Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice

  1. B Favier,
  2. M Le Meur,
  3. P Chambon, and
  4. P Dollé
  1. Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur/Collège de France, Strasbourg, France.

Abstract

The Hoxd-11 gene was disrupted by homologous recombination in embryonic stem cells. We found that Hoxd-11-/- mutant mice are viable and display homeotic transformations of their sacral vertebrae, while their forelimbs present abnormalities of some metacarpals and of the first row of carpal bones. These results are discussed in the light of current models of tetrapod axial skeleton and limb patterning.

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  1. PNAS January 3, 1995 vol. 92 no. 1 310-314
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