Skip to main content
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Rights and Permissions
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Current
    • Latest Articles
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • Archive
  • Front Matter
  • News
    • For the Press
    • Highlights from Latest Articles
    • PNAS in the News
  • Podcasts
  • Authors
    • Purpose and Scope
    • Editorial and Journal Policies
    • Submission Procedures
    • For Reviewers
    • Author FAQ
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Rights and Permissions
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Home
Home

Advanced Search

  • Home
  • Articles
    • Current
    • Latest Articles
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • Archive
  • Front Matter
  • News
    • For the Press
    • Highlights from Latest Articles
    • PNAS in the News
  • Podcasts
  • Authors
    • Purpose and Scope
    • Editorial and Journal Policies
    • Submission Procedures
    • For Reviewers
    • Author FAQ

New Research In

Physical Sciences

Featured Portals

  • Physics
  • Chemistry
  • Sustainability Science

Articles by Topic

  • Applied Mathematics
  • Applied Physical Sciences
  • Astronomy
  • Computer Sciences
  • Earth, Atmospheric, and Planetary Sciences
  • Engineering
  • Environmental Sciences
  • Mathematics
  • Statistics

Social Sciences

Featured Portals

  • Anthropology
  • Sustainability Science

Articles by Topic

  • Economic Sciences
  • Environmental Sciences
  • Political Sciences
  • Psychological and Cognitive Sciences
  • Social Sciences

Biological Sciences

Featured Portals

  • Sustainability Science

Articles by Topic

  • Agricultural Sciences
  • Anthropology
  • Applied Biological Sciences
  • Biochemistry
  • Biophysics and Computational Biology
  • Cell Biology
  • Developmental Biology
  • Ecology
  • Environmental Sciences
  • Evolution
  • Genetics
  • Immunology and Inflammation
  • Medical Sciences
  • Microbiology
  • Neuroscience
  • Pharmacology
  • Physiology
  • Plant Biology
  • Population Biology
  • Psychological and Cognitive Sciences
  • Sustainability Science
  • Systems Biology

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

Haruo Ikeda, Tomoko Nonomiya, Masayo Usami, Toshio Ohta and Satoshi Ōmura
PNAS August 17, 1999. 96 (17) 9509-9514; https://doi.org/10.1073/pnas.96.17.9509
Haruo Ikeda
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tomoko Nonomiya
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masayo Usami
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toshio Ohta
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Satoshi Ōmura
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  1. Contributed by Satoshi Ōmura

  • Article
  • Authors & Info
  • PDF
Loading

Article Information

vol. 96 no. 17 9509-9514
DOI: 
https://doi.org/10.1073/pnas.96.17.9509
PubMed: 
10449723

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Accepted June 23, 1999
  • Published August 17, 1999.

Copyright & Usage: 
Copyright © 1999, The National Academy of Sciences

Author Information

  1. Haruo Ikeda*,
  2. Tomoko Nonomiya†,
  3. Masayo Usami*,
  4. Toshio Ohta†, and
  5. Satoshi Ōmura*†‡
  1. *School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan; and †Research Center for Biological Function, The Kitasato Institute, Tokyo 108-8642, Japan
  1. Contributed by Satoshi Ōmura

Footnotes

    • ↵‡ To whom reprint requests should be addressed. E-mail: omura-s{at}kitasato.or.jp.

    Cited By...

