Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells

  1. R J Rotello,
  2. R C Lieberman,
  3. A F Purchio, and
  4. L E Gerschenson
  1. Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.

Abstract

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.

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  1. PNAS April 15, 1991 vol. 88 no. 8 3412-3415
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