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EDITORIAL

Stanley Falkow

"Statement on scientific publication and security" fails to provide necessary guidelines
PNAS 2003 100: 5575; published online before print May 12 2003, 10.1073/pnas.1232277100 [Extract] [Full Text] [PDF]  

COMMENTARIES

Nils Chr. Stenseth and Glenn-Peter Saetre

Sexual selection forms the structure and dynamics of ecological communities
PNAS 2003 100: 5576-5577; published online before print May 5 2003, 10.1073/pnas.1031800100 [Extract] [Full Text] [PDF]  
See companion article on page 5858

Richard L. Veech

A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis
PNAS 2003 100: 5578-5580; published online before print April 29 2003, 10.1073/pnas.1132039100 [Extract] [Full Text] [PDF]  
See companion article on page 5107 in issue 9 of volume 100

Richard G. Walker

More whistles and bells for fly hearing
PNAS 2003 100: 5581-5582; published online before print May 5 2003, 10.1073/pnas.1232224100 [Extract] [Full Text] [PDF]  
See companion article on page 5514 in issue 9 of volume 100

James P. Calvet

New insights into ciliary function: Kidney cysts and photoreceptors
PNAS 2003 100: 5583-5585; published online before print May 5 2003, 10.1073/pnas.1031799100 [Extract] [Full Text] [PDF]  
See companion article on page 5286 in issue 9 of volume 100

Suzanne Sandmeyer

Integration by design
PNAS 2003 100: 5586-5588; published online before print May 5 2003, 10.1073/pnas.1031802100 [Extract] [Full Text] [PDF]  
See companion article on page 5891

Yo Otsu and Timothy H. Murphy

Mind-altering miniature neurotransmitter release?
PNAS 2003 100: 5589-5590; published online before print May 5 2003, 10.1073/pnas.1131911100 [Extract] [Full Text] [PDF]  
See companion article on page 6139

PHYSICAL SCIENCES

Applied Mathematics

David L. Donoho and Carrie Grimes

Hessian eigenmaps: Locally linear embedding techniques for high-dimensional data
PNAS 2003 100: 5591-5596; published online before print April 30 2003, 10.1073/pnas.1031596100 [Abstract] [Full Text] [PDF]  

Applied Physical Sciences

Chemistry

Igor V. Rubtsov, Jianping Wang, and Robin M. Hochstrasser

Dual-frequency 2D-IR spectroscopy heterodyned photon echo of the peptide bond
PNAS 2003 100: 5601-5606; published online before print April 22 2003, 10.1073/pnas.0931292100 [Abstract] [Full Text] [PDF]  

Chetan Lad, Nicholas H. Williams, and Richard Wolfenden

The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases
PNAS 2003 100: 5607-5610; published online before print April 29 2003, 10.1073/pnas.0631607100 [Abstract] [Full Text] [PDF]  

Mathematics

Akos Dobay, Jacques Dubochet, Kenneth Millett, Pierre-Edouard Sottas, and Andrzej Stasiak

Scaling behavior of random knots
PNAS 2003 100: 5611-5615; published online before print April 29 2003, 10.1073/pnas.0330884100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Biochemistry

Chetan Lad, Nicholas H. Williams, and Richard Wolfenden

The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases
PNAS 2003 100: 5607-5610; published online before print April 29 2003, 10.1073/pnas.0631607100 [Abstract] [Full Text] [PDF]  

Eigo Suyama, Hiroaki Kawasaki, Motowo Nakajima, and Kazunari Taira

Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes
PNAS 2003 100: 5616-5621; published online before print April 28 2003, 10.1073/pnas.1035850100 [Abstract] [Full Text] [PDF]  

Kazuya Ueda, Gregory M. Lipkind, An Zhou, Xiaorong Zhu, Andrey Kuznetsov, Louis Philipson, Paul Gardner, Chunling Zhang, and Donald F. Steiner

Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1)
PNAS 2003 100: 5622-5627; published online before print April 29 2003, 10.1073/pnas.0631617100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Su Gao and M. Daniel Lane

Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem
PNAS 2003 100: 5628-5633; published online before print April 30 2003, 10.1073/pnas.1031698100 [Abstract] [Full Text] [PDF]  

