Table of Contents

April 15, 2008; 105 (15)

FROM THE COVER

This Week in PNAS

This Week in PNAS:
In This Issue
PNAS 2008 105:5651-5652; doi:10.1073/iti1508105

Commentaries

Commentary:
- John H. Wilson
Knockout punches with a fistful of zinc fingers
PNAS 2008 105:5653-5654; published ahead of print April 9, 2008, doi:10.1073/pnas.0802298105
- See companion article on page 5809 in issue 15 of volume 105
Commentary:
- Christopher T. Walsh
- and Elizabeth M. Nolan
Morphing peptide backbones into heterocycles
PNAS 2008 105:5655-5656; published ahead of print April 8, 2008, doi:10.1073/pnas.0802300105
- See companion article on page 5879 in issue 15 of volume 105

Physical Sciences

Chemistry

Select this article
Physical Sciences - Chemistry - Biological Sciences - Biochemistry:
- Youngmi Kim,
- Zehui Cao,
- and Weihong Tan
Molecular assembly for high-performance bivalent nucleic acid inhibitor
PNAS 2008 105:5664-5669; published ahead of print April 8, 2008, doi:10.1073/pnas.0711803105
Select this article
Physical Sciences - Chemistry - Biological Sciences - Biochemistry:
- Ping Lin,
- Vinod K. Batra,
- Lars C. Pedersen,
- William A. Beard,
- Samuel H. Wilson,
- and Lee G. Pedersen
Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β
PNAS 2008 105:5670-5674; published ahead of print April 7, 2008, doi:10.1073/pnas.0801257105

Physics

Select this article
Physical Sciences - Physics:
- S. Condamin,
- V. Tejedor,
- R. Voituriez,
- O. Bénichou,
- and J. Klafter
Probing microscopic origins of confined subdiffusion by first-passage observables
PNAS 2008 105:5675-5680; published ahead of print April 7, 2008, doi:10.1073/pnas.0712158105

Social Sciences

Select this article
Social Sciences - Social Sciences:
- Douglas Almond
- and Lena Edlund
Son-biased sex ratios in the 2000 United States Census
PNAS 2008 105:5681-5682; published ahead of print March 31, 2008, doi:10.1073/pnas.0800703105

Biological Sciences

Biophysics

Select this article
Biological Sciences - Biophysics:
- Johannes Wiedersich,
- Simone Köhler,
- Arne Skerra,
- and Josef Friedrich
Temperature and pressure dependence of protein stability: The engineered fluorescein-binding lipocalin FluA shows an elliptic phase diagram
PNAS 2008 105:5756-5761; published ahead of print April 7, 2008, doi:10.1073/pnas.0710409105
Select this article
Biological Sciences - Biophysics:
- Mark Wells,
- Henning Tidow,
- Trevor J. Rutherford,
- Phineus Markwick,
- Malene Ringkjobing Jensen,
- Efstratios Mylonas,
- Dmitri I. Svergun,
- Martin Blackledge,
- and Alan R. Fersht
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain
PNAS 2008 105:5762-5767; published ahead of print April 7, 2008, doi:10.1073/pnas.0801353105

Cell Biology

Select this article
Biological Sciences - Cell Biology:
- David W. Killilea
- and Bruce N. Ames
From the Cover: Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts
PNAS 2008 105:5768-5773; published ahead of print April 7, 2008, doi:10.1073/pnas.0712401105
Select this article
Biological Sciences - Cell Biology:
- Kathryn B. Horwitz,
- Wendy W. Dye,
- Joshua Chuck Harrell,
- Peter Kabos,
- and Carol A. Sartorius
Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts
PNAS 2008 105:5774-5779; published ahead of print April 7, 2008, doi:10.1073/pnas.0706216105

Developmental Biology

Select this article
Biological Sciences - Developmental Biology:
- Takako Kondo,
- Patrick L. Sheets,
- David A. Zopf,
- Heather L. Aloor,
- Theodore R. Cummins,
- Rebecca J. Chan,
- and Eri Hashino
Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells
PNAS 2008 105:5780-5785; published ahead of print April 7, 2008, doi:10.1073/pnas.0708704105

