Academies Internship Information Sign up for PNAS Online eTocs
Link: Info for AuthorsLink: Editorial BoardLink: AboutLink: SubscribeLink: AdvertiseLink: ContactLink: Sitemap Link: PNAS Home
Proceedings of the National Academy of Sciences
Link: Current Issue "" Link: Archives "" Link: Online Submission ""  Link: Advanced Search



This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kubes, P.
Right arrow Articles by Granger, D. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kubes, P.
Right arrow Articles by Granger, D. N.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg  
What's this?

 Previous Article  | Table of Contents |  Next Article 

Proceedings of the National Academy of Sciences, Vol 88, 4651-4655, Copyright © 1991 by National Academy of Sciences

ARTICLE

Nitric Oxide: An Endogenous Modulator of Leukocyte Adhesion

P Kubes, M Suzuki and DN Granger

The objective of this study was to determine whether endogenous nitric oxide (NO) inhibits leukocyte adhesion to vascular endothelium. This was accomplished by superfusing a cat mesenteric preparation with inhibitors of NO production, NG-monomethyl-L-arginine (L-NMMA) or NG-nitro-L-arginine methyl ester (L-NAME), and observing single (30-µ m diameter) venules by intravital video microscopy. Thirty minutes into the superfusion period the number of adherent and emigrated leukocytes, the erythrocyte velocity, and the venular diameter were measured; venular blood flow and shear rate were calculated from the measured parameters. The contribution of the leukocyte adhesion glycoprotein CD11/CD18 was determined using the CD18-specific monoclonal antibody IB4. Both inhibitors of NO production increased leukocyte adherence more than 15-fold. Leukocyte emigration was also enhanced, whereas venular shear rate was reduced by nearly half. Antibody IB4 abolished the leukocyte adhesion induced by L-NMMA and L-NAME. Incubation of isolated cat neutrophils with L-NMMA, but not L-NAME, resulted in direct upregulation of CD11/CD18 as assessed by flow cytometry. Decrements in venular shear rate induced by partial occlusion of the superior mesenteric artery in untreated animals revealed that only a minor component of L-NAME-induced leukocyte adhesion was shear rate-dependent. The L-NAME-induced adhesion was inhibited by L-arginine but not D-arginine. These data suggest that endothelium-derived NO may be an important endogenous modulator of leukocyte adherence and that impairment of NO production results in a pattern of leukocyte adhesion and emigration that is characteristic of acute inflammation.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg    What's this?


This article has been cited by other articles in HighWire Press-hosted journals:


Home page
 Am. J. Physiol. Cell Physiol.Home page
P. Zania, M. Papaconstantinou, C. S. Flordellis, M. E. Maragoudakis, and N. E. Tsopanoglou
Thrombin mediates mitogenesis and survival of human endothelial cells through distinct mechanisms
Am J Physiol Cell Physiol, May 1, 2008; 294(5): C1215 - C1226.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Talmor, E. Golan, S. Benchetrit, J. Bernheim, O. Klein, J. Green, and G. Rashid
Calcitriol blunts the deleterious impact of advanced glycation end products on endothelial cells
Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1059 - F1064.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. R. Thom, V. M. Bhopale, D. J. Mancini, and T. N. Milovanova
Actin S-Nitrosylation Inhibits Neutrophil {beta}2 Integrin Function
J. Biol. Chem., April 18, 2008; 283(16): 10822 - 10834.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. R. La Bonte, G. Davis-Gorman, G. L. Stahl, and P. F. McDonagh
Complement inhibition reduces injury in the type 2 diabetic heart following ischemia and reperfusion
Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1282 - H1290.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
E. Mata-Greenwood and D.-B. Chen
Racial Differences in Nitric Oxide--Dependent Vasorelaxation
Reproductive Sciences, January 1, 2008; 15(1): 9 - 25.
[Abstract] [PDF]

Home page
 Card Surg AdultHome page
R. Pretre and M. I. Turina
Deep Hypothermic Circulatory Arrest
Card. Surg. Adult, January 1, 2008; 3(2008): 431 - 442.
[Full Text]

