. 10.1073/pnas.0608807104.

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Fig. 5. Amyloid precursor protein (APP) overexpression reduces miniature excitatory postsynaptic current (mEPSC) size. A cumulative probability distribution plot of mEPSC size for neurons overexpressing APP (n = 20) compared with control neurons (n = 25) is shown. Values for uninfected and GFP-expressing neurons were indistinguishable, and thus they were pooled as controls. The data points for each group were fit by the method of locally weighted linear regression using a medium LOWESS curve. The distributions are significantly different by the Kolmogorov-Smirnov test, indicating that APP overexpression reduces mEPSC size (D = 0.42, P = 0.03).

This Article

  1. Published online before print December 21, 2006, doi: 10.1073/pnas.0608807104 PNAS January 2, 2007 vol. 104 no. 1 353-358
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