Nuclear Magnetic Resonance Spectrum of Lysine-Vasopressin in Aqueous Solution and Its Structural Implications

  1. P. H. Von Dreele*,
  2. A. I. Brewster†,
  3. J. Dadok‡,
  4. H. A. Scheraga*,
  5. F. A. Bovey†,
  6. M. F. Ferger*, and
  7. V. Du Vigneaud*
  1. *Department of Chemistry, Cornell University, Ithaca, New York 14850
  2. †Bell Telephone Laboratories, Murray Hill, New Jersey 07974
  3. ‡Department of Chemistry, Carnegie-Mellon University, Pittsburgh, Pennsylvania 15213

Abstract

The peaks in the proton NMR spectrum of lysine-vasopressin in aqueous solution at pH 3-5 were assigned to particular amino-acid residues by the use of the results of dilution studies and NH-CαH and CαH-CβH decoupling experiments. The conformation of lysine-vasopressin in water differs from its conformation in dimethylsulfoxide.

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  1. PNAS 1972-08 vol. 69 no. 8 2169-2173
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