Hydrocortisone Induction of Rat-Liver Leucyl-Transfer RNA and Its Synthetases

  1. Kurt Altman,
  2. A. Louis Southren,
  3. Stanley C. Uretsky*,†,
  4. Peter Zabos†, and
  5. George Acs†
  1. Department of Medicine, Section of Endocrinology, New York Medical College, New York, N.Y. 10029
  2. †Department of Enzymology, Institute for Muscle Disease, Inc., New York, N.Y. 10021

Abstract

Within 3 hr after the intraperitoneal administration of hydrocortisone to female rats, a new leucine-accepting tRNA and a new leucyl-tRNA synthetase activity appear in the liver cytosol. The new isoaccepting tRNA can be acylated only with the synthetase derived from livers of hormone-treated animals. Both components are transient; by 12 hr after hydrocortisone administration, the isoaccepting tRNA and its synthetase disappear from livers of treated animals.

Footnotes

  • ↵ * Present address: Department of Pediatrics, The Mount Sinai School of Medicine, New York, N.Y. 10029.

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  1. PNAS December 1, 1972 vol. 69 no. 12 3567-3569
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