Continuation of neurogenesis in the hippocampus of the adult macaque monkey
-
Contributed by Pasko Rakic
Abstract
We present evidence for continuous generation of neurons, oligodendrocytes, and astrocytes in the hippocampal dentate gyrus of adult macaque monkeys, using immunohistochemical double labeling for bromodeoxyuridine and cell-type-specific markers. We estimate that the relative rate of neurogenesis is approximately 10 times less than that reported in the adult rodent dentate gyrus. Nevertheless, the generation of these three cell types in a discreet brain region suggests that a multipotent neural stem cell may be retained in the adult primate hippocampus. This demonstration of adult neurogenesis in nonhuman Old World primates—with their phylogenetic proximity to humans, long life spans, and elaborate cognitive abilities—establishes the macaque as an unexcelled animal model to experimentally investigate issues of neurogenesis in humans and offers new insights into its significance in the adult brain.
Footnotes
-
↵* To whom reprint requests should be addressed at: Section of Neurobiology, Yale University School of Medicine, C303 SHM, P.O. Box 208001, New Haven, CT 06510-8001.
ABBREVIATIONS
- BrdU,
- bromodeoxyuridine;
- GCL,
- granule cell layer;
- SGZ,
- subgranular zone;
- PCNA,
- proliferating-cell nuclear antigen;
- CNP,
- 2′,3′-cyclic nucleotide 3′-phosphodiesterase
- Accepted March 19, 1999.
- Copyright © 1999, The National Academy of Sciences
