Drug delivery: piercing vesicles by their adsorption onto a porous medium

  1. M A Guedeau-Boudeville,
  2. L Jullien, and
  3. J M di Meglio
  1. Laboratoire de Physique de la Matière Condensée, Unité de Recherche Associée 792 du Centre National de la Recherche Scientifique, Collège de France, Paris, France.

Abstract

Experimental evidence is presented that supports the possibility of building a "molecular drill." By the adsorption of a vesicle onto a porous substrate (specifically, a lycopode grain), it was possible to increase the permeability of the vesicle by locally stretching its membrane. Molecules contained within the vesicle, which could not cross the membrane, were delivered to the porous substrate upon adsorption. This general process could provide another method for drug delivery and targeting.

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  1. PNAS October 10, 1995 vol. 92 no. 21 9590-9592
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