Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues

  1. C A Ross,
  2. S K Danoff,
  3. M J Schell,
  4. S H Snyder, and
  5. A Ullrich
  1. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2195.

Abstract

Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned from a mouse placenta cDNA library. All three display strong homology in membrane-spanning domains M7 and M8 to the originally cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting heterogeneity of IP3 action within a single cell.

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  1. PNAS May 15, 1992 vol. 89 no. 10 4265-4269
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