Yasuyuki Irie, Makio Saeki, Yoshinori Kamisaki, Emil Martin, and Ferid Murad

Histone H1.2 is a substrate for denitrase, an activity that reduces nitrotyrosine immunoreactivity in proteins
PNAS 2003 100: 5634-5639; published online before print April 28 2003, 10.1073/pnas.1131756100 [Abstract] [Full Text] [PDF]  

James F. Carey, Sharon J. Schultz, Lisa Sisson, Thomas G. Fazzio, and James J. Champoux

DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the protein
PNAS 2003 100: 5640-5645; published online before print April 23 2003, 10.1073/pnas.1031537100 [Abstract] [Full Text] [PDF]  

Peter S. Brzovic, Jennifer R. Keeffe, Hiroyuki Nishikawa, Keiko Miyamoto, David Fox, III, Mamoru Fukuda, Tomohiko Ohta, and Rachel Klevit

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex
PNAS 2003 100: 5646-5651; published online before print May 5 2003, 10.1073/pnas.0836054100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Takashi Moriguchi, Hozumi Motohashi, Tomonori Hosoya, Osamu Nakajima, Satoru Takahashi, Seiichiroh Ohsako, Yasunobu Aoki, Noriko Nishimura, Chiharu Tohyama, Yoshiaki Fujii-Kuriyama, and Masayuki Yamamoto

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse
PNAS 2003 100: 5652-5657; published online before print May 1 2003, 10.1073/pnas.1037886100 [Abstract] [Full Text] [PDF]  

Lan Chen, Deborah Walker, Binyuan Sun, Yanan Hu, Suzanne Walker, and Daniel Kahne

Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate
PNAS 2003 100: 5658-5663; published online before print April 24 2003, 10.1073/pnas.0931492100 [Abstract] [Full Text] [PDF]  

Robert E. Moore, Youngwoo Kim, and Caroline C. Philpott

The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae
PNAS 2003 100: 5664-5669; published online before print April 29 2003, 10.1073/pnas.1030323100 [Abstract] [Full Text] [PDF]  

Devkumar Mustafi, Angela Bekesi, Beata G. Vertessy, and Marvin W. Makinen

Catalytic and structural role of the metal ion in dUTP pyrophosphatase
PNAS 2003 100: 5670-5675; published online before print April 29 2003, 10.1073/pnas.1031504100 [Abstract] [Full Text] [PDF]  

Liang Feng, Debra Tumbula-Hansen, Helen Toogood, and Dieter Söll

Expanding tRNA recognition of a tRNA synthetase by a single amino acid change
PNAS 2003 100: 5676-5681; published online before print May 1 2003, 10.1073/pnas.0631525100 [Abstract] [Full Text] [PDF]  

Randy M. Berka, Xianju Cui, and Charles Yanofsky

Genomewide transcriptional changes associated with genetic alterations and nutritional supplementation affecting tryptophan metabolism in Bacillus subtilis
PNAS 2003 100: 5682-5687; published online before print April 28 2003, 10.1073/pnas.1031606100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Bao D. Nguyen, Karen L. Abbott, Krzysztof Potempa, Michael S. Kobor, Jacques Archambault, Jack Greenblatt, Pascale Legault, and James G. Omichinski

NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1
PNAS 2003 100: 5688-5693; published online before print May 5 2003, 10.1073/pnas.1031524100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Andreas C. Joerger, Sebastian Mayer, and Alan R. Fersht

Mimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity
PNAS 2003 100: 5694-5699; published online before print April 23 2003, 10.1073/pnas.0531477100 [Abstract] [Full Text] [PDF]  

Mahadeb Pal and Donal S. Luse

The initiation-elongation transition: Lateral mobility of RNA in RNA polymerase II complexes is greatly reduced at +8/+9 and absent by +23
PNAS 2003 100: 5700-5705; published online before print April 28 2003, 10.1073/pnas.1037057100 [Abstract] [Full Text] [PDF]  

Jeanette I. Webster, Leonardo H. Tonelli, Mahtab Moayeri, S. Stoney Simons, Jr., Stephen H. Leppla, and Esther M. Sternberg

Anthrax lethal factor represses glucocorticoid and progesterone receptor activity
PNAS 2003 100: 5706-5711; published online before print April 30 2003, 10.1073/pnas.1036973100 [Abstract] [Full Text] [PDF]  

Ka Bian, Zhonghong Gao, Norman Weisbrodt, and Ferid Murad

The nature of heme/iron-induced protein tyrosine nitration
PNAS 2003 100: 5712-5717; published online before print April 22 2003, 10.1073/pnas.0931291100 [Abstract] [Full Text] [PDF]  

