Reply to Bagni: On BC1 RNA and the fragile X mental retardation protein
- Anna Iacoangeli*,
- Timofey S. Rozhdestvensky†,
- Natalia Dolzhanskaya‡,
- Barthélémy Tournier§,
- Janin Schütt¶,
- Jürgen Brosius†,
- Robert B. Denman‡,
- Edouard W. Khandjian§,
- Stefan Kindler¶, and
- Henri Tiedge*,‖
- *The Robert F. Furchgott Center for Neural and Behavioral Science, Department of Physiology and Pharmacology, and Department of Neurology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203;
- †Institute of Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, 48149 Münster, Germany;
- ‡Department of Molecular Biology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314;
- §Département de Biologie Médicale, Faculté de Médecine, Université Laval, Québec, QC, Canada G1L 3L5; and
- ¶Institute of Human Genetics, University Hospital Hamburg–Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
In Iacoangeli et al. (1), five independent groups report that results published by Zalfa et al. (2) are not reproducible. Bagni now suggests (3) that different reagents, antibodies, or procedures might explain this lack of reproducibility. Iacoangeli et al. replicated the experimental conditions reported by Zalfa et al. whenever possible, as indicated. In several cases, however, reagents used by Zalfa et al. were not available. For instance, Zalfa et al. generated antibody rAM1 and used …
‖To whom correspondence should be addressed. E-mail: htiedge{at}downstate.edu