Home page
 Cardiovasc ResHome page
V. W.T. Liu and P. L. Huang
Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice
Cardiovasc Res, January 1, 2008; 77(1): 19 - 29.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. L. A. C. Mestriner, F. Spiller, H. J. Laure, F. O. Souto, B. M. Tavares-Murta, J. C. Rosa, A. Basile-Filho, S. H. Ferreira, L. J. Greene, and F. Q. Cunha
Acute-phase protein {alpha}-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism
PNAS, December 4, 2007; 104(49): 19595 - 19600.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Tailor, K. C. Wood, J. L. Wallace, R. D. Specian, and D. N. Granger
Roles of platelet and endothelial cell COX-1 in hypercholesterolemia-induced microvascular dysfunction
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3636 - H3642.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. Won, S.-N. Zhu, M. Chen, A.-M. Teichert, J. E. Fish, C. C. Matouk, M. Bonert, M. Ojha, P. A. Marsden, and M. I. Cybulsky
Relative Reduction of Endothelial Nitric-Oxide Synthase Expression and Transcription in Atherosclerosis-Prone Regions of the Mouse Aorta and in an in Vitro Model of Disturbed Flow
Am. J. Pathol., November 1, 2007; 171(5): 1691 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
L. G. Spagnoli, E. Bonanno, G. Sangiorgi, and A. Mauriello
Role of Inflammation in Atherosclerosis
J. Nucl. Med., November 1, 2007; 48(11): 1800 - 1815.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
G. Letts and J. Loscalzo
Frontiers in Nephrology: Targeting Inflammation Using Novel Nitric Oxide Donors
J. Am. Soc. Nephrol., November 1, 2007; 18(11): 2863 - 2869.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. R. Burns, Z. Zheng, S. H. Soubra, J. Chen, and R. E. Rumbaut
Transendothelial flow inhibits neutrophil transmigration through a nitric oxide-dependent mechanism: potential role for cleft shear stress
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2904 - H2910.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. K. Upmacis, M. J. Crabtree, R. S. Deeb, H. Shen, P. B. Lane, L. E. S. Benguigui, N. Maeda, D. P. Hajjar, and S. S. Gross
Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2878 - H2887.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Y. Li and H. E. Schellhorn
New Developments and Novel Therapeutic Perspectives for Vitamin C
J. Nutr., October 1, 2007; 137(10): 2171 - 2184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G.-X. Zhang, Y. Nagai, T. Nakagawa, H. Miyanaka, Y. Fujisawa, A. Nishiyama, K. Izuishi, K. Ohmori, and S. Kimura
Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2403 - H2408.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Shibata, K. Nagata, and Y. Kobayashi
Cutting Edge: A Critical Role of Nitrogen Oxide in Preventing Inflammation upon Apoptotic Cell Clearance
J. Immunol., September 15, 2007; 179(6): 3407 - 3411.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. L. Goodwin, L. C. Pendleton, M. M. Levy, L. P. Solomonson, and D. C. Eichler
Tumor necrosis factor-{alpha} reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells
Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1115 - H1121.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. J. Lowenstein
Nitric oxide regulation of protein trafficking in the cardiovascular system
Cardiovasc Res, July 15, 2007; 75(2): 240 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
G. Peluffo and R. Radi
Biochemistry of protein tyrosine nitration in cardiovascular pathology
Cardiovasc Res, July 15, 2007; 75(2): 291 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. M. Gazoni, C. G. Tribble, M. Q. Zhao, E. B. Unger, R. A. Farrar, P. I. Ellman, L. G. Fernandez, V. E. Laubach, and I. L. Kron
Pulmonary Macrophage Inhibition and Inhaled Nitric Oxide Attenuate Lung Ischemia-Reperfusion Injury
Ann. Thorac. Surg., July 1, 2007; 84(1): 247 - 253.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Horowitz, D. G. Binion, V. M. Nelson, Y. Kanaa, P. Javadi, Z. Lazarova, C. Andrekopoulos, B. Kalyanaraman, M. F. Otterson, and P. Rafiee
Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease
Am J Physiol Gastrointest Liver Physiol, May 1, 2007; 292(5): G1323 - G1336.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. Favre, P. Musette, V. Douin-Echinard, K. Laude, J.-P. Henry, J.-F. Arnal, C. Thuillez, and V. Richard
