Inverted repeat structure of the Sry locus in mice

  1. J Gubbay,
  2. N Vivian,
  3. A Economou,
  4. D Jackson,
  5. P Goodfellow, and
  6. R Lovell-Badge
  1. Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, United Kingdom.

Abstract

The testis-determining gene Sry is located on the short arm of the mouse Y chromosome in a region known to have undergone duplications and rearrangements in comparison with the equivalent portion of the human Y chromosome. Detailed analysis of the Sry genomic locus reveals a further difference in that the mouse Sry open reading frame lies within 2.8 kilobases of unique sequence at the center of a large inverted repeat. This repeat, which is found in both Mus musculus musculus and Mus musculus domesticus Y chromosomes, is not present at the human SRY locus. Recombination involving the repeat region may have led to an 11-kilobase deletion, precisely excising Sry in a line of XY female mice.

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  1. PNAS September 1, 1992 vol. 89 no. 17 7953-7957
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