Sunitha M. Singh and Neal F. Lue

Ever shorter telomere 1 (EST1)-dependent reverse transcription by Candida telomerase in vitro: Evidence in support of an activating function
PNAS 2003 100: 5718-5723; published online before print April 25 2003, 10.1073/pnas.1036868100 [Abstract] [Full Text] [PDF]  

Ralph Feltens, Markus Gößringer, Dagmar K. Willkomm, Henning Urlaub, and Roland K. Hartmann

An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains
PNAS 2003 100: 5724-5729; published online before print April 28 2003, 10.1073/pnas.0931462100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biophysics

Ana-Rosa Viguera and Luis Serrano

Hydrogen-exchange stability analysis of Bergerac-Src homology 3 variants allows the characterization of a folding intermediate in equilibrium
PNAS 2003 100: 5730-5735; published online before print April 28 2003, 10.1073/pnas.0837456100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neali Armstrong, Mark Mayer, and Eric Gouaux

Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes
PNAS 2003 100: 5736-5741; published online before print May 2 2003, 10.1073/pnas.1037393100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Franc Avbelj and Robert L. Baldwin

Role of backbone solvation and electrostatics in generating preferred peptide backbone conformations: Distributions of phi
PNAS 2003 100: 5742-5747; published online before print April 22 2003, 10.1073/pnas.1031522100 [Abstract] [Full Text] [PDF]  

Roland Thar and Michael Kühl

Bacteria are not too small for spatial sensing of chemical gradients: An experimental evidence
PNAS 2003 100: 5748-5753; published online before print April 28 2003, 10.1073/pnas.1030795100 [Abstract] [Full Text] [PDF]  

Maa emaar, Sotir Zahariev, Jakob J. Lopez, Oliviero Carugo, Jonathan A. Jones, P. J. Hore, and Sándor Pongor

Oxidative folding intermediates with nonnative disulfide bridges between adjacent cysteine residues
PNAS 2003 100: 5754-5759; published online before print April 30 2003, 10.1073/pnas.2225470100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

S. Vorobiev, B. Strokopytov, D. G. Drubin, C. Frieden, S. Ono, J. Condeelis, P. A. Rubenstein, and S. C. Almo

The structure of nonvertebrate actin: Implications for the ATP hydrolytic mechanism
PNAS 2003 100: 5760-5765; published online before print May 5 2003, 10.1073/pnas.0832273100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mario Milani, Pierre-Yves Savard, Hugues Ouellet, Paolo Ascenzi, Michel Guertin, and Martino Bolognesi

A TyrCD1/TrpG8 hydrogen bond network and a TyrB10TyrCD1 covalent link shape the heme distal site of Mycobacterium tuberculosis hemoglobin O
PNAS 2003 100: 5766-5771; published online before print April 28 2003, 10.1073/pnas.1037676100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Buyong Ma, Tal Elkayam, Haim Wolfson, and Ruth Nussinov

Protein-protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfaces
PNAS 2003 100: 5772-5777; published online before print May 1 2003, 10.1073/pnas.1030237100 [Abstract] [Full Text] [PDF]  

Cell Biology

Nick Devoogdt, Gholamreza Hassanzadeh Ghassabeh, Jing Zhang, Lea Brys, Patrick De Baetselier, and Hilde Revets

Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells
PNAS 2003 100: 5778-5782; published online before print May 5 2003, 10.1073/pnas.1037154100 [Abstract] [Full Text] [PDF]  

Sojin Shikano and Min Li

Membrane receptor trafficking: Evidence of proximal and distal zones conferred by two independent endoplasmic reticulum localization signals
PNAS 2003 100: 5783-5788; published online before print April 30 2003, 10.1073/pnas.1031748100 [Abstract] [Full Text] [PDF]  

Xiaoqi Liu and Raymond L. Erikson

Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells
PNAS 2003 100: 5789-5794; published online before print May 5 2003, 10.1073/pnas.1031523100 [Abstract] [Full Text] [PDF]  

Sebastian Schuck, Masanori Honsho, Kim Ekroos, Andrej Shevchenko, and Kai Simons

Resistance of cell membranes to different detergents
PNAS 2003 100: 5795-5800; published online before print April 29 2003, 10.1073/pnas.0631579100 [Abstract] [Full Text] [PDF] [Supporting Table]  