Toll-Like Receptors 2-Deficient Mice Are Protected Against Postischemic Coronary Endothelial Dysfunction
Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 1064 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
N. K J Adhikari, K. E A Burns, J. O Friedrich, J. T Granton, D. J Cook, and M. O Meade
Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis
BMJ, April 14, 2007; 334(7597): 779 - 779.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. T. Blikslager, A. J. Moeser, J. L. Gookin, S. L. Jones, and J. Odle
Restoration of Barrier Function in Injured Intestinal Mucosa
Physiol Rev, April 1, 2007; 87(2): 545 - 564.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Laragione, N. C. Yarlett, M. Brenner, A. Mello, B. Sherry, E. J. Miller, C. N. Metz, and P. S. Gulko
The Arthritis Severity Quantitative Trait Loci Cia4 and Cia6 Regulate Neutrophil Migration into Inflammatory Sites and Levels of TNF-{alpha} and Nitric Oxide
J. Immunol., February 15, 2007; 178(4): 2344 - 2351.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. Nagaoka, E. Sato, A. Takahashi, S. Yokohama, and A. Yoshida
Retinal Circulatory Changes Associated with Interferon-Induced Retinopathy in Patients with Hepatitis C
Invest. Ophthalmol. Vis. Sci., January 1, 2007; 48(1): 368 - 375.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
C. D. Mazer, F. Briet, K. R. Blight, D. J. Stewart, M. Robb, Z. Wang, A. M. Harrington, W. Mak, X. Li, and G. M.T. Hare
Increased cerebral and renal endothelial nitric oxide synthase gene expression after cardiopulmonary bypass in the rat
J. Thorac. Cardiovasc. Surg., January 1, 2007; 133(1): 13 - 20.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. E. Moon
Nitroglycerine: relief from the heartache of decompression sickness?
J Appl Physiol, December 1, 2006; 101(6): 1537 - 1538.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
U. Skaleric, B. Gaspirc, N. McCartney-Francis, A. Masera, and S. M. Wahl
Proinflammatory and Antimicrobial Nitric Oxide in Gingival Fluid of Diabetic Patients with Periodontal Disease
Infect. Immun., December 1, 2006; 74(12): 7010 - 7013.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. R. Duranski, J. W. Elrod, J. W. Calvert, N. S. Bryan, M. Feelisch, and D. J. Lefer
Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2980 - H2986.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. D. Searles
Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression
Am J Physiol Cell Physiol, November 1, 2006; 291(5): C803 - C816.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. Shibata, K. Nagata, and Y. Kobayashi
A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells
J. Leukoc. Biol., October 1, 2006; 80(4): 744 - 752.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
G. Folco and R. C. Murphy
Eicosanoid Transcellular Biosynthesis: From Cell-Cell Interactions to in Vivo Tissue Responses
Pharmacol. Rev., September 1, 2006; 58(3): 375 - 388.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
O. A HATOUM, J. HEIDEMANN, and D. G BINION
The intestinal microvasculature as a therapeutic target in inflammatory bowel disease.
Ann. N.Y. Acad. Sci., August 1, 2006; 1072: 78 - 97.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Garthwaite, K. Bartus, D. Malcolm, D. Goodwin, M. Kollb-Sielecka, C. Dooldeniya, and J. Garthwaite
Signaling from blood vessels to CNS axons through nitric oxide.
J. Neurosci., July 19, 2006; 26(29): 7730 - 7740.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. J. Lowenstein
Beneficial effects of neuronal nitric oxide synthase in atherosclerosis.
Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1417 - 1418.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. W. Elrod, J. J.M. Greer, N. S. Bryan, W. Langston, J. F. Szot, H. Gebregzlabher, S. Janssens, M. Feelisch, and D. J. Lefer
Cardiomyocyte-Specific Overexpression of NO Synthase-3 Protects Against Myocardial Ischemia-Reperfusion Injury
Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1517 - 1523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Hataishi, A. C. Rodrigues, T. G. Neilan, J. G. Morgan, E. Buys, S. Shiva, R. Tambouret, D. S. Jassal, M. J. Raher, E. Furutani, et al.
Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H379 - H384.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
V. Anttila, H. Christou, I. Hagino, Y. Iwata, B. A. Mettler, A. Fernandez-Gonzalez, D. Zurakowski, and R. A. Jonas
