Regulation of Axon Formation by Clonal Lines of a Neural Tumor

  1. N. W. Seeds*,
  2. A. G. Gilman,
  3. T. Amano, and
  4. M. W. Nirenberg
  1. LABORATORY OF BIOCHEMICAL GENETICS, NATIONAL INSTITUTES OF HEALTH, BETHESDA, MARYLAND

Abstract

Clonal lines of neuroblastoma cells were found to extend or retract axons depending upon the concentration of serum. Neurite extension was not inhibited by cycloheximide but was sensitive to colchicine or vinblastine, suggesting that neurite formation is dependent upon the assembly of microtubules or neurofilaments from preformed protein subunits.

Footnotes

  • ↵ * Postdoctoral fellow of the National Science Foundation (48034).

« Previous | Next Article »Table of Contents

This Article

  1. PNAS May 1, 1970 vol. 66 no. 1 160-167
  1. » Abstract
  2. Full Text (PDF)

Readers Also Viewed

Link: Advanced Search

This Week's Issue

  1. November 24, 2009, 106 (47)
  1. Current Issue
  1. Alert me to new issues of PNAS

Most