Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation

  1. M S Kapiloff,
  2. J M Mathis,
  3. C A Nelson,
  4. C R Lin, and
  5. M G Rosenfeld
  1. Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093-0648.

Abstract

Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.

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  1. PNAS May 1, 1991 vol. 88 no. 9 3710-3714
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