Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia

Mapping brain change in medication-matched subjects not satisfying criteria for schizophrenia. No temporal lobe deficits are found, suggesting that the progression of the deficits into the temporal lobe is specific to schizophrenia, regardless of medication (and regardless of gender; Fig. 3). Nonetheless, these patients share some symptoms with schizophrenics, exhibiting frontal deficits in a similar anatomical pattern. These frontal deficits (i.e., gray matter loss rates) are statistically significant relative to healthy controls but significantly smaller in magnitude than the greatly accelerated loss rates in schizophrenia.