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DNA supercoiling enhances cooperativity and efficiency of an epigenetic switch

Kamilla Norregaard, Magnus Andersson, Kim Sneppen, Peter Eigil Nielsen, Stanley Brown and Lene B. Oddershede
PNAS October 22, 2013. 110 (43) 17386-17391; https://doi.org/10.1073/pnas.1215907110
Kamilla Norregaard
aThe Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark;
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Magnus Andersson
aThe Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark;bDepartment of Physics, Umeå University, SE-901 87 Umeå, Sweden; and
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Kim Sneppen
aThe Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark;
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Peter Eigil Nielsen
cDepartment of Cellular and Molecular Medicine, Faculty of Health and Sciences and
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Stanley Brown
dDepartment of Biology, University of Copenhagen, 2200 Copenhagen, Denmark
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Lene B. Oddershede
aThe Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark;
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  • For correspondence: oddershede@nbi.dk
  1. Edited by Sankar Adhya, National Institutes of Health, National Cancer Institute, Bethesda, MD, and approved July 8, 2013 (received for review September 12, 2012)

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DNA supercoiling sharpens an epigenetic switch
Kamilla Norregaard, Magnus Andersson, Kim Sneppen, Peter Eigil Nielsen, Stanley Brown, Lene B. Oddershede
Proceedings of the National Academy of Sciences Oct 2013, 110 (43) 17386-17391; DOI: 10.1073/pnas.1215907110

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DNA supercoiling sharpens an epigenetic switch
Kamilla Norregaard, Magnus Andersson, Kim Sneppen, Peter Eigil Nielsen, Stanley Brown, Lene B. Oddershede
Proceedings of the National Academy of Sciences Oct 2013, 110 (43) 17386-17391; DOI: 10.1073/pnas.1215907110
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