Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression

Yanai et al. 10.1073/pnas.0611559104.

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SI Figure 6




SI Figure 6

Fig. 6. (a) Expression of IFN-a and IFN-b in IRF5-/- MEFs. WT and IRF5-deficient MEFs were infected with 7.5 HA units (HAU) of Newcastle disease virus (NDV) for the indicated periods. Tatal RNA was prepared and subjected to RNA blot analysis. RNA blot analysis was performed as described previously (1). (b) Nuclear localization of IRF5 upon virus infection. YFP-IRF5 expression vectors was as described previously (2). MEFs were transfected with YFP-IRF5 expression vector. After 12 h, MEFs were infected with 7.5 HAU of NDV (Right) or untreated (Left). Nuclear localization of IRF5 was obserbed after 12 h of infection.

1. Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, Nakaya T, Katsuki M, Noguchi S, Tanaka N, Taniguchi T (2000) Immunity 13:539-548.

2. Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak T W, Taniguchi T (2005) Nature 434:243-249.

This Article

  1. Published online before print February 20, 2007, doi: 10.1073/pnas.0611559104 PNAS February 27, 2007 vol. 104 no. 9 3402-3407
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