"BFA bodies": a subcompartment of the endoplasmic reticulum

  1. L Orci,
  2. A Perrelet,
  3. M Ravazzola,
  4. F T Wieland,
  5. R Schekman, and
  6. J E Rothman
  1. Department of Morphology, University of Geneva Medical School, Switzerland.

Abstract

A specialized region of the endoplasmic reticulum--the BFA body--is defined by the site of accumulation of coatomer when nonclathrin coat protein (COP)-coated vesicle assembly is prevented by the drug brefeldin A (BFA). BFA bodies are formed by part smooth, part rough domains of endoplasmic reticulum that are cis to the classical transitional endoplasmic reticulum and to BFA-induced Golgi remnants.

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  1. PNAS December 1, 1993 vol. 90 no. 23 11089-11093
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