The Antibody Response of Mice to Murine Leukemia Virus in Spontaneous Infection: Absence of Classical Immunologic Tolerance

  1. Michael B. A. Oldstone,
  2. Tadao Aoki*, and
  3. Frank J. Dixon
  1. Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
  2. Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York, N.Y. 10021

Abstract

Gross murine leukemia virus is the etiologic agent of spontaneous leukemias of AKR mice. Despite the persistence of the Gross virus throughout their life, these mice are not immunologically tolerant to the virus. Specific antibodies to Gross antigens can be detected in the kidney where they have been deposited in the glomeruli, apparently in the form of Gross antigen-antibody complexes.

Footnotes

  • ↵ * Present address: Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Md. 20014

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  1. PNAS January 1, 1972 vol. 69 no. 1 134-138
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