Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

  1. John V. Raelson*,†,
  2. Randall D. Little*,
  3. Andreas Ruether‡,
  4. Hélène Fournier*,
  5. Bruno Paquin*,
  6. Paul Van Eerdewegh*,
  7. W. E. C. Bradley§,
  8. Pascal Croteau*,
  9. Quynh Nguyen-Huu*,
  10. Jonathan Segal*,
  11. Sophie Debrus*,
  12. René Allard*,
  13. Philip Rosenstiel‡,
  14. Andre Franke‡,
  15. Gunnar Jacobs‡,
  16. Susanna Nikolaus,
  17. Jean-Michel Vidal*,
  18. Peter Szego‖,
  19. Nathalie Laplante*,
  20. Hilary F. Clark**,
  21. René J. Paulussen*,
  22. John W. Hooper*,
  23. Tim P. Keith*,
  24. Abdelmajid Belouchi*, and
  25. Stefan Schreiber‡,
  1. *Genizon BioSciences, Inc., St. Laurent, QC, Canada H4T 2C7;
  2. ‡Institute for Clinical Molecular Biology and
  3. Department of General Internal Medicine, Christian-Albrechts-University Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany;
  4. §Centre de Recherche du CHUM, Notre-Dame Hospital, Department of Medicine, University of Montreal, Montreal, QC, Canada H2L 4M1;
  5. ‖Therapeutic Gastroenterology, McGill University, Montreal, QC, Canada H3A 1A1; and
  6. **Department of Bioinformatics, Genentech, Inc., South San Francisco, CA 94080

  1. Communicated by Raymond L. White, University of California, San Francisco, Emeryville, CA, July 25, 2007 (received for review April 9, 2007)

  1. Fig. 1.
    View larger version:
    Fig. 1.

    Overview of GWA study, fine-mapping, and replication studies in regions on chromosomes 1p31.3, 4p16.1, and 3p21.31. A shows the results of the GWA analysis for three regions (1p31.3, 700 kb; 4p16.1, 600 kb; and 3p21.31, 1.2 Mb). Plots indicate the nominal −log10 P values for haplotypes corresponding to five (green), seven (red), and nine (orange) consecutive marker windows. B shows the FM results for the QFP, C shows the FM results for the German trios, and D shows the FM results for the German cases/controls. Regions sequenced in the 1p31.3 and 4p16.1 regions are shown as a blue bar. E shows the LD structure in controls from the QFP based on the D′ algorithm as implemented in Haploview 3.32 (36).


Footnotes

  • †To whom correspondence should be addressed. E-mail: john.raelson{at}genizon.com
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  1. Published online before print September 5, 2007, doi: 10.1073/pnas.0706645104 PNAS September 11, 2007 vol. 104 no. 37 14747-14752
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