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Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

Adeel Safdar, Jacqueline M. Bourgeois, Daniel I. Ogborn, Jonathan P. Little, Bart P. Hettinga, Mahmood Akhtar, James E. Thompson, Simon Melov, Nicholas J. Mocellin, Gregory C. Kujoth, Tomas A. Prolla and Mark A. Tarnopolsky
PNAS February 22, 2011. 201019581; published ahead of print February 22, 2011. https://doi.org/10.1073/pnas.1019581108
Adeel Safdar
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Jacqueline M. Bourgeois
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Daniel I. Ogborn
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Jonathan P. Little
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Bart P. Hettinga
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Mahmood Akhtar
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James E. Thompson
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Simon Melov
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Nicholas J. Mocellin
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  1. Edited* by Bruce M. Spiegelman, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA 02115, and approved January 28, 2011 (received for review December 30, 2010)

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Abstract

A causal role for mitochondrial DNA (mtDNA) mutagenesis in mammalian aging is supported by recent studies demonstrating that the mtDNA mutator mouse, harboring a defect in the proofreading-exonuclease activity of mitochondrial polymerase gamma, exhibits accelerated aging phenotypes characteristic of human aging, systemic mitochondrial dysfunction, multisystem pathology, and reduced lifespan. Epidemiologic studies in humans have demonstrated that endurance training reduces the risk of chronic diseases and extends life expectancy. Whether endurance exercise can attenuate the cumulative systemic decline observed in aging remains elusive. Here we show that 5 mo of endurance exercise induced systemic mitochondrial biogenesis, prevented mtDNA depletion and mutations, increased mitochondrial oxidative capacity and respiratory chain assembly, restored mitochondrial morphology, and blunted pathological levels of apoptosis in multiple tissues of mtDNA mutator mice. These adaptations conferred complete phenotypic protection, reduced multisystem pathology, and prevented premature mortality in these mice. The systemic mitochondrial rejuvenation through endurance exercise promises to be an effective therapeutic approach to mitigating mitochondrial dysfunction in aging and related comorbidities.

  • proliferator-activated receptor gamma coactivator-1α
  • sarcopenia
  • cardiac hypertrophy

Footnotes

  • Author contributions: A.S. and M.A.T. designed research; A.S., J.M.B., D.I.O., J.P.L., B.P.H., M.A., J.E.T., S.M., and N.J.M. performed research; J.E.T., S.M., G.C.K., T.A.P., and M.A.T. contributed new reagents/analytic tools; A.S., J.M.B., and B.P.H. analyzed data; and A.S. wrote the paper.

  • The authors declare no conflict of interest.

  • ↵*This Direct Submission article had a prearranged editor.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1019581108/-/DCSupplemental.

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Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice
Adeel Safdar, Jacqueline M. Bourgeois, Daniel I. Ogborn, Jonathan P. Little, Bart P. Hettinga, Mahmood Akhtar, James E. Thompson, Simon Melov, Nicholas J. Mocellin, Gregory C. Kujoth, Tomas A. Prolla, Mark A. Tarnopolsky
Proceedings of the National Academy of Sciences Feb 2011, 201019581; DOI: 10.1073/pnas.1019581108

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Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice
Adeel Safdar, Jacqueline M. Bourgeois, Daniel I. Ogborn, Jonathan P. Little, Bart P. Hettinga, Mahmood Akhtar, James E. Thompson, Simon Melov, Nicholas J. Mocellin, Gregory C. Kujoth, Tomas A. Prolla, Mark A. Tarnopolsky
Proceedings of the National Academy of Sciences Feb 2011, 201019581; DOI: 10.1073/pnas.1019581108
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  • Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise
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