IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions

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Fig. 5.
Fig. 5.

EndoS pretreatment of pathogenic IgG antibodies inhibits antibody-mediated thrombocytopenia in mice. (A) Female BALB/c mice (n = 3) received i.p. injections of rabbit anti-mouse platelet IgG (αPLT-IgG). Blood samples were taken at regular intervals, and platelet counts were determined by using flow cytometry. (B) Survival plots of BALB/c mice injected with αPLT-IgG that were pretreated with GST-EndoS (n = 4) or GST (n = 4). (C) Platelet counts over time as determined by flow cytometry on blood samples from mice that had received αPLT-IgG pretreated with GST-EndoS.


This Article

  1. Published online before print March 10, 2008, doi: 10.1073/pnas.0711271105 PNAS March 18, 2008 vol. 105 no. 11 4265-4270
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