Cerebral Endothelial Nitric Oxide Synthase Expression is Reduced After Very Low Flow Bypass
Ann. Thorac. Surg., June 1, 2006; 81(6): 2202 - 2206.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. Bani, L. Giannini, A. Ciampa, E. Masini, Y. Suzuki, M. Menegazzi, S. Nistri, and H. Suzuki
Epigallocatechin-3-Gallate Reduces Allergen-Induced Asthma-Like Reaction in Sensitized Guinea Pigs
J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1002 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Takenaka, Y. Nishimura, T. Nishiuma, A. Sakashita, T. Yamashita, K. Kobayashi, M. Satouchi, T. Ishida, S. Kawashima, and M. Yokoyama
Ventilator-induced lung injury is reduced in transgenic mice that overexpress endothelial nitric oxide synthase
Am J Physiol Lung Cell Mol Physiol, June 1, 2006; 290(6): L1078 - L1086.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
A. Nakajima, K. Ueda, M. Takaoka, Y. Yoshimi, and Y. Matsumura
Opposite Effects of Pre- and Postischemic Treatments with Nitric Oxide Donor on Ischemia/Reperfusion-Induced Renal Injury
J. Pharmacol. Exp. Ther., March 1, 2006; 316(3): 1038 - 1046.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. A. Kirkby and C. A. Adin
Products of heme oxygenase and their potential therapeutic applications
Am J Physiol Renal Physiol, March 1, 2006; 290(3): F563 - F571.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
M. Sahin, C. Arslan, M. Naziroglu, S. E. Tunc, M. Demirci, R. Sutcu, and N. Yilmaz
Asymmetric Dimethylarginine and Nitric Oxide Levels as Signs of Endothelial Dysfunction in Behcet's Disease
Ann. Clin. Lab. Sci., January 1, 2006; 36(4): 449 - 454.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. J. McMahon and A. Doctor
Extrapulmonary effects of inhaled nitric oxide: role of reversible s-nitrosylation of erythrocytic hemoglobin.
Proceedings of the ATS, January 1, 2006; 3(2): 153 - 160.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. J.D. Griffiths and T. W. Evans
Inhaled Nitric Oxide Therapy in Adults
N. Engl. J. Med., December 22, 2005; 353(25): 2683 - 2695.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Yamaoka, Y. Yonemitsu, K. Komori, H. Baba, T. Matsumoto, T. Onohara, and Y. Maehara
Ex vivo electroporation as a potent new strategy for nonviral gene transfer into autologous vein grafts
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1865 - H1872.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. S. Scotland, M. Cohen, P. Foster, M. Lovell, A. Mathur, A. Ahluwalia, and A. J. Hobbs
C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression
PNAS, October 4, 2005; 102(40): 14452 - 14457.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
E. Fung, R. R. Fiscus, A. P. C. Yim, G. D. Angelini, and A. A. Arifi
The Potential Use of Type-5 Phosphodiesterase Inhibitors in Coronary Artery Bypass Graft Surgery
Chest, October 1, 2005; 128(4): 3065 - 3073.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. Tsukimori, K. Fukushima, A. Tsushima, and H. Nakano
Generation of Reactive Oxygen Species by Neutrophils and Endothelial Cell Injury in Normal and Preeclamptic Pregnancies
Hypertension, October 1, 2005; 46(4): 696 - 700.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
T. K. Krempl, R. Maas, K. Sydow, T. Meinertz, R. H. Boger, and J. Kahler
Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events
Eur. Heart J., September 2, 2005; 26(18): 1846 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. N. Morrell, K. Matsushita, and C. J. Lowenstein
A Novel Inhibitor of N-Ethylmaleimide-Sensitive Factor Decreases Leukocyte Trafficking and Peritonitis
J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 155 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
A. Bouman, M. J. Heineman, and M. M. Faas
Sex hormones and the immune response in humans
Hum. Reprod. Update, July 1, 2005; 11(4): 411 - 423.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. E. Barbato, B. S. Zuckerbraun, M. Overhaus, K. G. Raman, and E. Tzeng
Nitric oxide modulates vascular inflammation and intimal hyperplasia in insulin resistance and the metabolic syndrome
Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H228 - H236.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Weber, C. H. Hagedorn, D. G. Harrison, and C. D. Searles
Laminar Shear Stress and 3' Polyadenylation of eNOS mRNA
Circ. Res., June 10, 2005; 96(11): 1161 - 1168.
[Abstract] [Full Text] [PDF]