    • 233 Citations
    • 246 Citations
    • 173 Citations
    • Google Scholar

    This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

    • The Biosynthetic Logic of Polyketide Diversity
      Christian Hertweck
      Angewandte Chemie International Edition 2009 48 26
    • Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system
      Daniel Tillett, Elke Dittmann, Marcel Erhard, Hans von Döhren, Thomas Börner, Brett A Neilan
      Chemistry & Biology 2000 7 10
    • Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
      S. Omura, H. Ikeda, J. Ishikawa, A. Hanamoto, C. Takahashi, M. Shinose, Y. Takahashi, H. Horikawa, H. Nakazawa, T. Osonoe, H. Kikuchi, T. Shiba, Y. Sakaki, M. Hattori
      Proceedings of the National Academy of Sciences 2001 98 21
    • Genomic basis for natural product biosynthetic diversity in the actinomycetes
      Markus Nett, Haruo Ikeda, Bradley S. Moore
      Natural Product Reports 2009 26 11
    • Natural-Product Sugar Biosynthesis and Enzymatic Glycodiversification
      Christopher J. Thibodeaux, Charles E. Melançon, Hung-wen Liu
      Angewandte Chemie International Edition 2008 47 51
    • The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
      I Molnár, T Schupp, M Ono, RE Zirkle, M Milnamow, B Nowak-Thompson, N Engel, C Toupet, A Stratmann, DD Cyr, J Gorlach, JM Mayo, A Hu, S Goff, J Schmid, JM Ligon
      Chemistry & Biology 2000 7 2
    • Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics
      Stefano Donadio, Paolo Monciardini, Margherita Sosio
      Natural Product Reports 2007 24 5
    • New PCR Primers for the Screening of NRPS and PKS-I Systems in Actinomycetes: Detection and Distribution of These Biosynthetic Gene Sequences in Major Taxonomic Groups
      A. Ayuso-Sacido, O. Genilloud
      Microbial Ecology 2005 49 1
    • Die biosynthetische Grundlage der Polyketid‐Vielfalt
      Christian Hertweck
      Angewandte Chemie 2009 121 26
    • Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules
      Richard W. Gantt, Pauline Peltier-Pain, Jon S. Thorson
      Natural Product Reports 2011 28 11
    • Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway
      Trygve Brautaset, Olga N Sekurova, Håvard Sletta, Trond E Ellingsen, Arne R Strøm, Svein Valla, Sergey B Zotchev
      Chemistry & Biology 2000 7 6
    • Computational Approach for Prediction of Domain Organization and Substrate Specificity of Modular Polyketide Synthases
      Gitanjali Yadav, Rajesh S Gokhale, Debasisa Mohanty
      Journal of Molecular Biology 2003 328 2
    • Iteration as Programmed Event during Polyketide Assembly; Molecular Analysis of the Aureothin Biosynthesis Gene Cluster
      Jing He, Christian Hertweck
      Chemistry & Biology 2003 10 12
    • Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa11The DNA sequence reported here was deposited in GenBank under the accession number AY007564.
      Clive Waldron, Patti Matsushima, Paul R Rosteck, Mary C Broughton, Jan Turner, Krishnamurthy Madduri, Kathryn P Crawford, Donald J Merlo, Richard H Baltz
      Chemistry & Biology 2001 8 5
    • Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
      Elizabeth S. Sattely, Michael A. Fischbach, Christopher T. Walsh
      Natural Product Reports 2008 25 4
    • Altering the glycosylation pattern of bioactive compounds
      Carmen Méndez, José A Salas
      Trends in Biotechnology 2001 19 11
    • Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum
      Bryan Julien, Sanjay Shah, Rainer Ziermann, Robert Goldman, Leonard Katz, Chaitan Khosla
      Gene 2000 249 1-2
    • Yersiniabactin Synthetase
      Deborah Ann Miller, Lusong Luo, Nathan Hillson, Thomas A Keating, Christopher T Walsh
      Chemistry & Biology 2002 9 3
    • A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis
      Jesús F Aparicio, Roberto Fouces, Marta V Mendes, Noemı́ Olivera, Juan F Martı́n
      Chemistry & Biology 2000 7 11
    • Hybrid Peptide–Polyketide Natural Products: Biosynthesis and Prospects toward Engineering Novel Molecules
      Liangcheng Du, César Sánchez, Ben Shen
      Metabolic Engineering 2001 3 1
    • Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization
      Markiyan Oliynyk, Christian B. W. Stark, Apoorva Bhatt, Michelle A. Jones, Zoë A. Hughes-Thomas, Christopher Wilkinson, Zoryana Oliynyk, Yuliya Demydchuk, James Staunton, Peter F. Leadlay
      Molecular Microbiology 2003 49 5
    • A Complete Gene Cluster from Streptomyces nanchangensis NS3226 Encoding Biosynthesis of the Polyether Ionophore Nanchangmycin
      Yuhui Sun, Xiufen Zhou, Hui Dong, Guoquan Tu, Min Wang, Bofei Wang, Zixin Deng
      Chemistry & Biology 2003 10 5
    • Evolution of polyketide synthases in bacteria
      C. P. Ridley, H. Y. Lee, C. Khosla
      Proceedings of the National Academy of Sciences 2008 105 12
    • Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga1511This article is dedicated to Prof. Dr. E. Leistner on the occasion of his 60th birthday.
      Barbara Silakowski, Gabriele Nordsiek, Brigitte Kunze, Helmut Blöcker, Rolf Müller
      Chemistry & Biology 2001 8 1
    • A New Golden Age of Natural Products Drug Discovery
      Ben Shen
      Cell 2015 163 6
    • Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters
      Haruo Ikeda, Kazuo Shin-ya, Satoshi Omura
      Journal of Industrial Microbiology & Biotechnology 2014 41 2
    • ‘Streptomyces nanchangensis’, a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide meilingmycin, contains multiple polyketide gene clusters
      Jun Liu, Zixin Deng, Guiming Zhang, Tobias Kieser, Xiufen Zhou, Yuhui Sun, Kai Bao, Guoquan Tu
      Microbiology 2002 148 2
    • Engineering Deoxysugar Biosynthetic Pathways from Antibiotic-Producing Microorganisms
      Leticia Rodrı́guez, Ignacio Aguirrezabalaga, Nerea Allende, Alfredo F Braña, Carmen Méndez, José A Salas
      Chemistry & Biology 2002 9 6
    • A novel class of self-sufficient cytochrome P450 monooxygenases in prokaryotes
      René De Mot, Annabel H.A Parret
      Trends in Microbiology 2002 10 11
    • Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation
      Shunji Takahashi, Atsushi Toyoda, Yasuyo Sekiyama, Hiroshi Takagi, Toshihiko Nogawa, Masakazu Uramoto, Ryuichiro Suzuki, Hiroyuki Koshino, Takuto Kumano, Suresh Panthee, Tohru Dairi, Jun Ishikawa, Haruo Ikeda, Yoshiyuki Sakaki, Hiroyuki Osada
      Nature Chemical Biology 2011 7 7
    • Molecular and Biochemical Studies of Chondramide Formation—Highly Cytotoxic Natural Products from Chondromyces crocatus Cm c5
      Shwan Rachid, Daniel Krug, Brigitte Kunze, Irene Kochems, Maren Scharfe, T. Mark Zabriskie, Helmut Blöcker, Rolf Müller
      Chemistry & Biology 2006 13 6
    • Novel mutation breeding method forStreptomyces avermitilisusing an atmospheric pressure glow discharge plasma
      L.-Y. Wang, Z.-L. Huang, G. Li, H.-X. Zhao, X.-H. Xing, W.-T. Sun, H.-P. Li, Z.-X. Gou, C.-Y. Bao
      Journal of Applied Microbiology 2010 108 3
    • Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?
      S. L. Kelly, D. E. Kelly
      Philosophical Transactions of the Royal Society B: Biological Sciences 2013 368 1612
    • Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules
      R. D. Kersten, N. Ziemert, D. J. Gonzalez, B. M. Duggan, V. Nizet, P. C. Dorrestein, B. S. Moore
