Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element

  1. P Leroy,
  2. H Nakshatri, and
  3. P Chambon
  1. Laboratoire de Génétique Moléculaire des Eucaryotes, Unité 184 de Biologie Moléculaire et de Génie Génétique, Institut National de la Santé et de la Recherche Médicale, Strasbourg, France.

Abstract

We have characterized the promoter of the mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-beta 2 promoter. Moreover, RAR-alpha 2 and RAR-beta 2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-alpha 2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (alpha, beta, and gamma) bind in vitro.

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  1. PNAS November 15, 1991 vol. 88 no. 22 10138-10142
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