Evolution

Select this article
Biological Sciences - Evolution:
- Alexander G. S. C. Liu,
- Erik R. Seiffert,
- and Elwyn L. Simons
Stable isotope evidence for an amphibious phase in early proboscidean evolution
PNAS 2008 105:5786-5791; published ahead of print April 14, 2008, doi:10.1073/pnas.0800884105
Select this article
Biological Sciences - Evolution:
- Bernard C. Lamb,
- Snehal Mandaokar,
- Basma Bahsoun,
- Isabella Grishkan,
- and Eviatar Nevo
Differences in spontaneous mutation frequencies as a function of environmental stress in soil fungi at “Evolution Canyon,” Israel
PNAS 2008 105:5792-5796; published ahead of print April 9, 2008, doi:10.1073/pnas.0801995105
Select this article
Biological Sciences - Evolution:
- Chaolin Zhang,
- Wen-Hsiung Li,
- Adrian R. Krainer,
- and Michael Q. Zhang
RNA landscape of evolution for optimal exon and intron discrimination
PNAS 2008 105:5797-5802; published ahead of print April 7, 2008, doi:10.1073/pnas.0801692105
Select this article
Biological Sciences - Evolution:
- Luis David Alcaraz,
- Gabriela Olmedo,
- Germán Bonilla,
- René Cerritos,
- Gustavo Hernández,
- Alfredo Cruz,
- Enrique Ramírez,
- Catherine Putonti,
- Beatriz Jiménez,
- Eva Martínez,
- Varinia López,
- Jacqueline L. Arvizu,
- Francisco Ayala,
- Francisco Razo,
- Juan Caballero,
- Janet Siefert,
- Luis Eguiarte,
- Jean-Philippe Vielle,
- Octavio Martínez,
- Valeria Souza,
- Alfredo Herrera-Estrella,
- and Luis Herrera-Estrella
The genome of Bacillus coahuilensis reveals adaptations essential for survival in the relic of an ancient marine environment
PNAS 2008 105:5803-5808; published ahead of print April 11, 2008, doi:10.1073/pnas.0800981105

Genetics

Select this article
Biological Sciences - Genetics:
- Yolanda Santiago,
- Edmond Chan,
- Pei-Qi Liu,
- Salvatore Orlando,
- Lin Zhang,
- Fyodor D. Urnov,
- Michael C. Holmes,
- Dmitry Guschin,
- Adam Waite,
- Jeffrey C. Miller,
- Edward J. Rebar,
- Philip D. Gregory,
- Aaron Klug,
- and Trevor N. Collingwood
From the Cover: Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases
PNAS 2008 105:5809-5814; published ahead of print March 21, 2008, doi:10.1073/pnas.0800940105
Open Access Article
- See commentary article on page 5653 in issue 15 of volume 105
Select this article
Biological Sciences - Genetics:
- Gaganpreet K. Sidhu,
- Sachin Rustgi,
- Mustafa N. Shafqat,
- Diter von Wettstein,
- and Kulvinder S. Gill
Fine structure mapping of a gene-rich region of wheat carrying Ph1 , a suppressor of crossing over between homoeologous chromosomes
PNAS 2008 105:5815-5820; published ahead of print April 8, 2008, doi:10.1073/pnas.0800931105
Select this article
Biological Sciences - Genetics:
- Laurence Decourty,
- Cosmin Saveanu,
- Kenza Zemam,
- Florence Hantraye,
- Emmanuel Frachon,
- Jean-Claude Rousselle,
- Micheline Fromont-Racine,
- and Alain Jacquier
Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles
PNAS 2008 105:5821-5826; published ahead of print April 11, 2008, doi:10.1073/pnas.0710533105
Open Access Article
Select this article
Biological Sciences - Genetics:
- L. Meadow Anderson
- and Haw Yang
DNA looping can enhance lysogenic CI transcription in phage lambda
PNAS 2008 105:5827-5832; published ahead of print April 7, 2008, doi:10.1073/pnas.0705570105
Select this article
Biological Sciences - Genetics:
- Ruslan Kalendar,
- Jaakko Tanskanen,
- Wei Chang,
- Kristiina Antonius,
- Hanan Sela,
- Ofer Peleg,
- and Alan H. Schulman
Cassandra retrotransposons carry independently transcribed 5S RNA
PNAS 2008 105:5833-5838; published ahead of print April 11, 2008, doi:10.1073/pnas.0709698105