M. van der Laan, M. L. Urbanus, C. M. ten Hagen-Jongman, N. Nouwen, B. Oudega, N. Harms, A. J. M. Driessen, and J. Luirink

A conserved function of YidC in the biogenesis of respiratory chain complexes
PNAS 2003 100: 5801-5806; published online before print April 30 2003, 10.1073/pnas.0636761100 [Abstract] [Full Text] [PDF]  

Masako Miura, Stan Gronthos, Mingrui Zhao, Bai Lu, Larry W. Fisher, Pamela Gehron Robey, and Songtao Shi

SHED: Stem cells from human exfoliated deciduous teeth
PNAS 2003 100: 5807-5812; published online before print April 25 2003, 10.1073/pnas.0937635100 [Abstract] [Full Text] [PDF]  

Leonard J. Foster, Carmen L. de Hoog, and Matthias Mann

Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors
PNAS 2003 100: 5813-5818; published online before print April 30 2003, 10.1073/pnas.0631608100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Julia Gorelik, Andrew I. Shevchuk, Gregory I. Frolenkov, Ivan A. Diakonov, Max J. Lab, Corné J. Kros, Guy P. Richardson, Igor Vodyanoy, Christopher R. W. Edwards, David Klenerman, and Yuri E. Korchev

Dynamic assembly of surface structures in living cells
PNAS 2003 100: 5819-5822; published online before print April 29 2003, 10.1073/pnas.1030502100 [Abstract] [Full Text] [PDF] [Supporting Movie] [Supporting Movie]  

Janet M. Cronshaw and Michael J. Matunis

The nuclear pore complex protein ALADIN is mislocalized in triple A syndrome
PNAS 2003 100: 5823-5827; published online before print May 2 2003, 10.1073/pnas.1031047100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Kenji Mizuseki, Tatsunori Sakamoto, Kiichi Watanabe, Keiko Muguruma, Makoto Ikeya, Ayaka Nishiyama, Akiko Arakawa, Hirofumi Suemori, Norio Nakatsuji, Hiroshi Kawasaki, Fujio Murakami, and Yoshiki Sasai

Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells
PNAS 2003 100: 5828-5833; published online before print April 30 2003, 10.1073/pnas.1037282100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Teruya Nakamura, Motoaki Sano, Zhou Songyang, and Michael D. Schneider

A Wnt- and -catenin-dependent pathway for mammalian cardiac myogenesis
PNAS 2003 100: 5834-5839; published online before print April 28 2003, 10.1073/pnas.0935626100 [Abstract] [Full Text] [PDF]  

Mortaza Bonyadi, Stephen D. Waldman, Danmei Liu, Jane E. Aubin, Marc D. Grynpas, and William L. Stanford

Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice
PNAS 2003 100: 5840-5845; published online before print May 5 2003, 10.1073/pnas.1036475100 [Abstract] [Full Text] [PDF]  

Liang Schweizer, Denise Nellen, and Konrad Basler

Requirement for Pangolin/dTCF in Drosophila Wingless signaling
PNAS 2003 100: 5846-5851; published online before print May 1 2003, 10.1073/pnas.1037533100 [Abstract] [Full Text] [PDF]  

Ecology

Paul F. Doherty, Jr., Gabriele Sorci, J. Andrew Royle, James E. Hines, James D. Nichols, and Thierry Boulinier From the Cover: Sexual selection affects local extinction and turnover in bird communities PNAS 2003 100: 5858-5862; published online before print April 7 2003, 10.1073/pnas.0836953100 [Abstract] [Full Text] [PDF]   See Commentary on page 5576

Claudia Mettke-Hofmann and Eberhard Gwinner

Long-term memory for a life on the move
PNAS 2003 100: 5863-5866; published online before print April 28 2003, 10.1073/pnas.1037505100 [Abstract] [Full Text] [PDF]  

Evolution

Drude Molbo, Carlos A. Machado, Jan G. Sevenster, Laurent Keller, and Edward Allen Herre

Cryptic species of fig-pollinating wasps: Implications for the evolution of the fig-wasp mutualism, sex allocation, and precision of adaptation
PNAS 2003 100: 5867-5872; published online before print April 24 2003, 10.1073/pnas.0930903100 [Abstract] [Full Text] [PDF]  