      Proceedings of the National Academy of Sciences 2013 110 47
    • Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis
      Shigeru Kitani, Haruo Ikeda, Takako Sakamoto, Satoru Noguchi, Takuya Nihira
      Applied Microbiology and Biotechnology 2009 82 6
    • Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2)
      David C. Lamb, Haruo Ikeda, David R. Nelson, Jun Ishikawa, Tove Skaug, Colin Jackson, Satoshi Omura, Michael R. Waterman, Steven L. Kelly
      Biochemical and Biophysical Research Communications 2003 307 3
    • Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii
      Shuhao Wang, Yuquan Xu, Erin A. Maine, E.M. Kithsiri Wijeratne, Patricia Espinosa-Artiles, A.A. Leslie Gunatilaka, István Molnár
      Chemistry & Biology 2008 15 12
    • DNA-binding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus
      Haruka Yamazaki, Ayami Tomono, Yasuo Ohnishi, Sueharu Horinouchi
      Molecular Microbiology 2004 53 2
    • The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster
      D Hoffmeister, K Ichinose, S Domann, B Faust, A Trefzer, G Dräger, A Kirschning, C Fischer, E Künzel, DW Bearden, J Rohr, A Bechthold
      Chemistry & Biology 2000 7 11
    • The Enzymology of Combinatorial Biosynthesis
      Christopher D. Reeves
      Critical Reviews in Biotechnology 2003 23 2
    • Type I Polyketide Synthases May Have Evolved Through Horizontal Gene Transfer
      Aurélien Ginolhac, Cyrille Jarrin, Patrick Robe, Guy Perrière, Timothy M. Vogel, Pascal Simonet, Renaud Nalin
      Journal of Molecular Evolution 2005 60 6
    • Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis
      Kim Stutzman-Engwall, Steve Conlon, Ronald Fedechko, Hamish McArthur, Katja Pekrun, Yan Chen, Stephane Jenne, Charlene La, Na Trinh, Seran Kim, Ying-Xin Zhang, Richard Fox, Claes Gustafsson, Anke Krebber
      Metabolic Engineering 2005 7 1
    • Engineering Biosynthetic Pathways for Deoxysugars: Branched-Chain Sugar Pathways and Derivatives from the Antitumor Tetracenomycin
      Felipe Lombó, Miranda Gibson, Lisa Greenwell, Alfredo F. Braña, Jürgen Rohr, José A. Salas, Carmen Méndez
      Chemistry & Biology 2004 11 12
    • The 1.92-Å Structure ofStreptomyces coelicolorA3(2) CYP154C1
      Larissa M. Podust, Youngchang Kim, Miharu Arase, Benjamin A. Neely, Brian J. Beck, Horacio Bach, David H. Sherman, David C. Lamb, Steven L. Kelly, Michael R. Waterman
      Journal of Biological Chemistry 2003 278 14
    • Microbial aldo-keto reductases
      Elizabeth M Ellis
      FEMS Microbiology Letters 2002 216 2
    • Studies on Biosynthetic Genes and Enzymes of Isoprenoids Produced by Actinomycetes
      Tohru Dairi
      The Journal of Antibiotics 2005 58 4
    • Functional Analysis of the Aureothin Iterative Type I Polyketide Synthase
      Jing He, Christian Hertweck
      ChemBioChem 2005 6 5
    • Genome analyses of Streptomyces peucetius ATCC 27952 for the identification and comparison of cytochrome P450 complement with other Streptomyces
      Niranjan Parajuli, Devi B. Basnet, Hei Chan Lee, Jae Kyung Sohng, Kwangkyoung Liou
      Archives of Biochemistry and Biophysics 2004 425 2
    • Biosynthese von Naturstoffzuckern und enzymatische Glycodiversifizierung
      Christopher J. Thibodeaux, Charles E. Melançon, Hung-wen Liu
      Angewandte Chemie 2008 120 51
    • Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis
      Ute Galm, Ben Shen
      Expert Opinion on Drug Discovery 2006 1 5
    • The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis
      Jia Guo, Jinlei Zhao, Lili Li, Zhi Chen, Ying Wen, Jilun Li
      Molecular Genetics and Genomics 2010 283 2
    • A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases
      Laurenz Kellenberger, Ian S. Galloway, Guido Sauter, Günter Böhm, Ulf Hanefeld, Jesús Cortés, James Staunton, Peter F. Leadlay
      ChemBioChem 2008 9 16
    • Diversity of polyketide synthase gene sequences in Aspergillus species
      János Varga, Krisztina Rigó, Sándor Kocsubé, Balázs Farkas, Károly Pál
      Research in Microbiology 2003 154 8
    • Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum
      Christopher J Wilkinson, Elizabeth J Frost, James Staunton, Peter F Leadlay
      Chemistry & Biology 2001 8 12
    • Identification of a Methyltransferase fromMycobacterium smegmatisInvolved in Glycopeptidolipid Synthesis
      John H. Patterson, Malcolm J. McConville, Ruth E. Haites, Ross L. Coppel, Helen Billman-Jacobe
      Journal of Biological Chemistry 2000 275 32
    • Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans
      Sven-Eric Wohlert, Natalia Lomovskaya, Kerry Kulowski, Leonid Fonstein, James L Occi, Keith M Gewain, Douglas J MacNeil, C.Richard Hutchinson
      Chemistry & Biology 2001 8 7
    • Microbial metabolites: 45 years of wandering, wondering and discovering
      Satoshi Ōmura
      Tetrahedron 2011 67 35
    • Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains
      Lili Li, Jia Guo, Ying Wen, Zhi Chen, Yuan Song, Jilun Li
      Journal of Industrial Microbiology & Biotechnology 2010 37 7
    • Enhancement and selective production of avermectin B by recombinants of Streptomyces avermitilis via intraspecific protoplast fusion
      Zhi Chen, Jia Wen, Yuan Song, Ying Wen, JiLun Li
      Chinese Science Bulletin 2007 52 5
    • Spiroketal Formation and Modification in Avermectin Biosynthesis Involves a Dual Activity of AveC
      Peng Sun, Qunfei Zhao, Futao Yu, Hua Zhang, Zhuhua Wu, Yinyan Wang, Yan Wang, Qinglin Zhang, Wen Liu
      Journal of the American Chemical Society 2013 135 4
    • Synthetic Chain Terminators Off-Load Intermediates from a Type I Polyketide Synthase
      Manuela Tosin, Lorena Betancor, Elaine Stephens, W. M. Ariel Li, Jonathan B. Spencer, Peter F. Leadlay
      ChemBioChem 2010 11 4
    • A Novel Multidomain Polyketide Synthase Is Essential for Zeamine Production and the Virulence ofDickeya zeae
      Jianuan Zhou, Haibao Zhang, Jien Wu, Qiongguang Liu, Pinggen Xi, Jasmine Lee, Jinling Liao, Zide Jiang, Lian-Hui Zhang
      Molecular Plant-Microbe Interactions 2011 24 10
    • ExploitingStreptomyces coelicolorA3(2) P450s as a model for application in drug discovery
      David C Lamb, F Peter Guengerich, Steven L Kelly, Michael R Waterman
      Expert Opinion on Drug Metabolism & Toxicology 2006 2 1
    • Characterization of the Tautomycin Biosynthetic Gene Cluster fromStreptomyces spiroverticillatusUnveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis
      Wenli Li, Jianhua Ju, Scott R. Rajski, Hiroyuki Osada, Ben Shen
      Journal of Biological Chemistry 2008 283 42
    • Cloning and Characterization of the Biosynthetic Gene Cluster of 16-Membered Macrolide Antibiotic FD-891: Involvement of a Dual Functional Cytochrome P450 Monooxygenase Catalyzing Epoxidation and Hydroxylation
      Fumitaka Kudo, Atsushi Motegi, Kazutoshi Mizoue, Tadashi Eguchi
      ChemBioChem 2010 11 11
    • Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates
      Leonard Katz
      2009 459
    • Estimating polyketide metabolic potential among nonsporulating fungal endophytes of Vaccinium macrocarpon
      Michelle Sauer, Ping Lu, Rajinder Sangari, Sarah Kennedy, Jon Polishook, Gerald Bills, Zhiqiang An
      Mycological Research 2002 106 4
    • Modification of glycopeptidolipids by an O-methyltransferase of Mycobacterium smegmatis a
