Synthesis of Epstein-Barr Virus After Activation of the Viral Genome in a “Virus-Negative” Human Lymphoblastoid Cell (Raji) Made Resistant to 5-Bromodeoxyuridine

  1. Berge Hampar*,
  2. Jeffery G. Derge†,
  3. Lidia M. Martos†, and
  4. John L. Walker†
  1. *Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
  2. †Flow Laboratories, Inc., Rockville, Md. 20852

Abstract

The Raji line of human lymphoblastoid cells, which does not show expression of Epstein-Barr virus, was made resistant to 5-bromodeoxyuridine. Within several weeks after removal of the drug, Epstein-Barr virus particles were detected in the cells. The sequence of virus appearance in the 5-bromodeoxyuridine-resistant cells indicated drug-induced activation of a repressed Epstein-Barr virus genome.

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  1. PNAS January 1, 1972 vol. 69 no. 1 78-82
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