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↵1I.S.-Z., A.H.-M., and J.E.-G. contributed equally to this work.
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Communicated by Eric S. Lander, The Broad Institute, Cambridge, MA, March 23, 2009 (received for review March 23, 2008)
Abstract
Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study of genetic diversity and linkage disequilibrium structure of different populations has made it possible to develop tagging and imputation strategies to comprehensively analyze common genetic variation in association studies of complex diseases. We assessed the benefit of a Mexican haplotype map to improve identification of genes related to common diseases in the Mexican population. We evaluated genetic diversity, linkage disequilibrium patterns, and extent of haplotype sharing using genomewide data from Mexican Mestizos from regions with different histories of admixture and particular population dynamics. Ancestry was evaluated by including 1 Mexican Amerindian group and data from the HapMap. Our results provide evidence of genetic differences between Mexican subpopulations that should be considered in the design and analysis of association studies of complex diseases. In addition, these results support the notion that a haplotype map of the Mexican Mestizo population can reduce the number of tag SNPs required to characterize common genetic variation in this population. This is one of the first genomewide genotyping efforts of a recently admixed population in Latin America.
Footnotes
- 2To whom correspondence should be addressed. E-mail: gjimenez{at}inmegen.gob.mx
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Author contributions: I.S.-Z., A.H.-M., J.E.-G., C.L., and G.J.-S. designed research; I.S.-Z., A.H.-M., J.E.-G., L.U.-F., A.C., E.B.-O., L.d.B.-P., D.V.-F., C.L., E.B., S.M., and G.J.-S. performed research; J.E.-G. and C.D. contributed new reagents/analytic tools; I.S.-Z., A.H.-M., J.E.-G., J.C.F.-L., L.U.-F., R.G., E.H.-L., C.D., and G.J.-S. analyzed data; and I.S.-Z., A.H.-M., J.E.-G., and G.J.-S. wrote the paper.
The authors declare no conflict of interest.
Freely available online through the PNAS open access option.
Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico
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