Participation of cyclin A in Myc-induced apoptosis

  1. A T Hoang,
  2. K J Cohen,
  3. J F Barrett,
  4. D A Bergstrom, and
  5. C V Dang
  1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Abstract

The involvement of c-Myc in cellular proliferation or apoptosis has been linked to differential cyclin gene expression. We observed that in both proliferating cells and cells undergoing apoptosis, cyclin A (but not B, C, D1, and E) mRNA level was elevated in unsynchronized Myc-overexpressing cells when compared with parental Rat1a fibroblasts. We further demonstrated that Zn(2+)-inducible cyclin A expression was sufficient to cause apoptosis. When Myc-induced apoptosis was blocked by coexpression of Bcl-2, the levels of cyclin C, D1, and E mRNAs were also elevated. Thus, while apoptosis induced by c-Myc is associated with an elevated cyclin A mRNA level, protection from apoptosis by coexpressed Bcl-2 is associated with a complementary increase in cyclin C, D1, and E mRNAs.

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  1. PNAS July 19, 1994 vol. 91 no. 15 6875-6879
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