Allon Goldberg, Derek E. Wildman, Timothy R. Schmidt, Maik Hüttemann, Morris Goodman, Mark L. Weiss, and Lawrence I. Grossman

Adaptive evolution of cytochrome c oxidase subunit VIII in anthropoid primates
PNAS 2003 100: 5873-5878; published online before print April 25 2003, 10.1073/pnas.0931463100 [Abstract] [Full Text] [PDF]  

Jennifer Pastorini, Urs Thalmann, and Robert D. Martin

A molecular approach to comparative phylogeography of extant Malagasy lemurs
PNAS 2003 100: 5879-5884; published online before print April 28 2003, 10.1073/pnas.1031673100 [Abstract] [Full Text] [PDF]  

Xavier Bailly, Riwanon Leroy, Susan Carney, Olivier Collin, Franck Zal, André Toulmond, and Didier Jollivet

The loss of the hemoglobin H₂S-binding function in annelids from sulfide-free habitats reveals molecular adaptation driven by Darwinian positive selection
PNAS 2003 100: 5885-5890; published online before print April 29 2003, 10.1073/pnas.1037686100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Genetics

Maya K. Leabman, Conrad C. Huang, Joseph DeYoung, Elaine J. Carlson, Travis R. Taylor, Melanie de la Cruz, Susan J. Johns, Doug Stryke, Michiko Kawamoto, Thomas J. Urban, Deanna L. Kroetz, Thomas E. Ferrin, Andrew G. Clark, Neil Risch, Ira Herskowitz, Kathleen M. Giacomini, and Pharmacogenetics of Membrane Transporters Investigators

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints
PNAS 2003 100: 5896-5901; published online before print April 28 2003, 10.1073/pnas.0730857100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Yan Shu, Maya K. Leabman, Bo Feng, Lara M. Mangravite, Conrad C. Huang, Doug Stryke, Michiko Kawamoto, Susan J. Johns, Joseph DeYoung, Elaine Carlson, Thomas E. Ferrin, Ira Herskowitz, Kathleen M. Giacomini, and Pharmacogenetics of Membrane Transporters Investigators

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1
PNAS 2003 100: 5902-5907; published online before print April 28 2003, 10.1073/pnas.0730858100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Paul J. Goodfellow, Barbara M. Buttin, Thomas J. Herzog, Janet S. Rader, Randall K. Gibb, Elizabeth Swisher, Katherine Look, Ken C. Walls, Ming-Yu Fan, and David G. Mutch

Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers
PNAS 2003 100: 5908-5913; published online before print May 5 2003, 10.1073/pnas.1030231100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Allan C. Froehlich, Jennifer J. Loros, and Jay C. Dunlap

Rhythmic binding of a WHITE COLLAR-containing complex to the frequency promoter is inhibited by FREQUENCY
PNAS 2003 100: 5914-5919; published online before print April 24 2003, 10.1073/pnas.1030057100 [Abstract] [Full Text] [PDF]  

Raouf Alami, Yuhong Fan, Stephanie Pack, Timothy M. Sonbuchner, Arnaud Besse, Qingcong Lin, John M. Greally, Arthur I. Skoultchi, and Eric E. Bouhassira

Mammalian linker-histone subtypes differentially affect gene expression in vivo
PNAS 2003 100: 5920-5925; published online before print April 28 2003, 10.1073/pnas.0736105100 [Abstract] [Full Text] [PDF]  

Robi D. Mitra, Vincent L. Butty, Jay Shendure, Benjamin R. Williams, David E. Housman, and George M. Church

Digital genotyping and haplotyping with polymerase colonies
PNAS 2003 100: 5926-5931; published online before print May 2 2003, 10.1073/pnas.0936399100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Zhijun Duan and Marshall Horwitz

Targets of the transcriptional repressor oncoprotein Gfi-1
PNAS 2003 100: 5932-5937; published online before print April 29 2003, 10.1073/pnas.1031694100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Ping Cheng, Qiyang He, Yuhong Yang, Lixin Wang, and Yi Liu

Functional conservation of light, oxygen, or voltage domains in light sensing
PNAS 2003 100: 5938-5943; published online before print April 28 2003, 10.1073/pnas.1031791100 [Abstract] [Full Text] [PDF]  