      Malcolm J. McConville, Dharshini Jeevarajah, Helen Billman-Jacobe, John H. Patterson
      Microbiology 2002 148 10
    • Multifactorial Control of Iteration Events in a Modular Polyketide Assembly Line
      Benjamin Busch, Nico Ueberschaar, Swantje Behnken, Yuki Sugimoto, Martina Werneburg, Nelly Traitcheva, Jing He, Christian Hertweck
      Angewandte Chemie International Edition 2013 52 20
    • A procedure for the metagenomics exploration of disease-suppressive soils
      J.D. van Elsas, A.J. Speksnijder, L.S. van Overbeek
      Journal of Microbiological Methods 2008 75 3
    • Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165
      Lei Chen, Yinhua Lu, Jun Chen, Weiwen Zhang, Dan Shu, Zhongjun Qin, Sheng Yang, Weihong Jiang
      Applied Microbiology and Biotechnology 2008 80 2
    • Production of Branched-Chain Alkylprodiginines in S. coelicolor by Replacement of the 3-Ketoacyl ACP Synthase III Initiation Enzyme, RedP
      SangJoon Mo, Beom Seok Kim, Kevin A. Reynolds
      Chemistry & Biology 2005 12 2
    • Surugamides A–E, Cyclic Octapeptides with Four d-Amino Acid Residues, from a Marine Streptomyces sp.: LC–MS-Aided Inspection of Partial Hydrolysates for the Distinction of d- and l-Amino Acid Residues in the Sequence
      Kentaro Takada, Akihiro Ninomiya, Masato Naruse, Yi Sun, Masayuki Miyazaki, Yuichi Nogi, Shigeru Okada, Shigeki Matsunaga
      The Journal of Organic Chemistry 2013 78 13
    • The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis
      K. T. Miyamoto, S. Kitani, M. Komatsu, H. Ikeda, T. Nihira
      Microbiology 2011 157 8
    • Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2)
      L. Lei, M. R. Waterman, A. J. Fulco, S. L. Kelly, D. C. Lamb
      Proceedings of the National Academy of Sciences 2004 101 2
    • Engineering theaveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced inStreptomyces avermitilis
      Kim Stutzman-Engwall, Steve Conlon, Ronald Fedechko, Frank Kaczmarek, Hamish McArthur, Anke Krebber, Yan Chen, Jeremy Minshull, Sun Ai Raillard, Claes Gustafsson
      Biotechnology and Bioengineering 2003 82 3
    • Recent developments in the area of macrolide antibiotics
      Takushi Kaneko, Hamish McArthur, Joyce Sutcliffe
      Expert Opinion on Therapeutic Patents 2000 10 4
    • Structural and Catalytic Diversity in the Two Family 11 Aldo-keto Reductases
      Andreas H. Ehrensberger, David K. Wilson
      Journal of Molecular Biology 2004 337 3
    • Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis
      Xiaolin Zhang, Zhi Chen, Meng Li, Ying Wen, Yuan Song, Jilun Li
      Applied Microbiology and Biotechnology 2006 72 5
    • Production of doramectin by rational engineering of the avermectin biosynthetic pathway
      Jian-Bo Wang, Hai-Xue Pan, Gong-Li Tang
      Bioorganic & Medicinal Chemistry Letters 2011 21 11
    • Synthetic biology of avermectin for production improvement and structure diversification
      Ying Zhuo, Tao Zhang, Qi Wang, Pablo Cruz-Morales, Buchang Zhang, Mei Liu, Francisco Barona-Gómez, Lixin Zhang
      Biotechnology Journal 2014 9 3
    • An adpA homologue in Streptomyces avermitilis is involved in regulation of morphogenesis and melanogenesis
      JinLei Zhao, Ying Wen, Zhi Chen, Yuan Song, JiLun Li
      Chinese Science Bulletin 2007 52 5
    • Analysis of neutral lipid biosynthesis in Streptomyces avermitilis MA-4680 and characterization of an acyltransferase involved herein
      Chlud Kaddor, Karolin Biermann, Rainer Kalscheuer, Alexander Steinbüchel
      Applied Microbiology and Biotechnology 2009 84 1
    • Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699
      Jun Xu, Taifo Mahmud, Heinz G Floss
      Archives of Biochemistry and Biophysics 2003 411 2
    • A Novel TetR Family Transcriptional Regulator, SAV576, Negatively Controls Avermectin Biosynthesis in Streptomyces avermitilis
      Jia Guo, Xuan Zhang, Shuai Luo, Fei He, Zhi Chen, Ying Wen, Jilun Li, Eric Cascales
      PLoS ONE 2013 8 8
    • A Splendid Gift from the Earth: The Origins and Impact of the Avermectins (Nobel Lecture)
      Satoshi Ōmura
      Angewandte Chemie International Edition 2016 55 35
    • A novel macrocyclic lactone with insecticidal bioactivity from Streptomyces microflavus neau3
      Xiang-Jing Wang, Ji Zhang, Chong-Xi Liu, Dian-Liang Gong, Hui Zhang, Ji-Dong Wang, Yi-Jun Yan, Wen-Sheng Xiang
      Bioorganic & Medicinal Chemistry Letters 2011 21 18
    • Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis
      Fei He, Wenshuai Liu, Di Sun, Shuai Luo, Zhi Chen, Ying Wen, Jilun Li
      Applied Microbiology and Biotechnology 2014 98 1
    • Impact of Some Avermectins on Lactoperoxidase in Bovine Milk
      Zeynep Köksal, Ramazan Kalın, İlhami Gülçin, Hasan Özdemir, Ali Atasever
      International Journal of Food Properties 2016 19 6
    • Isolation of High Molecular Weight DNA from Marine Sponge Bacteria for BAC Library Construction
      Yongchang Ouyang, Shikun Dai, Lianwu Xie, M. S. Ravi Kumar, Wei Sun, Huimin Sun, Danling Tang, Xiang Li
      Marine Biotechnology 2010 12 3
    • MapsiDB: an integrated web database for type I polyketide synthases
      Hongseok Tae, Jae Kyung Sohng, Kiejung Park
      Bioprocess and Biosystems Engineering 2009 32 6
    • Protein Engineering
      Pawan Kumar, Chaitan Khosla, Yi Tang
      2004 388
    • Sagittamides A and B. Polyacetoxy Long-Chain Acyl Amino Acids from a Didemnid Ascidian
      Sarah C. Lievens, Tadeusz F. Molinski
      Organic Letters 2005 7 11
    • The Complete Biosynthetic Gene Cluster of the 28-Membered Polyketide Macrolactones, Halstoctacosanolides, from Streptomyces halstedii HC34
      Shigehiro Tohyama, Katsumi Kakinuma, Tadashi Eguchi
      The Journal of Antibiotics 2006 59 1
    • Analysis of the enzymatic domains in the modular portion of the coronafacic acid polyketide synthase
      Sao Jiralerspong, Vidhya Rangaswamy, Carol L. Bender, Ronald J. Parry
      Gene 2001 270 1-2
    • Cyclization of polyketides and non-ribosomal peptides on and off their assembly lines
      Bo Pang, Min Wang, Wen Liu
      Natural Product Reports 2016 33 2
    • Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis
      Meng Li, Zhi Chen, Xiuping Lin, Xuan Zhang, Yuan Song, Ying Wen, Jilun Li
      Bioorganic & Medicinal Chemistry Letters 2008 18 20
    • Incomplete β-Ketone Processing as a Mechanism for Polyene Structural Variation in the FR-008/Candicidin Complex
      Yongjun Zhou, Jialiang Li, Jing Zhu, Shi Chen, Linquan Bai, Xiufen Zhou, Houming Wu, Zixin Deng
      Chemistry & Biology 2008 15 6
    • Isolation of soluble proteins from an industrial strain Streptomyces avermitilis in complex culture medium for two-dimensional gel electrophoresis
      Peng Yin, Yong-Hong Wang, Si-Liang Zhang, Ju Chu, Ying-Ping Zhuang, Mei-Long Wang, Jin Zhou
      Journal of Microbiological Methods 2008 73 2
    • A retinoic acid binding cytochrome P450: CYP120A1 from Synechocystis sp. PCC 6803
      Na Ke, Jerome Baudry, Thomas M. Makris, Mary A. Schuler, Stephen G. Sligar
      Archives of Biochemistry and Biophysics 2005 436 1
    • Biosynthesis of mercapturic acid derivative of the labdane-type diterpene, cyslabdan that potentiates imipenem activity against methicillin-resistant Staphylococcus aureus: cyslabdan is generated by mycothiol-mediated xenobiotic detoxification
