Simultaneous in vivo positron emission tomography and magnetic resonance imaging

Catana et al. 10.1073/pnas.0711622105.

Supporting Information

Files in this Data Supplement:

SI Figure 5
SI Table 1
SI Table 2
SI Figure 6
SI Figure 7




SI Figure 5

Fig. 5. MR-compatible PET scanner. (A) Photograph of the PET insert. (B) Close-up view showing PSAPDs and associated electronics that reside under the high-frequency copper laminate. (C) PET insert in place within the 7-T Bruker BioSpin preclinical MRI system. DAQ, data acquisition; PCB, printed circuit board.





SI Figure 6

Fig. 6. Subtracted MR images in the presence of the powered and unpowered PET insert, demonstrating a featureless noise background. A standard RARE sequence was used.





SI Figure 7

Fig. 7. DWI-EPI. Five different DWIs of a live mouse brain, acquired in the presence of the PET insert.





Table 1. Characteristics of MRI-compatible PET insert

Characteristic

Value

No. of modules

16

Detector ring diameter

60 mm

No. of detector rings

8

No. of crystals/ring

128

Total no. of crystals

1,024

Axial FOV

12 mm

Transaxial FOV

35 mm

Insert length

55 cm

Insert outer diameter

11.8 cm





Table 2. Energy resolution (%) for four scintillator crystals (A) in one of the detector modules acquired while running various MR sequences with the specified parameters (B) and with no sequence running. (Similar results were obtained for all crystals. RARE, rapid acquisition with relaxation enhancement; FLASH, fast low-angle shot.)

A

Sequence

Crystal

#8

#28

#40

#60

None

21.84

21.71

18.38

23.06

RARE

20.92

21.76

19.66

22.88

FLASH

21.43

22.28

18.47

20.55

SE

21.72

21.95

20.55

20.61

B

Parameter

Sequence

RARE

SE

FLASH

Echo time, ms

13.3

16

10

Repetition time, ms

3,000

615

450

RARE factor

8

-

-

Flip angle

-

-

60°

Similar results were obtained for all crystals. RARE, rapid acquisition with relaxation enhancement; FLASH, fast low-angle shot.

This Article

  1. PNAS March 11, 2008 vol. 105 no. 10 3705-3710
  1. OA Abstract
  2. Figures Only
  3. OA Full Text
  4. Full Text (PDF)
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