A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

  1. W Matthews,
  2. C T Jordan,
  3. M Gavin,
  4. N A Jenkins,
  5. N G Copeland, and
  6. I R Lemischka
  1. Department of Molecular Biology, Princeton University, NJ 08544.

Abstract

We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.

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  1. PNAS October 15, 1991 vol. 88 no. 20 9026-9030
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