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This Article:
Brydon L. Bennett, Dennis T. Sasaki, Brion W. Murray, Eoin C. O'Leary, Steve T. Sakata, Weiming Xu, Jim C. Leisten, Aparna
Motiwala, Steve Pierce, Yoshitaka Satoh, Shripad S. Bhagwat, Anthony M. Manning, and David W. Anderson
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
PNAS 2001 98: 13681-13686.
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
PNAS 2001 98: 13681-13686.
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Loss of catalase increases malignant mouse keratinocyte cell growth through activation of the stress activated JNK pathway Neale T. Hanke, Joanne S. Finch, and G. Timothy Bowden Molecular Carcinogenesis (2008) 47: 349 Link to Article |
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Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK Gareth M Thomas, Da-Ting Lin, Mutsuo Nuriya, and Richard L Huganir The EMBO Journal (2008) 27: 361 Link to Article |
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c-Jun is a negative regulator of myelination D. B. Parkinson, A. Bhaskaran, P. Arthur-Farraj, L. A. Noon, A. Woodhoo, A. C. Lloyd, M. L. Feltri, L. Wrabetz, A. Behrens, and R. Mirsky The Journal of Cell Biology (2008) 181: 625 Link to Article |
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High-mobility group box 1 protein induces HIV-1 expression from persistently infected cells Sylvain Thierry, Jo??l Gozlan, Amandine Jaulmes, Rachel Boniface, Nadine Nasreddine, Fran??ois Strauss, and Vincent Mar??chal AIDS (2007) 21: 283???292 Link to Article |
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Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells Theodore O. Garnett, Maria Filippova, and Penelope Jayne Duerksen-Hughes APOPTOSIS (2007) 12: 1299 Link to Article |
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Inhibition of c-Jun N-terminal kinase in the CA1 region of the dorsal hippocampus blocks extinction of inhibitory avoidance
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Cardiolipin activates MAP kinases during premature senescence in normal human fibroblasts Palaniyappan Arivazhagan and Dai Ayusawa Biogerontology (2007) 8: 621 Link to Article |
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PTH regulation of c-Jun terminal kinase and p38 MAPK cascades in intestinal cells from young and aged rats Natalia Buzzi, Ricardo Boland, and Ana Russo Boland Biogerontology (2007) 8: 189 Link to Article |
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JNK pathway regulates estradiol-induced apoptosis in hormone-dependent human breast cancer cells Nedret Altiok, Meral Koyuturk, and Soner Altiok Breast Cancer Research and Treatment (2007) 105: 247 Link to Article |
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Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats N Rawal, C Parish, G Castelo-Branco, and E Arenas Cell Death and Differentiation (2007) 14: 381 Link to Article |
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Are MAP Kinases Drug Targets? Yes, but Difficult Ones Simona Margutti and Stefan A. Laufer ChemMedChem (2007) 2: 1116 Link to Article |
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JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the
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Extensive structural remodeling of the injured spinal cord revealed by phosphorylated MAP1B in sprouting axons and degenerating
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Kinase signaling pathways as potential targets in the treatment of Parkinson’s disease Elisa Greggio and Andrew Singleton Expert Review of Proteomics (2007) 4: 783 Link to Article |
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Motile membrane protrusions regulate cell–cell adhesion and migration of olfactory ensheathing glia Louisa C. E. Windus, Christina Claxton, Chelsea L. Allen, Brian Key, and James A. St John Glia (2007) 55: 1708 Link to Article |
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Negative Regulation by p70 S6 Kinase of FGF-2?Stimulated VEGF Release Through Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase in Osteoblasts Shinji Takai, Haruhiko Tokuda, Yoshiteru Hanai, Atsushi Harada, Eisuke Yasuda, Rie Matsushima-Nishiwaki, Hisaaki Kato, Shinji Ogura, Toshiki Ohta, and Osamu Kozawa Journal of Bone and Mineral Research (2007) 22: 337 Link to Article |
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Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts Catherine M Cowan, Xinquan Jiang, Tiffany Hsu, Chia Soo, Beiji Zhang, Joyce Z Wang, Shun’ichi Kuroda, Benjamin Wu, Zhiyuan Zhang, and Xinli Zhang Journal of Bone and Mineral Research (2007) 22: 918 Link to Article |
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Pro-apoptotic activity of oncogenic H-Ras for histone deacetylase inhibitor to induce apoptosis of human cancer HT29 cells Shambhunath Choudhary and Hwa-Chain Robert Wang Journal of Cancer Research and Clinical Oncology (2007) 133: 725 Link to Article |