      Haruo Ikeda, Kazuo Shin-ya, Tohru Nagamitsu, Hiroshi Tomoda
      Journal of Industrial Microbiology & Biotechnology 2016 43 2-3
    • Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain
      Jian-Bo Wang, Feng Zhang, Jin-Yue Pu, Juan Zhao, Qun-Fei Zhao, Gong-Li Tang
      Biotechnology Letters 2014 36 4
    • Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis
      Lijiang Song, Luisa Laureti, Christophe Corre, Pierre Leblond, Bertrand Aigle, Gregory L Challis
      The Journal of Antibiotics 2014 67 1
    • Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A
      Songhee Han, Tan-Viet Pham, Joo-Hwan Kim, Young-Ran Lim, Hyoung-Goo Park, Gun-Su Cha, Chul-Ho Yun, Young-Jin Chun, Lin-Woo Kang, Donghak Kim
      Archives of Biochemistry and Biophysics 2015 575
    • Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria
      Melinda L. Micallef, Paul M. D’Agostino, Deepti Sharma, Rajesh Viswanathan, Michelle C. Moffitt
      BMC Genomics 2015 16 1
    • Investigation of cytochromes P450 in myxobacteria: Excavation of cytochromes P450 from the genome ofSorangium cellulosumSo ce56
      Yogan Khatri, Frank Hannemann, Olena Perlova, Rolf Müller, Rita Bernhardt
      FEBS Letters 2011 585 11
    • The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines
      Adrian T. Keatinge-Clay
      Chemical Reviews 2017 117 8
    • Biosynthetic Origin of the Ether Ring in Platensimycin
      Jeffrey D. Rudolf, Liao-Bin Dong, Karina Manoogian, Ben Shen
      Journal of the American Chemical Society 2016 138 51
    • Insights into polyketide biosynthesis gained from repurposing antibiotic-producing polyketide synthases to produce fuels and chemicals
      Satoshi Yuzawa, Jay D Keasling, Leonard Katz
      The Journal of Antibiotics 2016 69 7
    • Multifactorial Control of Iteration Events in a Modular Polyketide Assembly Line
      Benjamin Busch, Nico Ueberschaar, Swantje Behnken, Yuki Sugimoto, Martina Werneburg, Nelly Traitcheva, Jing He, Christian Hertweck
      Angewandte Chemie 2013 125 20
    • Analysis of a Parallel Branch in the Mitomycin Biosynthetic Pathway Involving themitN-Encoded AziridineN-Methyltransferase
      Namthip Sitachitta, Nicole B. Lopanik, Yingqing Mao, David H. Sherman
      Journal of Biological Chemistry 2007 282 29
    • Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production
      Peng Yin, You-Yuan Li, Jin Zhou, Yong-Hong Wang, Si-Liang Zhang, Bang-Ce Ye, Wei-Feng Ge, Yue-Lan Xia
      Journal of Proteomics 2013 79
    • Identification and Analysis of the Paulomycin Biosynthetic Gene Cluster and Titer Improvement of the Paulomycins in Streptomyces paulus NRRL 8115
      Jine Li, Zhoujie Xie, Min Wang, Guomin Ai, Yihua Chen, Marie-Joelle Virolle
      PLOS ONE 2015 10 3
    • Leucanicidin and Endophenasides Result from Methyl-Rhamnosylation by the Same Tailoring Enzymes in Kitasatospora sp. MBT66
      Changsheng Wu, Marnix H. Medema, Rianne M. Läkamp, Le Zhang, Pieter C. Dorrestein, Young Hae Choi, Gilles P. van Wezel
      ACS Chemical Biology 2016 11 2
    • Multiple regulatory genes in the salinomycin biosynthetic gene cluster ofStreptomyces albus CCM 4719
      R. Knirschová, R. Nováková, L. Fecková, J. Timko, J. Turňa, J. Bistáková, J. Kormanec
      Folia Microbiologica 2007 52 4
    • Effect of Stereochemistry of Avermectin-Like 6,6-Spiroketals on Biological Activities and Endogenous Biotransformations inStreptomyces avermectinius
      Peng Sun, Qunfei Zhao, Hua Zhang, Jiequn Wu, Wen Liu
      ChemBioChem 2014 15 5
    • The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis
      Renjun Yang, Xingchao Liu, Ying Wen, Yuan Song, Zhi Chen, Jilun Li
      Applied Microbiology and Biotechnology 2015 99 24
    • fabC of Streptomyces lydicus involvement in the biosynthesis of streptolydigin
      Guang-Rong Zhao, Ting Luo, Yong-Jin Zhou, Xin Jiang, Bin Qiao, Feng-Ming Yu, Ying-Jin Yuan
      Applied Microbiology and Biotechnology 2009 83 2
    • Biosynthetic engineering of polyketide synthases
      Barrie Wilkinson, Steven G Kendrew, Rose M Sheridan, Peter F Leadlay
      Expert Opinion on Therapeutic Patents 2003 13 10
    • Genetic engineering of Streptomyces bingchenggensis to produce milbemycins A3/A4 as main components and eliminate the biosynthesis of nanchangmycin
      Ji Zhang, Jing An, Ji-Jia Wang, Yi-Jun Yan, Hai-Rong He, Xiang-Jing Wang, Wen-Sheng Xiang
      Applied Microbiology and Biotechnology 2013 97 23
    • Recent Developments in the Production of Novel Polyketides by Combinatorial Biosynthesis
      T. Ashton Cropp, Beom S. Kim, Brian J. Beck, Yeo Joon Yoon, David H. Sherman, Kevin A. Reynolds
      Biotechnology and Genetic Engineering Reviews 2002 19 1
    • Streptomyces autolyticus JX-47 Large-Insert Bacterial Artificial Chromosome Library Construction and Identification of Clones Covering Geldanamycin Biosynthesis Gene Cluster
      Shikun Dai, Yongchang Ouyang, Guanghua Wang, Xiang Li
      Current Microbiology 2011 63 1
    • Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue
      Molecules and Cells 2016 39 3
    • Targeting polyketide synthase gene pool within actinomycetes: new degenerate primers
      Miloje Savic, Branka Vasiljevic
      Journal of Industrial Microbiology & Biotechnology 2006 33 6
    • The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis
      Juan F Martín, Antonio Rodríguez-García, Paloma Liras
      The Journal of Antibiotics 2017 70 5
    • Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis
      Suandi Pratama Sultan, Shigeru Kitani, Kiyoko T Miyamoto, Hiroyuki Iguchi, Tokitaka Atago, Haruo Ikeda, Takuya Nihira
      Applied Microbiology and Biotechnology 2016 100 22
    • Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin
      Satoshi Yuzawa, Clara H Eng, Leonard Katz, Jay D Keasling
      The Journal of Antibiotics 2014 67 2
    • Genomic Enzymology: Web Tools for Leveraging Protein Family Sequence–Function Space and Genome Context to Discover Novel Functions
      John A. Gerlt
      Biochemistry 2017 56 33
    • Natural products discovery from micro-organisms in the post-genome era
      Haruo Ikeda
      Bioscience, Biotechnology, and Biochemistry 2017 81 1
    • Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges
      Satoshi Yuzawa, Jay D Keasling, Leonard Katz
      The Journal of Antibiotics 2017 70 4
    • Characterization and analysis of an industrial strain of Streptomyces bingchenggensis by genome sequencing and gene microarray
      Xiang-Jing Wang, Bo Zhang, Yi-Jun Yan, Jing An, Ji Zhang, Chong-Xi Liu, Wen-Sheng Xiang, J.B. Bell
      Genome 2013 56 11
    • Cloning, Sequencing, and Functional Analysis of the Biosynthetic Gene Cluster of Macrolactam Antibiotic Vicenistatin in Streptomyces halstedii
      Yasushi Ogasawara, Kinya Katayama, Atsushi Minami, Miyuki Otsuka, Tadashi Eguchi, Katsumi Kakinuma
      Chemistry & Biology 2004 11 1
    • Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis
      Myoun-Su Kim, Wan-Je Cho, Myoung Chong Song, Seong-Whan Park, Kaeun Kim, Eunji Kim, Naryeong Lee, Sang-Jip Nam, Ki-Hoon Oh, Yeo Joon Yoon
      Microbial Cell Factories 2017 16 1
    • Mutasynthesis of pyrrole spiroketal compound using calcimycin 3-hydroxy anthranilic acid biosynthetic mutant
