Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas

  1. J Weaver-Feldhaus,
  2. N A Gruis,
  3. S Neuhausen,
  4. D Le Paslier,
  5. E Stockert,
  6. M H Skolnick, and
  7. A Kamb
  1. Myriad Genetics, Inc., Salt Lake City, UT 84108.

Abstract

The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set of sequence-tagged sites in this region has been developed. By using these markers and others previously reported, the 9p21 region has been studied by physical mapping in 84 melanoma cell lines. A putative tumor suppressor gene, perhaps MLM itself, has been localized to a region of less than 40 kb that lies proximal (centromeric) to the alpha-interferon gene cluster.

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  1. PNAS August 2, 1994 vol. 91 no. 16 7563-7567
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