Epidermal Growth Factor: High and Low Molecular Weight Forms

  1. John M. Taylor,
  2. Stanley Cohen, and
  3. William M. Mitchell
  1. DEPARTMENT OF BIOCHEMISTRY, VANDERBILT UNIVERSITY, NASHVILLE, TENNESSEE 37203
  2. DEPARTMENT OF MICROBIOLOGY, VANDERBILT UNIVERSITY, NASHVILLE, TENNESSEE 37203

Abstract

In crude homogenates of the submaxillary gland of the male mouse, epidermal growth factor (EGF) activity was found almost entirely in a high molecular weight complex (about 74,000 daltons). This high molecular weight form may be reversibly dissociated into EGF and an EGF-binding protein. EGF was found to have a molecular weight of approximately 6400. The EGF-binding protein has a molecular weight of 29,000, and shows arginyl-esterase activity.

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  1. PNAS September 1, 1970 vol. 67 no. 1 164-171
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