      Lixia Gou, Qiulin Wu, Shuangjun Lin, Xiangmei Li, Jingdan Liang, Xiufen Zhou, Derong An, Zixin Deng, Zhijun Wang
      Applied Microbiology and Biotechnology 2013 97 18
    • Probing Intra- versus Interchain Kinetic Preferences of L-Thr Acylation on Dimeric VibF with Mass Spectrometry
      Leslie M. Hicks, Carl J. Balibar, Christopher T. Walsh, Neil L. Kelleher, Nathan J. Hillson
      Biophysical Journal 2006 91 7
    • Production of 4′-epidaunorubicin by metabolic engineering of Streptomyces coeruleorubidus strain SIPI-1482
      Ke Shang, Youjia Hu, Chunbao Zhu, Baoquan Zhu
      World Journal of Microbiology and Biotechnology 2008 24 7
    • Raising the avermectins production in Streptomyces avermitilis by utilizing nanosecond pulsed electric fields (nsPEFs)
      Jinsong Guo, Ruonan Ma, Bo Su, Yinglong Li, Jue Zhang, Jing Fang
      Scientific Reports 2016 6 1
    • A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit
      Meredith A. Skiba, Andrew P. Sikkema, Nathan A. Moss, Collin L. Tran, Rebecca M. Sturgis, Lena Gerwick, William H. Gerwick, David H. Sherman, Janet L. Smith
      ACS Chemical Biology 2017 12 12
    • Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms
      Ayako Nara, Takuya Hashimoto, Mamoru Komatsu, Makoto Nishiyama, Tomohisa Kuzuyama, Haruo Ikeda
      The Journal of Antibiotics 2017 70 5
    • Engineered polyketides: Synergy between protein and host level engineering
      Jesus F. Barajas, Jacquelyn M. Blake-Hedges, Constance B. Bailey, Samuel Curran, Jay. D. Keasling
      Synthetic and Systems Biotechnology 2017 2 3
    • Enhanced validamycin production and gene expression at elevated temperature in Streptomyces hygroscopicus subsp. jingangensis 5008
      Lei Li, LinQuan Bai, XiuFen Zhou, ZiXin Deng
      Science Bulletin 2009 54 7
    • A novel regio-specific cyclosporin hydroxylase gene revealed through the genome mining of Pseudonocardia autotrophica
      Jun-Gyu Ban, Min-Woo Woo, Bo-Ram Lee, Mi-Jin Lee, Si-Sun Choi, Eung-Soo Kim
      Journal of Industrial Microbiology & Biotechnology 2014 41 5
    • AFEAP cloning: a precise and efficient method for large DNA sequence assembly
      Fanli Zeng, Jinping Zang, Suhua Zhang, Zhimin Hao, Jingao Dong, Yibin Lin
      BMC Biotechnology 2017 17 1
    • Comprehensive Natural Products II
      Alison M. Hill, James Staunton
      2010
    • Crystallographic analysis of a novel aldo-keto reductase fromThermotoga maritimain complex with NADP+
      Hai Hou, Ruiying Li, Xiaoyan Wang, Zhen Yuan, Xuemeng Liu, Zhenmin Chen, Xiaoling Xu
      Acta Crystallographica Section F Structural Biology Communications 2015 71 7
    • Ein vortreffliches Geschenk der Erde: Ursprünge und Auswirkungen der Avermectine (Nobel-Aufsatz)
      Satoshi Ōmura
      Angewandte Chemie 2016 128 35
    • Enhanced production of hydroxylated macrolides from the pikromycin pathway of Streptomyces venezuelae
      Sang Kil Lee, Jay Sung Joong Hong, Cha Yong Choi, Jong Seog Ahn, Yeo Joon Yoon
      Enzyme and Microbial Technology 2006 39 4
    • Improvement of transformation and electroduction in avermectin high-producer,Streptomyces avermitilis
      Wei Gong, Weihong Jiang, Yunliu Yang, Juishen Chiao
      Folia Microbiologica 2004 49 4
    • In vivo investigation of the substrate recognition capability and activity affecting amino acid residues of glycosyltransferase FscMI in the biosynthesis of candicidin
      Xuan Lei, Lingxin Kong, Chen Zhang, Qian Liu, Fen Yao, Weike Zhang, Zixin Deng, Delin You
      Molecular BioSystems 2013 9 3
    • Interrogation of Streptomyces avermitilis for efficient production of avermectins
      Jinsong Chen, Mei Liu, Xueting Liu, Jin Miao, Chengzhang Fu, Heyong Gao, Rolf Müller, Qing Zhang, Lixin Zhang
      Synthetic and Systems Biotechnology 2016 1 1
    • Semi-rational engineering of a thermostable aldo–keto reductase from Thermotoga maritima for synthesis of enantiopure ethyl-2-hydroxy-4-phenylbutyrate (EHPB)
      Zhiguo Wang, Shuo Zhou, Shuangling Zhang, Sa Zhang, Fangmeng Zhu, Xiaolu Jin, Zhenming Chen, Xiaoling Xu
      Scientific Reports 2017 7 1
    • Synthetic biology of polyketide synthases
      Satoshi Yuzawa, Tyler W. H. Backman, Jay D. Keasling, Leonard Katz
      Journal of Industrial Microbiology & Biotechnology 2018
    • Haruo IKEDA
      Kagaku To Seibutsu 2015 54 1
    • Biosynthesis of the Antitumor Chromomycin A3 in Streptomyces griseus
      Nuria Menéndez, Mohammad Nur-e-Alam, Alfredo F. Braña, Jürgen Rohr, José A. Salas, Carmen Méndez
      Chemistry & Biology 2004 11 1
    • Carbohydrate-Modifying Biocatalysts
      Marta Luzhetska, Andreas Bechthold
      2011
    • Comprehensive Natural Products II
      Christophe Corre, Gregory L. Challis
      2010
    • Deletion analysis of oligomycin PKS genes (olmA) inStreptomyces avermitilis
      Xiaolin Zhang, Zhi Chen, Jinlei Zhao, Yuan Song, Ying Wen, Jilun Li
      Chinese Science Bulletin 2004 49 4
    • Discovery of Splendid Gift, Avermectin, and Studies on Avermectin Biosynthesis
      Haruo IKEDA
      TRENDS IN THE SCIENCES 2016 21 2
    • Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5
      Ivy Grace Umadhay Pait, Shigeru Kitani, Farah Wahidah Roslan, Dana Ulanova, Masayoshi Arai, Haruo Ikeda, Takuya Nihira
      Journal of Industrial Microbiology & Biotechnology 2018 45 2
    • Editorial: On artemisinin, avermectins and Nobel Prizes
      Rich Boden
      FEMS Microbiology Letters 2015 362 23
    • Encyclopedia of Signaling Molecules
      Kirsty J. McLean, Andrew W. Munro
      2016
    • Encyclopedia of Signaling Molecules
      Kirsty J. McLean, Andrew W. Munro
      2018
    • Enzyme Technologies
      Lishan Zhao, Hung-Wen Liu
      2011
    • Genome-guided exploration of metabolic features of Streptomyces peucetius ATCC 27952: past, current, and prospect
      Nguyen Huy Thuan, Dipesh Dhakal, Anaya Raj Pokhrel, Luan Luong Chu, Thi Thuy Van Pham, Anil Shrestha, Jae Kyung Sohng
      Applied Microbiology and Biotechnology 2018
    • Handbook of Green Chemistry
      Junhua Tao, Alex Chu
      2012
    • Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers
      Qian Deng, Li Zhou, Meizhong Luo, Zixin Deng, Changming Zhao
      Synthetic and Systems Biotechnology 2017 2 1
    • Macrolide Antibiotics
      Haruo Ikeda, Satoshi Òmura
      2003
    • Mutation breeding of high avermectin B1a-producing strain by the combination of high energy carbon heavy ion irradiation and sodium nitrite mutagenesis based on high throughput screening
      Xiaoqing Song, Yun Zhang, Xudong Zhu, Yonghong Wang, Ju Chu, Yingping Zhuang
      Biotechnology and Bioprocess Engineering 2017 22 5
    • New and Future Developments in Microbial Biotechnology and Bioengineering
      Aleem B. Pinjari, Pallaval Veera Bramhachari
      2018
    • Novel Antimicrobial Agents and Strategies
      Hiroki Ando, Robert Citorik, Sara Cleto, Sebastien Lemire, Mark Mimee, Timothy Lu
      2014
    • Organic Chemistry - Breakthroughs and Perspectives
      Michael J. Smanski, Xu-Dong Qu, Wen Liu, Ben Shen, Yi Tang, Yi Yu, Zi-Xin Deng
      2012
    • Toxins and Biologically Active Compounds from Microalgae, Volume 1
      Kinya Hotta, Kenji Watanabe
      2014
    • Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism
      Anja Greule, Jeanette E. Stok, James J. De Voss, Max J. Cryle
      Natural Product Reports 2018