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(−)-epigallocatechin gallate enhances prostaglandin F2α-induced VEGF synthesis via upregulating SAPK/JNK activation in osteoblasts Haruhiko Tokuda, Shinji Takai, Rie Matsushima-Nishiwaki, Shigeru Akamatsu, Yoshiteru Hanai, Takayuki Hosoi, Atsushi Harada, Toshiki Ohta, and Osamu Kozawa Journal of Cellular Biochemistry (2007) 100: 1146 Link to Article |
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Inhibitory effect of TNF-α on the intestinal absorption of galactose P. Amador, J. García-Herrera, M.C. Marca, J. de la Osada, S. Acín, M.A. Navarro, M.T. Salvador, M.P. Lostao, and M.J. Rodríguez-Yoldi Journal of Cellular Biochemistry (2007) 101: 99 Link to Article |
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Apoptotic signaling in methylglyoxal-treated human osteoblasts involves oxidative stress, c-Jun N-terminal kinase, caspase-3,
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Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway Igor Matushansky, Eva Hernando, Nicholas D. Socci, Joslyn E. Mills, Tulio A. Matos, Mark A. Edgar, Samuel Singer, Robert G. Maki, and Carlos Cordon-Cardo Journal of Clinical Investigation (2007) 117: 3248 Link to Article |
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Stimulation-Specific Contribution of p38 and JNK to IFN-? Gene Expression in Human Macrophages Thornik Reimer, Matthias Schweizer, and Thomas W. Jungi Journal of Interferon & Cytokine Research (2007) 27: 751 Link to Article |
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Helium–Neon Laser Irradiation Stimulates Cell Proliferation through Photostimulatory Effects in Mitochondria Wan-Ping Hu, Jeh-Jeng Wang, Chia-Li Yu, Cheng-Che E Lan, Gow-Shing Chen, and Hsin-Su Yu Journal of Investigative Dermatology (2007) 127: 2048 Link to Article |
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Intestinal d-Galactose Transport in an Endotoxemia Model in the Rabbit P. Amador, J. García-Herrera, M. C. Marca, J. la Osada, S. Acín, M. A. Navarro, M. T. Salvador, M. P. Lostao, and M. J. Rodríguez-Yoldi Journal of Membrane Biology (2007) 215: 125 Link to Article |
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The differential effects of single or repeated restraint stress on kainic acid-induced neuronal death in the hippocampal CA3
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Oxidative stress-induced c-Jun N-terminal kinase (JNK) activation in tendon cells upregulates MMP1 mRNA and protein expression Fang Wang, George A.C. Murrell, and Min-Xia Wang Journal of Orthopaedic Research (2007) 25: 378 Link to Article |
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Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family–mediated transcriptional activation of
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Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian
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Stable expression of intracellular Notch suppresses v-Src-induced transformation in avian neural cells S Mateos, S Amarir, D Laugier, M Marx, and G Calothy Oncogene (2007) 26: 3338 Link to Article |
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Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway N V Oleinik, N I Krupenko, and S A Krupenko Oncogene (2007) 26: 7222 Link to Article |
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Suppression of Alloreactivity and Allograft Rejection by SP600125, a Small Molecule Inhibitor of c-Jun N-terminal Kinase Akihiro Tabata, Masayuki Morikawa, Masahiro Miyajima, Brydon L. Bennett, Yoshitaka Satoh, Jianhua Huang, Yasuaki Tamura, Noriyuki Sato, and Tomio Abe Transplantation (2007) 83: 1358 Link to Article |
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C-Jun N-Terminal Kinase (JNK) Regulation of iNOS Expression in Glial Cells: Predominant Role of JNK1 Isoform Siddharama Pawate and Narayan R. Bhat Antioxidants and Redox Signaling (2006) 8: 903 Link to Article |
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Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to
differentiation-inducing or microtubule-disrupting agents Julie A. Vrana, Emily S. Cleaveland, Alan Eastman, and Ruth W. Craig APOPTOSIS (2006) 11: 1275 Link to Article |
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Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor Géraldine Ibarz, Catherine Oiry, Eric Carnazzi, Philippe Crespy, Chantal Escrieut, Daniel Fourmy, Jean Claude Galleyrand, Didier Gagne, and Jean Martinez British Journal of Pharmacology (2006) 147: 951 Link to Article |
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Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis S Inoue, D Twiddy, M J S Dyer, and G M Cohen Cell Death and Differentiation (2006) 13: 2160 Link to Article |
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Inhibition of mitogen-activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin-8
mRNA Sarah Batty, Edith M. C. Chow, Altaf Kassam, Sandy D. Der, and Jeremy Mogridge Cellular Microbiology (2006) 8: 130 Link to Article |
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G-CSF-mediated inhibition of JNK is a key mechanism for Lactobacillus rhamnosus-induced suppression of TNF production in macrophages Sung O. Kim, Haroon I. Sheikh, Soon-Duck Ha, Andrew Martins, and Gregor Reid Cellular Microbiology (2006) 8: 1958 Link to Article |
