Conversion-Associated Recombination in Yeast

  1. Donald D. Hurst*,
  2. Seymour Fogel, and
  3. Robert K. Mortimer
  1. Department of Genetics, University of California, Berkeley, Calif. 94720
  2. Division of Medical Physics, University of California, Berkeley, Calif. 94720

Abstract

Gene conversion and conversion-associated reciprocal recombination have been studied in various Saccharomyces cerevisiae hybrids. In a sample of 11,023 unselected meiotic tetrads, 907 conversions were observed at the arg4, thr3, his1, and SUP6 loci. Of these conversions, 445 (or 49.1%) were associated with reciprocal recombination of bracketing markers no more than 20-centimorgans apart. For conversions of two other loci, his2 and thr1, for which the bracketing markers were more than 20-centimorgans apart, recombination frequencies were significantly greater than 50%. These findings are discussed in terms of current models of genetic recombination. It is suggested that all meiotic crossing-over is characterized by the recombination events that are associated with conversion.

Footnotes

  • ↵ * On leave from Brooklyn College, City University of New York.

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  1. PNAS January 1, 1972 vol. 69 no. 1 101-105
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