Jesper Tegnér, M. K. Stephen Yeung, Jeff Hasty, and James J. Collins

Reverse engineering gene networks: Integrating genetic perturbations with dynamical modeling
PNAS 2003 100: 5944-5949; published online before print May 1 2003, 10.1073/pnas.0933416100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Barbara L. Apostol, Alexsey Kazantsev, Simona Raffioni, Katalin Illes, Judit Pallos, Laszlo Bodai, Natalia Slepko, James E. Bear, Frank B. Gertler, Steven Hersch, David E. Housman, J. Lawrence Marsh, and Leslie Michels Thompson

A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila
PNAS 2003 100: 5950-5955; published online before print May 1 2003, 10.1073/pnas.2628045100 [Abstract] [Full Text] [PDF]  

Rossano Cesari, Eric S. Martin, George A. Calin, Francesca Pentimalli, Roberta Bichi, Holly McAdams, Francesco Trapasso, Alessandra Drusco, Masayoshi Shimizu, Valeria Masciullo, Giuseppina d'Andrilli, Giovanni Scambia, Maria Cristina Picchio, Hansjuerg Alder, Andrew K. Godwin, and Carlo M. Croce

Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27
PNAS 2003 100: 5956-5961; published online before print April 28 2003, 10.1073/pnas.0931262100 [Abstract] [Full Text] [PDF]  

Li Lin, Yao-Guang Liu, Xinping Xu, and Baojian Li

Efficient linking and transfer of multiple genes by a multigene assembly and transformation vector system
PNAS 2003 100: 5962-5967; published online before print April 28 2003, 10.1073/pnas.0931425100 [Abstract] [Full Text] [PDF]  

Ricardo V. Abdelnoor, Ryan Yule, Annakaisa Elo, Alan C. Christensen, Gilbert Meyer-Gauen, and Sally A. Mackenzie

Substoichiometric shifting in the plant mitochondrial genome is influenced by a gene homologous to MutS
PNAS 2003 100: 5968-5973; published online before print May 1 2003, 10.1073/pnas.1037651100 [Abstract] [Full Text] [PDF]  

Xiao-Jun Ma, Ranelle Salunga, J. Todd Tuggle, Justin Gaudet, Edward Enright, Philip McQuary, Terry Payette, Maria Pistone, Kimberly Stecker, Brian M. Zhang, Yi-Xiong Zhou, Heike Varnholt, Barbara Smith, Michelle Gadd, Erica Chatfield, Jessica Kessler, Thomas M. Baer, Mark G. Erlander, and Dennis C. Sgroi

Gene expression profiles of human breast cancer progression
PNAS 2003 100: 5974-5979; published online before print April 24 2003, 10.1073/pnas.0931261100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Shun-Wen Lu, Scott Kroken, Bee-Na Lee, Barbara Robbertse, Alice C. L. Churchill, O. C. Yoder, and B. Gillian Turgeon

A novel class of gene controlling virulence in plant pathogenic ascomycete fungi
PNAS 2003 100: 5980-5985; published online before print May 2 2003, 10.1073/pnas.0931375100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Susumu Nakae, Shinobu Saijo, Reiko Horai, Katsuko Sudo, Shigeo Mori, and Yoichiro Iwakura

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
PNAS 2003 100: 5986-5990; published online before print April 29 2003, 10.1073/pnas.1035999100 [Abstract] [Full Text] [PDF]  

Svenja Stöven, Neal Silverman, Anna Junell, Marika Hedengren-Olcott, Deniz Erturk, Ylva Engström, Tom Maniatis, and Dan Hultmark

Caspase-mediated processing of the Drosophila NF-B factor Relish
PNAS 2003 100: 5991-5996; published online before print May 5 2003, 10.1073/pnas.1035902100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Tara Stanton, Sally Boxall, Kouzo Hirai, Ritu Dawes, Susan Tonks, Tomoyo Yasui, Yasushi Kanaoka, Nadira Yuldasheva, Osamu Ishiko, Walter Bodmer, Peter C. L. Beverley, and Elma Z. Tchilian

A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression
PNAS 2003 100: 5997-6002; published online before print April 25 2003, 10.1073/pnas.0931490100 [Abstract] [Full Text] [PDF]  

Jan Czyzyk, Jennifer L. Brogdon, Abdallah Badou, Octavian Henegariu, Paula Preston Hurlburt, Richard Flavell, and Kim Bottomly