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Activation of c-Jun N-terminal kinase (JNK) signalling in experimentally induced gastric lesions in rats K. Mitsuyama, O. Tsuruta, Y. Matsui, K. Harada, N. Tomiyasu, A. Suzuki, K. Takaki, J. Masuda, K. Handa, and Y. Satoh Clinical & Experimental Immunology (2006) 143: 24 Link to Article |
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Thermal injury-induced peroxynitrite production and pulmonary inducible nitric oxide synthase expression depend on JNK/AP-1
signaling Lee-Wei Chen, Wei-Jung Chang, Jyh-Seng Wang, and Ching-Mei Hsu Critical Care Medicine (2006) 34: 142 Link to Article |
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ERK1/2 but not p38 MAP kinase is essential for the long-term depression in mouse cerebellar slices Aya Ito-Ishida, Wataru Kakegawa, and Michisuke Yuzaki European Journal of Neuroscience (2006) 24: 1617 Link to Article |
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Update on COX-2 inhibitor patents with a focus on optimised formulation and therapeutic scope of drug combinations making
use of COX-2 inhibitors Ulrike Puhlmann, Dirk Schafer, and Christina Ziemann Expert Opinion on Therapeutic Patents (2006) 16: 403 Link to Article |
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Growth suppression of human mast cells expressing constitutively active c-kit receptors by JNK inhibitor SP600125 Bin Wang, Junichi Tsukada, Takehiro Higashi, Takamitsu Mizobe, Ai Matsuura, Fumihiko Mouri, Norifumi Sawamukai, Chisei Ra, and Yoshiya Tanaka Genes to Cells (2006) 11: 983 Link to Article |
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TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: Differential signaling
mechanisms of TLR3-induced IP-10 and IL-8 gene expression Chanhee Park, Soojin Lee, Ik-Hyun Cho, Hyun Kyoung Lee, Donghoon Kim, Se-Young Choi, Seog Bae Oh, Kyungpyo Park, Joong Soo Kim, and Sung Joong Lee Glia (2006) 53: 248 Link to Article |
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Extracellular ATP counteracts the ERK1/2-mediated death-promoting signaling cascades in astrocytes Youichi Shinozaki, Schuichi Koizumi, Yasuo Ohno, Taku Nagao, and Kazuhide Inoue Glia (2006) 54: 606 Link to Article |
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Glial cell line-derived neurotrophic factor promotes olfactory ensheathing cells migration Li Cao, Zhida Su, Qiang Zhou, Baolai Lv, Xiujie Liu, Li Jiao, Zhihua Li, Yanling Zhu, Zhihui Huang, and Aijun Huang Glia (2006) 54: 536 Link to Article |
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Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury Laura Llacuna, Montserrat Marí, Carmen Garcia-Ruiz, José C. Fernandez-Checa, and Albert Morales Hepatology (2006) 44: 561 Link to Article |
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The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute
murine colitis Kiran Assi, Rex Pillai, Antonio Gomez-Munoz, David Owen, and Baljinder Salh Immunology (2006) 118: 112 Link to Article |
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Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-α in human tracheal smooth muscle cells: Involvement
of MAPKs, NF-κB, p300, and histone acetylation Chiang-Wen Lee, Wei-Ning Lin, Chih-Chung Lin, Shue-Fen Luo, Jong-Shyan Wang, Jacques Pouyssegur, and Chuen-Mao Yang Journal of Cellular Physiology (2006) 207: 174 Link to Article |
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Signaling pathways of LIGHT induced macrophage migration and vascular smooth muscle cell proliferation Chun-Yu Wei, Yin-Hsiang Chou, Feng-Ming Ho, Shie-Liang Hsieh, and Wan-Wan Lin Journal of Cellular Physiology (2006) 209: 735 Link to Article |
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Long term metabolic arrest and recovery of HEK293 spheroids involves NF-κB signaling and sustained JNK activation Graham D. Jack, E. Andrew Mead, James F. Garst, M. Carla Cabrera, Andrea M. DeSantis, Stephen M. Slaughter, Jody Jervis, Andrew I. Brooks, Malcolm Potts, and Richard F. Helm Journal of Cellular Physiology (2006) 206: 526 Link to Article |
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C-Jun N-terminal kinase inhibition and α-tocopherol protect midbrain dopaminergic neurons from interferon-γ/lipopolysaccharide-induced
injury without affecting nitric oxide production Haruki Shibata, Hiroshi Katsuki, Mitsugi Okawara, Toshiaki Kume, and Akinori Akaike Journal of Neuroscience Research (2006) 83: 102 Link to Article |
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Map kinase c-Jun N-terminal kinase mediates PMMA induction of osteoclasts Y. Yamanaka, Y. Abu-Amer, R. Faccio, and J.C. Clohisy Journal of Orthopaedic Research (2006) 24: 1349 Link to Article |
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Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38
mapk in human diploid lung fibroblasts Hong Ju Du, Ning Tang, Bing Ci Liu, Bao Rong You, Fu Hai Shen, Meng Ye, Ai Gao, and Chuan Shu Huang Molecular and Cellular Biochemistry (2006) 287: 79 Link to Article |
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