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down Maria A. Rupnick, Dipak Panigrahy, Chen-Yu Zhang, Susan M. Dallabrida, Bradford B. Lowell, Robert Langer, and M. Judah Folkman
From the Cover: Adipose tissue mass can be regulated through the vasculature
PNAS 99: 10730-10735; published online as 10.1073/pnas.162349799

Abstract 1 of 1backFrom the Cover
Medical Sciences
Adipose tissue mass can be regulated through the vasculature

Maria A. Rupnick *, {dagger}, {ddagger} §, Dipak Panigrahy {dagger}, Chen-Yu Zhang ¶, Susan M. Dallabrida {dagger}, Bradford B. Lowell ¶, Robert Langer {ddagger}, and M. Judah Folkman {dagger}

*Division of Cardiovascular Medicine, Brigham and Women's Hospital, {dagger}Division of Surgical Research, Children's Hospital, and Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02115; and{ddagger} Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

Contributed by M. Judah Folkman and approved June 11, 2002

Tumor growth is angiogenesis dependent. We hypothesized that nonneoplastictissue growth also depends on neovascularization. We chose adiposetissue as an experimental system because of its remodeling capacity.Mice from different obesity models received anti-angiogenicagents. Treatment resulted in dose-dependent, reversible weightreduction and adipose tissue loss. Marked vascular remodelingwas evident in adipose tissue sections, which revealed decreasedendothelial proliferation and increased apoptosis in treatedmice compared with controls. Continuous treatment maintained micenear normal body weights for age without adverse effects. Metabolicadaptations in food intake, metabolic rate, and energy substrateutilization were associated with anti-angiogenic weight loss. Weconclude that adipose tissue mass is sensitive to angiogenesis inhibitorsand can be regulated by its vasculature.

Abbreviations: vWF, von Willebrand factor

§rupnick{at}hub.tch.harvard.edu

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