Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor

  1. G Conn,
  2. M L Bayne,
  3. D D Soderman,
  4. P W Kwok,
  5. K A Sullivan,
  6. T M Palisi,
  7. D A Hope, and
  8. K A Thomas
  1. Department of Biochemistry, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.

Abstract

Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.

« Previous | Next Article »Table of Contents

This Article

  1. PNAS April 1, 1990 vol. 87 no. 7 2628-2632
  1. » Abstract
  2. Full Text (PDF)

Readers Also Viewed

Classifications

Link: Advanced Search

This Week's Issue

  1. November 24, 2009, 106 (47)
  1. Current Issue
  1. Alert me to new issues of PNAS

Most