Complementation Studies of Lethal Alleles in the Mouse Causing Deficiencies of Glucose-6-Phosphatase, Tyrosine Aminotransferase, and Serine Dehydratase

  1. Salome Gluecksohn-Waelsch*,†,
  2. Michael B. Schiffman*,
  3. Janet Thorndike‡, and
  4. Carl F. Cori‡
  1. *Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
  2. ‡Enzyme Research Laboratory Massachusetts General Hospital, Boston, Mass. 02114
  3. Department of Biological Chemistry, Harvard Medical School, Boston, Mass. 02114

Abstract

The pleiotropic effects of six radiation-induced lethal alleles at the albino locus in the mouse include deficiencies of various enzymes and of serum proteins. Closely correlated with the biochemical deficiencies are severe ultrastructural abnormalities of endoplasmic reticulum membranes and the Golgi apparatus in liver and kidney cells. Complementation studies led to the distinction of four different complementation groups among the six lethal alleles. The results are compatible with the interpretation that the six lethal alleles represent overlapping deletions of various sizes at and around the albino locus in the mouse, in a region concerned with the control of biochemical and structural differentiation.

Footnotes

  • ↵ † Address reprint requests to this author.

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  1. PNAS March 1, 1974 vol. 71 no. 3 825-829
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