Activation of CD4 T cells by Raf-independent effectors of Ras
PNAS 2003 100: 6003-6008; published online before print April 29 2003, 10.1073/pnas.1031494100 [Abstract] [Full Text] [PDF]  

Arati B. Kamath, Lisheng Wang, Hiranmoy Das, Lin Li, Vernon N. Reinhold, and Jack F. Bukowski

Antigens in tea-beverage prime human V2V2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses
PNAS 2003 100: 6009-6014; published online before print April 28 2003, 10.1073/pnas.1035603100 [Abstract] [Full Text] [PDF]  

Lukas Hunziker, Adrian Ciurea, Mike Recher, Hans Hengartner, and Rolf M. Zinkernagel

Public versus personal serotypes of a viral quasispecies
PNAS 2003 100: 6015-6020; published online before print May 2 2003, 10.1073/pnas.1031671100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Bruno Martin, Christine Bourgeois, Nicole Dautigny, and Bruno Lucas

On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4⁺ T cells
PNAS 2003 100: 6021-6026; published online before print April 28 2003, 10.1073/pnas.1037754100 [Abstract] [Full Text] [PDF]  

Medical Sciences

L. A. Fitzpatrick, E. Buzas, T. J. Gagne, A. Nagy, C. Horvath, V. Ferencz, A. Mester, B. Kari, M. Ruan, A. Falus, and J. Barsony

Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss
PNAS 2003 100: 6027-6032; published online before print April 25 2003, 10.1073/pnas.0934373100 [Abstract] [Full Text] [PDF] [Supporting Materials and Methods]  

A. Jonas Ekstrand, Renhai Cao, Meit Björndahl, Susanne Nyström, Ann-Cathrine Jönsson-Rylander, Hessameh Hassani, Bengt Hallberg, Margareta Nordlander, and Yihai Cao

Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing
PNAS 2003 100: 6033-6038; published online before print May 2 2003, 10.1073/pnas.1135965100 [Abstract] [Full Text] [PDF]  

Vladimir P. Torchilin, Anatoly N. Lukyanov, Zhonggao Gao, and Brigitte Papahadjopoulos-Sternberg

Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs
PNAS 2003 100: 6039-6044; published online before print April 25 2003, 10.1073/pnas.0931428100 [Abstract] [Full Text] [PDF]  

A. D. Bradshaw, D. C. Graves, K. Motamed, and E. H. Sage

SPARC-null mice exhibit increased adiposity without significant differences in overall body weight
PNAS 2003 100: 6045-6050; published online before print April 29 2003, 10.1073/pnas.1030790100 [Abstract] [Full Text] [PDF]  

Ian J. Davis, Bae-Li Hsi, Jason D. Arroyo, Sara O. Vargas, Y. Albert Yeh, Gabriela Motyckova, Patricia Valencia, Antonio R. Perez-Atayde, Pedram Argani, Marc Ladanyi, Jonathan A. Fletcher, and David E. Fisher

Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation
PNAS 2003 100: 6051-6056; published online before print April 28 2003, 10.1073/pnas.0931430100 [Abstract] [Full Text] [PDF]  

Susan Moir, Kisani M. Ogwaro, Angela Malaspina, Joshua Vasquez, Eileen T. Donoghue, Claire W. Hallahan, Shuying Liu, Linda A. Ehler, Marie A. Planta, Shyamasundaran Kottilil, Tae-Wook Chun, and Anthony S. Fauci

Perturbations in B cell responsiveness to CD4⁺ T cell help in HIV-infected individuals
PNAS 2003 100: 6057-6062; published online before print May 1 2003, 10.1073/pnas.0730819100 [Abstract] [Full Text] [PDF]  

Nam-On Ku, Jama M. Darling, Sheri M. Krams, Carlos O. Esquivel, Emmet B. Keeffe, Richard K. Sibley, Young Moo Lee, Teresa L. Wright, and M. Bishr Omary

Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies
PNAS 2003 100: 6063-6068; published online before print April 30 2003, 10.1073/pnas.0936165100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Christine Lonjou, Weihua Zhang, Andrew Collins, William J. Tapper, Eiram Elahi, Nikolas Maniatis, and Newton E. Morton

Linkage disequilibrium in human populations
PNAS 2003 100: 6069-6074; published online before print April 29 2003, 10.1073/pnas.1031521100 [Abstract] [Full Text] [PDF]  

