Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein

Sundin et al. 10.1073/pnas.0501451102.

Supporting Information

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Supporting Text
Supporting Figure 7
Supporting Figure 8

Supporting Figure 7

Fig. 7. Coding Exons of MFRP. Diagram showing genomic interval of MFRP, with noncoding mRNA sequence indicated by black rectangles and coding sequence by solid blue rectangles. N terminal is on the left. Extent of exon amplimers is indicated by open blue rectangles, with forward primers on the left and reverse on the right.

Supporting Figure 8

Fig. 8. Simplified rendering of x-ray structure of C1s backbone. This is an x-ray structure obtained from the National Institutes of Health /National Center for Biotechnology Information web site (www.ncbi.nlm.nih.gov/ Protein Data Bank ID code 1NZI). Ile-182 is highlighted in yellow.