Immunology

Select this article
Biological Sciences - Immunology:
- Nina F. Rose,
- Jean Publicover,
- Anasuya Chattopadhyay,
- and John K. Rose
Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors
PNAS 2008 105:5839-5843; published ahead of print April 7, 2008, doi:10.1073/pnas.0800280105

Medical Sciences

Select this article
Biological Sciences - Medical Sciences:
- S. Keren,
- C. Zavaleta,
- Z. Cheng,
- A. de la Zerda,
- O. Gheysens,
- and S. S. Gambhir
Noninvasive molecular imaging of small living subjects using Raman spectroscopy
PNAS 2008 105:5844-5849; published ahead of print March 31, 2008, doi:10.1073/pnas.0710575105
Open Access Article
Select this article
Biological Sciences - Medical Sciences:
- Hannah H. Alphs,
- Ratish Gambhira,
- Balasubramanyam Karanam,
- Jeffrey N. Roberts,
- Subhashini Jagu,
- John T. Schiller,
- Weiguang Zeng,
- David C. Jackson,
- and Richard B. S. Roden
Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2
PNAS 2008 105:5850-5855; published ahead of print April 14, 2008, doi:10.1073/pnas.0800868105
Open Access Article
Select this article
Biological Sciences - Medical Sciences:
- Marius Wernig,
- Jian-Ping Zhao,
- Jan Pruszak,
- Eva Hedlund,
- Dongdong Fu,
- Frank Soldner,
- Vania Broccoli,
- Martha Constantine-Paton,
- Ole Isacson,
- and Rudolf Jaenisch
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
PNAS 2008 105:5856-5861; published ahead of print April 7, 2008, doi:10.1073/pnas.0801677105
Select this article
Biological Sciences - Medical Sciences:
- Meihui Pan,
- Vatsala Maitin,
- Sajesh Parathath,
- Ursula Andreo,
- Sharron X. Lin,
- Carly St. Germain,
- Zemin Yao,
- Frederick R. Maxfield,
- Kevin Jon Williams,
- and Edward A. Fisher
Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control
PNAS 2008 105:5862-5867; published ahead of print April 7, 2008, doi:10.1073/pnas.0707460104
Select this article

FROM THE COVER

In This Issue

Knockout punches with a fistful of zinc fingers

Morphing peptide backbones into heterocycles

Molecular assembly for high-performance bivalent nucleic acid inhibitor

Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β

Probing microscopic origins of confined subdiffusion by first-passage observables

Son-biased sex ratios in the 2000 United States Census

Molecular assembly for high-performance bivalent nucleic acid inhibitor

Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β

From the Cover: Identification of a vesicular nucleotide transporter

The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state

Protein kinase CK2 as an ectokinase: The role of the regulatory CK2β subunit

A relaxed active site after exon ligation by the group I intron

Activation of the lifespan regulator p66 Shc through reversible disulfide bond formation

Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner ear

An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti

Quality control of overexpressed membrane proteins

Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases

Saturation mutagenesis of putative catalytic residues of benzoylformate decarboxylase provides a challenge to the accepted mechanism

Structure of human monoamine oxidase A at 2.2-Å resolution: The control of opening the entry for substrates/inhibitors

Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes

In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate

Temperature and pressure dependence of protein stability: The engineered fluorescein-binding lipocalin FluA shows an elliptic phase diagram

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

From the Cover: Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts

Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts

Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells

Stable isotope evidence for an amphibious phase in early proboscidean evolution

Differences in spontaneous mutation frequencies as a function of environmental stress in soil fungi at “Evolution Canyon,” Israel

RNA landscape of evolution for optimal exon and intron discrimination

The genome of Bacillus coahuilensis reveals adaptations essential for survival in the relic of an ancient marine environment

From the Cover: Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

Fine structure mapping of a gene-rich region of wheat carrying Ph1 , a suppressor of crossing over between homoeologous chromosomes

Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles

DNA looping can enhance lysogenic CI transcription in phage lambda

Cassandra retrotransposons carry independently transcribed 5S RNA

Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors

Noninvasive molecular imaging of small living subjects using Raman spectroscopy

Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control