Irina Smirnova, Navjiwan Mann, Annemiek Dols, H. H. Derkx, Martin L. Hibberd, Michael Levin, and Bruce Beutler

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
PNAS 2003 100: 6075-6080; published online before print May 2 2003, 10.1073/pnas.1031605100 [Abstract] [Full Text] [PDF]  

Guangping Gao, Mauricio R. Alvira, Suryanarayan Somanathan, You Lu, Luk H. Vandenberghe, John J. Rux, Roberto Calcedo, Julio Sanmiguel, Zahra Abbas, and James M. Wilson

Adeno-associated viruses undergo substantial evolution in primates during natural infections
PNAS 2003 100: 6081-6086; published online before print April 25 2003, 10.1073/pnas.0937739100 [Abstract] [Full Text] [PDF]  

Cecilia M. P. Rodrigues, Susana Solá, Zhenhong Nan, Rui E. Castro, Paulo S. Ribeiro, Walter C. Low, and Clifford J. Steer

Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats
PNAS 2003 100: 6087-6092; published online before print April 29 2003, 10.1073/pnas.1031632100 [Abstract] [Full Text] [PDF]  

Paul Brown, Richard Meyer, Franco Cardone, and Maurizio Pocchiari

Ultra-high-pressure inactivation of prion infectivity in processed meat: A practical method to prevent human infection
PNAS 2003 100: 6093-6097; published online before print May 5 2003, 10.1073/pnas.1031826100 [Abstract] [Full Text] [PDF]  

Prabir Ray, Yvan Devaux, Donna B. Stolz, Manohar Yarlagadda, Simon C. Watkins, Yunbiao Lu, Li Chen, Xiao-fang Yang, and Anuradha Ray

Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia
PNAS 2003 100: 6098-6103; published online before print May 5 2003, 10.1073/pnas.1031851100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Davor Pavlovi, David C. A. Neville, Olivier Argaud, Baruch Blumberg, Raymond A. Dwek, Wolfgang B. Fischer, and Nicole Zitzmann

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives
PNAS 2003 100: 6104-6108; published online before print April 28 2003, 10.1073/pnas.1031527100 [Abstract] [Full Text] [PDF]  

Hong Chen, Martin Hewison, Bing Hu, and John S. Adams

Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: A cause of vitamin D resistance
PNAS 2003 100: 6109-6114; published online before print April 25 2003, 10.1073/pnas.1031395100 [Abstract] [Full Text] [PDF]  

Microbiology

Matthew P. DeLisa, Danielle Tullman, and George Georgiou

Folding quality control in the export of proteins by the bacterial twin-arginine translocation pathway
PNAS 2003 100: 6115-6120; published online before print April 29 2003, 10.1073/pnas.0937838100 [Abstract] [Full Text] [PDF]  

Scott E. Converse, Joseph D. Mougous, Michael D. Leavell, Julie A. Leary, Carolyn R. Bertozzi, and Jeffery S. Cox

MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
PNAS 2003 100: 6121-6126; published online before print April 30 2003, 10.1073/pnas.1030024100 [Abstract] [Full Text] [PDF]  

Nada Jabado, Patricia Cuellar-Mata, Sergio Grinstein, and Philippe Gros

Iron chelators modulate the fusogenic properties of Salmonella-containing phagosomes
PNAS 2003 100: 6127-6132; published online before print April 23 2003, 10.1073/pnas.0937287100 [Abstract] [Full Text] [PDF]  

A. Sola-Landa, R. S. Moura, and J. F. Martín

The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans
PNAS 2003 100: 6133-6138; published online before print May 2 2003, 10.1073/pnas.0931429100 [Abstract] [Full Text] [PDF]  

Neuroscience

Du-Chu Wu, Peter Teismann, Kim Tieu, Miquel Vila, Vernice Jackson-Lewis, Harry Ischiropoulos, and Serge Przedborski

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
PNAS 2003 100: 6145-6150; published online before print April 29 2003, 10.1073/pnas.0937239100 [Abstract] [Full Text] [PDF]  

Peter Heil and Heinrich Neubauer

A unifying basis of auditory thresholds based on temporal summation
PNAS 2003 100: 6151-6156; published online before print April 30 2003, 10.1073/pnas.1030017100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Stefano L. Sensi, Dien Ton-That, Patrick G. Sullivan, Elizabeth A. Jonas, Kyle R. Gee, Leonard K. Kaczmarek, and John H. Weiss