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Published online on June 28, 2005, 10.1073/pnas.0501539102
PNAS | July 19, 2005 | vol. 102 | no. 29 | 10363-10368


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From The Cover
PHYSIOLOGY
Complex-periodic spiral waves in confluent cardiac cell cultures induced by localized inhomogeneities

Seong-min Hwang, Tae Yun Kim, and Kyoung J. Lee *

National Creative Research Initiative Center for Neuro-dynamics and Department of Physics, Korea University, Seoul 136-713, Korea

Edited by Harry L. Swinney, University of Texas, Austin, TX and approved May 23, 2005 (received for review February 24, 2005)

Spatiotemporal wave activities in excitable heart tissues have long been the subject of numerous studies because they underlie different forms of cardiac arrhythmias. In particular, understanding the dynamics and the instabilities of spiral waves have become very important because they can cause reentrant tachycardia and their subsequent transitions to fibrillation. Although many aspects of cardiac spiral waves have been investigated through experiments and model simulations, their complex properties are far from well understood. Here, we show that intriguing complex-periodic (such as period-2, period-3, period-4, or aperiodic) spiral wave states can arise in monolayer tissues of cardiac cell culture in vitro, and demonstrate that these different dynamic states can coexist with abrupt and spontaneous transitions among them without any change in system parameters; in other words, the medium supports multistability. Based on extensive image data analysis, we have confirmed that these spiral waves are driven by their tips tracing complex orbits whose unusual, meandering shapes are formed by delicate interplay between localized conduction blocks and nonlinear properties of the culture medium.

arrhythmia | cardiac spiral waves | complex oscillations

Author contributions: S.-m.H. and K.J.L. designed research; S.-m.H. and T.Y.K. performed research; S.-m.H. contributed new reagents/analytic tools; S.-m.H., T.Y.K., and K.J.L. analyzed data; and S.-m.H. and K.J.L. wrote the paper.

This paper was submitted directly (Track II) to the PNAS office.

Abbreviations: IBI, interbeat interval; P-n, period-n.

* To whom correspondence should be addressed. E-mail: kyoung{at}nld.korea.ac.kr.

© 2005 by The National Academy of Sciences of the USA


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