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Long-term genetic stability and a high-altitude East Asian origin for the peoples of the high valleys of the Himalayan arc

Choongwon Jeong, Andrew T. Ozga, David B. Witonsky, Helena Malmström, Hanna Edlund, Courtney A. Hofman, Richard W. Hagan, Mattias Jakobsson, Cecil M. Lewis, Mark S. Aldenderfer, Anna Di Rienzo and Christina Warinner
PNAS July 5, 2016. 113 (27) 7485-7490; published ahead of print June 20, 2016. https://doi.org/10.1073/pnas.1520844113
Choongwon Jeong
aDepartment of Human Genetics, University of Chicago, Chicago, IL 60637;
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Andrew T. Ozga
bDepartment of Anthropology, University of Oklahoma, Norman, OK 73019;
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David B. Witonsky
aDepartment of Human Genetics, University of Chicago, Chicago, IL 60637;
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Helena Malmström
cDepartment of Organismal Biology, Uppsala University, Uppsala SE-752 36, Sweden;
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Hanna Edlund
cDepartment of Organismal Biology, Uppsala University, Uppsala SE-752 36, Sweden;
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Courtney A. Hofman
bDepartment of Anthropology, University of Oklahoma, Norman, OK 73019;
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Richard W. Hagan
bDepartment of Anthropology, University of Oklahoma, Norman, OK 73019;
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Mattias Jakobsson
cDepartment of Organismal Biology, Uppsala University, Uppsala SE-752 36, Sweden;
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Cecil M. Lewis
bDepartment of Anthropology, University of Oklahoma, Norman, OK 73019;
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Mark S. Aldenderfer
dSchool of Social Sciences, Humanities, and Arts, University of California, Merced, CA 95343;
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  • For correspondence: christina.warinner@ou.edumaldenderfer@ucmerced.edudirienzo@bsd.uchicago.edu
Anna Di Rienzo
aDepartment of Human Genetics, University of Chicago, Chicago, IL 60637;
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  • For correspondence: christina.warinner@ou.edumaldenderfer@ucmerced.edudirienzo@bsd.uchicago.edu
Christina Warinner
bDepartment of Anthropology, University of Oklahoma, Norman, OK 73019;eInstitute of Evolutionary Medicine, University of Zurich, Zurich CH-8057, Switzerland
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  • ORCID record for Christina Warinner
  • For correspondence: christina.warinner@ou.edumaldenderfer@ucmerced.edudirienzo@bsd.uchicago.edu
  1. Edited by Lynn B. Jorde, University of Utah, Salt Lake City, UT, and accepted by Editorial Board Member Richard G. Klein May 17, 2016 (received for review October 21, 2015)

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Article Information

vol. 113 no. 27 7485-7490
DOI: 
https://doi.org/10.1073/pnas.1520844113
PubMed: 
27325755

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in print July 5, 2016.
  • Published first June 20, 2016.

Copyright & Usage: 
Freely available online through the PNAS open access option.

Author Information

  1. Choongwon Jeonga,
  2. Andrew T. Ozgab,
  3. David B. Witonskya,
  4. Helena Malmströmc,
  5. Hanna Edlundc,
  6. Courtney A. Hofmanb,
  7. Richard W. Haganb,
  8. Mattias Jakobssonc,
  9. Cecil M. Lewisb,
  10. Mark S. Aldenderferd,1,
  11. Anna Di Rienzoa,1, and
  12. Christina Warinnerb,e,1
  1. aDepartment of Human Genetics, University of Chicago, Chicago, IL 60637;
  2. bDepartment of Anthropology, University of Oklahoma, Norman, OK 73019;
  3. cDepartment of Organismal Biology, Uppsala University, Uppsala SE-752 36, Sweden;
  4. dSchool of Social Sciences, Humanities, and Arts, University of California, Merced, CA 95343;
  5. eInstitute of Evolutionary Medicine, University of Zurich, Zurich CH-8057, Switzerland
  1. Edited by Lynn B. Jorde, University of Utah, Salt Lake City, UT, and accepted by Editorial Board Member Richard G. Klein May 17, 2016 (received for review October 21, 2015)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: christina.warinner{at}ou.edu, maldenderfer{at}ucmerced.edu, or dirienzo{at}bsd.uchicago.edu.
  • Author contributions: C.M.L., M.S.A., A.D.R., and C.W. designed research; A.T.O., H.M., H.E., C.A.H., R.W.H., M.S.A., and C.W. performed research; M.J. and A.D.R. contributed new reagents/analytic tools; C.J., D.B.W., and C.W. analyzed data; and C.J. and C.W. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission. L.B.J. is a guest editor invited by the Editorial Board.

  • Data deposition: Metagenomic DNA sequences have been deposited in the NCBI Short Read Archive (SRA) (project accession no. SRP065070 and sample accession nos. SRR2751055–SRR2751058, SRR2751060–SRR2751063, SRR2751066–SRR2751067, SRR2751070, SRR2751142, SRR2751148, SRR2751152, SRR3222643, SRR3222649, SRR3222655, SRR3222659, SRR3222661, SRR3222664, SRR3222686, SRR3222749, SRR3222758, SRR3222765, and SRR3222772).

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1520844113/-/DCSupplemental.

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Online Impact

Article usage

Article usage: June 2016 to April 2018

AbstractFullPdf
Jun 201630291521684
Jul 20164916498620
Aug 2016552223124
Sep 2016299101111
Oct 2016279161123
Nov 2016203100113
Dec 20162137265
Total 2016949126761840
Jan 2017329138136
Feb 20172019163
Mar 20171867583
Apr 20171849082
May 201717723981
Jun 201712310559
Jul 20171646748
Aug 20171276361
Sep 20171598071
Oct 20171519065
Nov 20171607757
Dec 2017719142
Total 201720321206848
Jan 2018779343
Feb 201814914836
Mar 201812914753
Apr 2018627240
Total 2018417460172
Total1194043422860
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Population history of the Himalayan arc
Choongwon Jeong, Andrew T. Ozga, David B. Witonsky, Helena Malmström, Hanna Edlund, Courtney A. Hofman, Richard W. Hagan, Mattias Jakobsson, Cecil M. Lewis, Mark S. Aldenderfer, Anna Di Rienzo, Christina Warinner
Proceedings of the National Academy of Sciences Jul 2016, 113 (27) 7485-7490; DOI: 10.1073/pnas.1520844113

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Population history of the Himalayan arc
Choongwon Jeong, Andrew T. Ozga, David B. Witonsky, Helena Malmström, Hanna Edlund, Courtney A. Hofman, Richard W. Hagan, Mattias Jakobsson, Cecil M. Lewis, Mark S. Aldenderfer, Anna Di Rienzo, Christina Warinner
Proceedings of the National Academy of Sciences Jul 2016, 113 (27) 7485-7490; DOI: 10.1073/pnas.1520844113
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