    Online Impact

    Article usage

    Article usage: August 1999 to April 2018

    AbstractFullPdf
    Aug 19997788133
    Sep 1999104249
    Oct 1999162426
    Nov 199962322
    Dec 199963222
    Total 1999115209252
    Jan 200022012
    Feb 200032538
    Mar 200011219
    Apr 200032415
    May 200023038
    Jun 200001722
    Jul 200062014
    Aug 200011421
    Sep 200021722
    Oct 200032718
    Nov 200001745
    Dec 200031812
    Total 200026241276
    Jan 200153331
    Feb 200102219
    Mar 200121414
    Apr 200132244
    May 200113224
    Jun 200101425
    Jul 200152314
    Aug 200152527
    Sep 200162229
    Oct 200144530
    Nov 200174033
    Dec 200132724
    Total 200141319314
    Jan 200223646
    Feb 200253118
    Mar 200263827
    Apr 200241930
    May 200261822
    Jun 2002133822
    Jul 200234626
    Aug 200213620
    Sep 200294131
    Oct 2002113437
    Nov 200222424
    Dec 200243430
    Total 200266395333
    Jan 200312321
    Feb 200345138
    Mar 200328426
    Apr 2003820945
    May 2003410446
    Jun 2003311438
    Jul 20031611232
    Aug 20031710131
    Sep 20033111257
    Oct 2003219233
    Nov 20031713634
    Dec 20031511436
    Total 20031391252437
    Jan 2004199022
    Feb 20041912422
    Mar 20041417236
    Apr 20042716341
    May 20041516840
    Jun 20041815243
    Jul 20042815637
    Aug 20041714634
    Sep 20042212132
    Oct 20042211631
    Nov 20041713314
    Dec 20041710125
    Total 20042351642377
    Jan 20051311435
    Feb 200578117
    Mar 20052011130
    Apr 20052010434
    May 2005177921
    Jun 2005129229
    Jul 2005128428
    Aug 2005127824
    Sep 2005147936
    Oct 2005198231
    Nov 20052411432
    Dec 2005279541
    Total 20051971113358
    Jan 20061211233
    Feb 20062110825
    Mar 20062510622
    Apr 20061710025
    May 2006328226
    Jun 2006167320
    Jul 2006166718
    Aug 2006126317
    Sep 2006249538
    Oct 20061013738
    Nov 2006258742
    Dec 2006126221
    Total 20062221092325
    Jan 2007197940
    Feb 2007187130
    Mar 2007157722
    Apr 2007119716
    May 2007168133
    Jun 2007126519
    Jul 200764021
    Aug 200775828
    Sep 200797124
    Oct 2007177125
    Nov 2007128227
    Dec 2007166022
    Total 2007158852307
    Jan 2008136425
    Feb 200885419
    Mar 2008213329
    Apr 200866115
    May 2008176128
    Jun 2008189721
    Jul 2008265019
    Aug 2008153311
    Sep 2008425722
    Oct 2008377125
    Nov 2008376127
    Dec 2008253615
    Total 2008265678256
    Jan 2009355122
    Feb 2009324328
    Mar 2009205021
    Apr 2009206115
    May 2009173721
    Jun 200986815
    Jul 2009346622
    Aug 2009295129
    Sep 2009344731
    Oct 2009286719
    Nov 2009125716
    Dec 2009206822
    Total 2009289666261
    Jan 2010105522
    Feb 2010174718
    Mar 2010257129
    Apr 2010175016
    May 2010158019
    Jun 2010134218
    Jul 2010205720
    Aug 201064713
    Sep 2010235817
    Oct 2010294228
    Nov 2010256819
    Dec 2010134312
    Total 2010213660231
    Jan 2011245417
    Feb 201174018
    Mar 2011257525
    Apr 2011206017
    May 2011284421
    Jun 2011265222
    Jul 2011214118
    Aug 2011314126
    Sep 2011264621
    Oct 2011318723
    Nov 2011216723
    Dec 2011204222
    Total 2011280649253
    Jan 2012174015
    Feb 2012194624
    Mar 2012303921
    Apr 2012185116
    May 2012288528
    Jun 2012264425
    Jul 2012205227
    Aug 2012114218
    Sep 2012132714
    Oct 2012135616
    Nov 2012134620
    Dec 2012175116
    Total 2012225579240
    Jan 2013205024
    Feb 2013213823
    Mar 2013274730
    Apr 2013215125
    May 2013285633
    Jun 2013253115
    Jul 2013143614
    Aug 2013282325
    Sep 2013293431
    Oct 2013254333
    Nov 2013253332
    Dec 2013242821
    Total 2013287470306
    Jan 2014173116
    Feb 2014163617
    Mar 2014405225
    Apr 2014317120
    May 2014283527
    Jun 2014283821
    Jul 2014294225
    Aug 2014214118
    Sep 2014204824
    Oct 2014245918
    Nov 2014196426
    Dec 2014322917
    Total 2014305546254
    Jan 2015233118
    Feb 2015132512
    Mar 2015154811
    Apr 2015274034
    May 2015162616
    Jun 2015253921
    Jul 2015144026
    Aug 201572532
    Sep 2015252116
    Oct 201597136109
    Nov 2015768053
    Dec 2015524839
    Total 2015390559387
    Jan 2016368834
    Feb 2016303036
    Mar 2016263527
    Apr 2016325040
    May 2016424137
    Jun 2016234029
    Jul 2016292625
    Aug 2016313826
    Sep 2016193221
    Oct 2016294331
    Nov 2016223526
    Dec 2016172831
    Total 2016336486363
    Jan 2017223714
    Feb 2017354129
    Mar 2017302626
    Apr 2017352815
    May 2017212814
    Jun 2017242216
    Jul 2017243716
    Aug 2017251820
    Sep 2017324122
    Oct 2017194524
    Nov 2017195219
    Dec 201713238
    Total 2017299398223
    Jan 2018334027
    Feb 2018274110
    Mar 2018545431
    Apr 2018526324
    Total 201816619892
    Total4254130045845
    PreviousNext
    Back to top
    Article Alerts
    Email Article

