Reply to Olson and Perry: H2S physiologically mediates O2 sensing
- Solomon H. Snydera,b,c,1,
- Moataz M. Gadallab, and
- Nanduri R. Prabhakard,1
- aThe Solomon H. Snyder Department of Neuroscience,
- bDepartment of Pharmacology and Molecular Sciences, and
- cDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2105; and
- dCenter for Systems Biology for O2 Sensing, Department of Medicine, University of Chicago, Chicago, IL 60637
Olson and Perry (1) commented on our recent article “H2S mediates O2 sensing in the carotid body” (2), noting that they published a study relevant to hypoxia and H2S (3). To understand the relationship of the two studies, we will summarize work from our laboratories bearing on H2S as a gasotransmitter in blood vessels (4) and the carotid body (2). Because of its chemical reactivity, H2S is known to affect multiple biological systems, including blood vessels. Whether endogenously produced H2S is a …
1To whom correspondence may be addressed. E-mail: ssnyder{at}jhmi.edu or nanduri{at}uchicago.edu.
