Dog Homologue of Human β2-Microglobulin

  1. O. Smithies* and
  2. M. D. Poulik†,‡
  1. *The Genetics Laboratory, University of Wisconsin, Madison, Wis. 53706
  2. †The Research Institute, William Beaumont Hospital, Royal Oak, Michigan 48072
  3. ‡Wayne State University School of Medicine, Detroit, Michigan 48202

Abstract

The amino-acid sequence of human β2-microglobulin, a protein of 100 residues, is related to parts of the constant region of IgG heavy chain. The dog homologue of human β2-microglobulin has now been isolated and its amino-acid sequence has been partially determined. The two proteins (human and dog β2-microglobulins) are demonstrably different at only 6 or 7 of the 42 positions examined. Use of the dog should permit experimental investigation of the functional relationships of β2-microglobulin to immunoglobulins and the immune system. β2-Microglobulin has also been detected in serum from a chimpanzee. The gene for β2-microglobulin may correspond to the end portion of an immunoglobulin heavy chain gene.

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  1. PNAS October 1, 1972 vol. 69 no. 10 2914-2917
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