    Thank you for your interest in spreading the word on PNAS.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
    (Your Name) has sent you a message from PNAS
    (Your Name) thought you would like to see the PNAS web site.
    Citation Tools
    Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
    Haruo Ikeda, Tomoko Nonomiya, Masayo Usami, Toshio Ohta, Satoshi Ōmura
    Proceedings of the National Academy of Sciences Aug 1999, 96 (17) 9509-9514; DOI: 10.1073/pnas.96.17.9509

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Request Permissions
    Share
    Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
    Haruo Ikeda, Tomoko Nonomiya, Masayo Usami, Toshio Ohta, Satoshi Ōmura
    Proceedings of the National Academy of Sciences Aug 1999, 96 (17) 9509-9514; DOI: 10.1073/pnas.96.17.9509
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like
    • Mendeley logo Mendeley

    More Articles of This Classification

    Biological Sciences

    • COBLL1 modulates cell morphology and facilitates androgen receptor genomic binding in advanced prostate cancer
    • Coupling MALDI-TOF mass spectrometry protein and specialized metabolite analyses to rapidly discriminate bacterial function
    • Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline
    Show more

    Biochemistry

    • Reactivity of O2 versus H2O2 with polysaccharide monooxygenases
    • Complementary charge-based interaction between the ribosomal-stalk protein L7/12 and IF2 is the key to rapid subunit association
    • Enzymatic control of dioxygen binding and functionalization of the flavin cofactor
    Show more

    Related Content

    • No related articles found.
    • Scopus
    • PubMed
    • Google Scholar

    Cited by...

    • SdrA, a New DeoR Family Regulator Involved in Streptomyces avermitilis Morphological Development and Antibiotic Production
    • Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules
    • Characterization of SAV7471, a TetR-Family Transcriptional Regulator Involved in the Regulation of Coenzyme A Metabolism in Streptomyces avermitilis
    • Post-PKS Tailoring Steps of the Spiramycin Macrolactone Ring in Streptomyces ambofaciens
    • Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?
    • Characterization of the Biosynthesis Gene Cluster for the Pyrrole Polyether Antibiotic Calcimycin (A23187) in Streptomyces chartreusis NRRL 3882
    • Genome Sequence of the Milbemycin-Producing Bacterium Streptomyces bingchenggensis
    • Cloning of Separate Meilingmycin Biosynthesis Gene Clusters by Use of Acyltransferase-Ketoreductase Didomain PCR Amplification
    • Characterization of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis
    • Evolution of polyketide synthases in bacteria
    • Analysis of a Parallel Branch in the Mitomycin Biosynthetic Pathway Involving the mitN-Encoded Aziridine N-Methyltransferase
    • Biosynthetic Gene Cluster for the Polyenoyltetramic Acid {alpha}-Lipomycin
    • Analysis of the Loading and Hydroxylation Steps in Lankamycin Biosynthesis in Streptomyces rochei
    • Characterization of the Nodularin Synthetase Gene Cluster and Proposed Theory of the Evolution of Cyanobacterial Hepatotoxins
    • Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis of the Antitumor Chlorinated Polyenone Neocarzilin in "Streptomyces carzinostaticus"
    • Phylogenetic Analysis of Polyketide Synthase I Domains from Soil Metagenomic Libraries Allows Selection of Promising Clones
    • In Vivo Analysis of the Regulatory Genes in the Nystatin Biosynthetic Gene Cluster of Streptomyces noursei ATCC 11455 Reveals Their Differential Control Over Antibiotic Biosynthesis
    • Genes Coding for Hepatotoxic Heptapeptides (Microcystins) in the Cyanobacterium Anabaena Strain 90
    • Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2)
    • The 1.92-A Structure of Streptomyces coelicolor A3(2) CYP154C1: A NEW MONOOXYGENASE THAT FUNCTIONALIZES MACROLIDE RING SYSTEMS
    • Cloning and Analysis of a DNA Fragment Stimulating Avermectin Production in Various Streptomyces avermitilis Strains
    • Analysis of an 8.1-kb DNA Fragment Contiguous with the Erythromycin Gene Cluster of Saccharopolyspora erythraea in the eryCI-Flanking Region
    • Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
    • Functional Analysis of OleY L-Oleandrosyl 3-O-Methyltransferase of the Oleandomycin Biosynthetic Pathway in Streptomyces antibioticus
    • Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway of Streptomyces venezuelae
    • Engineered Fatty Acid Biosynthesis in Streptomyces by Altered Catalytic Function of {beta}-Ketoacyl-Acyl Carrier Protein Synthase III
    • Identification of a Methyltransferase from Mycobacterium smegmatis Involved in Glycopeptidolipid Synthesis
    • Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
    • Identification of a Methyltransferase from Mycobacterium smegmatis Involved in Glycopeptidolipid Synthesis
    • Scopus (246)
    • Google Scholar

    Similar Articles

    You May Also be Interested in

    Karina Guziewicz and Artur Cideciyan explain a potential gene therapy approach for macular degeneration.
    Gene therapy for retinal disease
    Karina Guziewicz and Artur Cideciyan explain a potential gene therapy approach for macular degeneration.
    Listen
    Past PodcastsSubscribe
    PNAS Profile of Alexander Rudensky, winner of the Vilcek Prize in Biomedical Science
    PNAS Profile
    PNAS Profile of Alexander Rudensky, winner of the Vilcek Prize in Biomedical Science
    Ambrosia beetles, which bore into host trees and cultivate fungi, select trees with elevated ethanol content because ethanol promotes growth of preferred fungal species.
    Fungus-farming beetles use alcohol to screen symbionts
    Ambrosia beetles, which bore into host trees and cultivate fungi, select trees with elevated ethanol content because ethanol promotes growth of preferred fungal species.
    Image courtesy of Gernot Kunz (Karl-Franzens-Universität Graz, Graz, Austria).
    A study examines the walking and climbing capabilities of human ancestors.
    Evolution of human locomotion
    A study examines the walking and climbing capabilities of human ancestors.
    Researchers have engineered the complete biosynthetic pathway for a potential cancer drug into a single yeast strain, paving the way toward the commercial brewing of medically important compounds.
    Brewer’s yeast engineered to produce potential cancer drug
    Researchers have engineered the complete biosynthetic pathway for a potential cancer drug into a single yeast strain, paving the way toward the commercial brewing of medically important compounds.
    Image courtesy of Pixabay/Republica.
    Proceedings of the National Academy of Sciences: 115 (16)
    Current Issue

    Submit

    Sign up for Article Alerts

    Jump to section

    • Article
      • Abstract
      • MATERIALS AND METHODS
      • RESULTS AND DISCUSSION
      • Acknowledgments
      • Footnotes
      • ABBREVIATIONS
      • References
    • Authors & Info
    • PDF
    Site Logo
    Powered by HighWire
    • Submit Manuscript
    • Twitter
    • Facebook
    • RSS Feeds
    • Email Alerts

    Articles

    • Current Issue
    • Latest Articles
    • Archive

    PNAS Portals

    • Classics
    • Front Matter
    • Teaching Resources
    • Anthropology
    • Chemistry
    • Physics
    • Sustainability Science

    Information for

    • Authors
    • Reviewers
    • Press

    Feedback    Privacy/Legal

    Copyright © 2018 National Academy of Sciences.