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COMMENTARIES

Andrew Dillin

The specifics of small interfering RNA specificity
PNAS 2003 100: 6289-6291; published online before print May 16 2003, 10.1073/pnas.1232238100 [Extract] [Full Text] [PDF]  
See companion article on page 6343
See companion article on page 6347

David D. Perkins

A fratricidal fungal prion
PNAS 2003 100: 6292-6294; published online before print May 16 2003, 10.1073/pnas.1332353100 [Extract] [Full Text] [PDF]  
See companion article on page 6616

Peter Henson

Suppression of macrophage inflammatory responses by PPARs
PNAS 2003 100: 6295-6296; published online before print May 19 2003, 10.1073/pnas.1232410100 [Extract] [Full Text] [PDF]  
See companion article on page 6712

PHYSICAL SCIENCES

Applied Physical Sciences

Chunhai Fan, Shu Wang, Janice W. Hong, Guillermo C. Bazan, Kevin W. Plaxco, and Alan J. Heeger

Beyond superquenching: Hyper-efficient energy transfer from conjugated polymers to gold nanoparticles
PNAS 2003 100: 6297-6301; published online before print May 15 2003, 10.1073/pnas.1132025100 [Abstract] [Full Text] [PDF]  

Chemistry

David Gidalevitz, Yuji Ishitsuka, Adrian S. Muresan, Oleg Konovalov, Alan J. Waring, Robert I. Lehrer, and Ka Yee C. Lee

Interaction of antimicrobial peptide protegrin with biomembranes
PNAS 2003 100: 6302-6307; published online before print May 8 2003, 10.1073/pnas.0934731100 [Abstract] [Full Text] [PDF]  

Engineering

David Gabriel and Marc A. Deshusses

Retrofitting existing chemical scrubbers to biotrickling filters for H₂S emission control
PNAS 2003 100: 6308-6312; published online before print May 9 2003, 10.1073/pnas.0731894100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Mathematics

Fan Chung, Linyuan Lu, and Van Vu

Spectra of random graphs with given expected degrees
PNAS 2003 100: 6313-6318; published online before print May 12 2003, 10.1073/pnas.0937490100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Psychology

Lin Chen, Shaowu Zhang, and Mandyam V. Srinivasan

Global perception in small brains: Topological pattern recognition in honey bees
PNAS 2003 100: 6884-6889; published online before print May 15 2003, 10.1073/pnas.0732090100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Makiko Sato, James Hansen, Dorothy Koch, Andrew Lacis, Reto Ruedy, Oleg Dubovik, Brent Holben, Mian Chin, and Tica Novakov

Global atmospheric black carbon inferred from AERONET
PNAS 2003 100: 6319-6324; published online before print May 13 2003, 10.1073/pnas.0731897100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Carrie A. Hendricks, Karen H. Almeida, Molly S. Stitt, Vidya S. Jonnalagadda, Rebecca E. Rugo, G. Foster Kerrison, and Bevin P. Engelward

Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice
PNAS 2003 100: 6325-6330; published online before print May 15 2003, 10.1073/pnas.1232231100 [Abstract] [Full Text] [PDF]  

Lorcan T. Allen, Edward J. P. Fox, Irena Blute, Zoe D. Kelly, Yuri Rochev, Alan K. Keenan, Kenneth A. Dawson, and William M. Gallagher

Interaction of soft condensed materials with living cells: Phenotype/transcriptome correlations for the hydrophobic effect
PNAS 2003 100: 6331-6336; published online before print May 13 2003, 10.1073/pnas.1031426100 [Abstract] [Full Text] [PDF]  

Biochemistry

Christophe Le Clainche, Dominique Pantaloni, and Marie-France Carlier

ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays
PNAS 2003 100: 6337-6342; published online before print May 12 2003, 10.1073/pnas.1130513100 [Abstract] [Full Text] [PDF]  

Jen-Tsan Chi, Howard Y. Chang, Nancy N. Wang, Dustin S. Chang, Nina Dunphy, and Patrick O. Brown Genomewide view of gene silencing by small interfering RNAs PNAS 2003 100: 6343-6346; published online before print May 2 2003, 10.1073/pnas.1037853100 [Abstract] [Full Text] [PDF]   See Commentary on page 6289

Dimitri Semizarov, Leigh Frost, Aparna Sarthy, Paul Kroeger, Donald N. Halbert, and Stephen W. Fesik Specificity of short interfering RNA determined through gene expression signatures PNAS 2003 100: 6347-6352; published online before print May 13 2003, 10.1073/pnas.1131959100 [Abstract] [Full Text] [PDF] [Supporting Tables]   See Commentary on page 6289

Anthony C. Forster, Zhongping Tan, Madhavi N. L. Nalam, Hening Lin, Hui Qu, Virginia W. Cornish, and Stephen C. Blacklow

Programming peptidomimetic syntheses by translating genetic codes designed de novo
PNAS 2003 100: 6353-6357; published online before print May 16 2003, 10.1073/pnas.1132122100 [Abstract] [Full Text] [PDF]  

Subrahmanyam S. Chirala, Hua Chang, Martin Matzuk, Lutfi Abu-Elheiga, Jianqiang Mao, Kathleen Mahon, Milton Finegold, and Salih J. Wakil

Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero
PNAS 2003 100: 6358-6363; published online before print May 8 2003, 10.1073/pnas.0931394100 [Abstract] [Full Text] [PDF]  

Peter L. Nagy, Michael L. Cleary, Patrick O. Brown, and Jason D. Lieb

Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin
PNAS 2003 100: 6364-6369; published online before print May 15 2003, 10.1073/pnas.1131966100 [Abstract] [Full Text] [PDF]  

Minako Hoshi, Michio Sato, Shinichiro Matsumoto, Akihiko Noguchi, Kaori Yasutake, Natsuko Yoshida, and Kazuki Sato

Spherical aggregates of -amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3
PNAS 2003 100: 6370-6375; published online before print May 15 2003, 10.1073/pnas.1237107100 [Abstract] [Full Text] [PDF]  

Jason G. Williams, Kamesh Pappu, and Sharon L. Campbell

Structural and biochemical studies of p21^Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange
PNAS 2003 100: 6376-6381; published online before print May 9 2003, 10.1073/pnas.1037299100 [Abstract] [Full Text] [PDF]  

W. Taylor Kimberly, Matthew J. LaVoie, Beth L. Ostaszewski, Wenjuan Ye, Michael S. Wolfe, and Dennis J. Selkoe

-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
PNAS 2003 100: 6382-6387; published online before print May 9 2003, 10.1073/pnas.1037392100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Zhuan-Fen Cheng and Murray P. Deutscher

Quality control of ribosomal RNA mediated by polynucleotide phosphorylase and RNase R
PNAS 2003 100: 6388-6393; published online before print May 12 2003, 10.1073/pnas.1231041100 [Abstract] [Full Text] [PDF]  

Mohan L. Gupta, Jr., Claudia J. Bode, Gunda I. Georg, and Richard H. Himes

Understanding tubulin–Taxol interactions: Mutations that impart Taxol binding to yeast tubulin
PNAS 2003 100: 6394-6397; published online before print May 9 2003, 10.1073/pnas.1131967100 [Abstract] [Full Text] [PDF]  

Masashi Kato and William Wickner

Vam10p defines a Sec18p-independent step of priming that allows yeast vacuole tethering
PNAS 2003 100: 6398-6403; published online before print May 14 2003, 10.1073/pnas.1132162100 [Abstract] [Full Text] [PDF]  

Trudy Correia, Venizelos Papayannopoulos, Vladislav Panin, Pamela Woronoff, Jin Jiang, Thomas F. Vogt, and Kenneth D. Irvine

Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila
PNAS 2003 100: 6404-6409; published online before print May 12 2003, 10.1073/pnas.1131007100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Giedrius Sasnauskas, Stephen E. Halford, and Virginijus Siksnys

How the BfiI restriction enzyme uses one active site to cut two DNA strands
PNAS 2003 100: 6410-6415; published online before print May 15 2003, 10.1073/pnas.1131003100 [Abstract] [Full Text] [PDF]  

Matthew Levy and Andrew D. Ellington

Exponential growth by cross-catalytic cleavage of deoxyribozymogens
PNAS 2003 100: 6416-6421; published online before print May 12 2003, 10.1073/pnas.1130145100 [Abstract] [Full Text] [PDF]  

Camilla O. Samuelsen, Vera Baraznenok, Olga Khorosjutina, Henrik Spåhr, Thomas Kieselbach, Steen Holmberg, and Claes M. Gustafsson

TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution
PNAS 2003 100: 6422-6427; published online before print May 8 2003, 10.1073/pnas.1030497100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Juan M. Capasso, Christopher J. Rivard, Laura M. Enomoto, and Tomas Berl

Chloride, not sodium, stimulates expression of the subunit of Na/K-ATPase and activates JNK in response to hypertonicity in mouse IMCD3 cells
PNAS 2003 100: 6428-6433; published online before print May 13 2003, 10.1073/pnas.1130871100 [Abstract] [Full Text] [PDF]  

Biophysics

Walter Steffen, David Smith, and John Sleep

The working stroke upon myosin–nucleotide complexes binding to actin
PNAS 2003 100: 6434-6439; published online before print May 15 2003, 10.1073/pnas.1231998100 [Abstract] [Full Text] [PDF]  

Isabelle Petitpas, Charles E. Petersen, Chung-Eun Ha, Ananyo A. Bhattacharya, Patricia A. Zunszain, Jamie Ghuman, Nadhipuram V. Bhagavan, and Stephen Curry

Structural basis of albumin–thyroxine interactions and familial dysalbuminemic hyperthyroxinemia
PNAS 2003 100: 6440-6445; published online before print May 12 2003, 10.1073/pnas.1137188100 [Abstract] [Full Text] [PDF]  

Ariel Fernández, József Kardos, L. Ridgway Scott, Yuji Goto, and R. Stephen Berry

Structural defects and the diagnosis of amyloidogenic propensity
PNAS 2003 100: 6446-6451; published online before print May 12 2003, 10.1073/pnas.0731893100 [Abstract] [Full Text] [PDF]  

Jens Bredenbeck, Jan Helbing, Arne Sieg, Tobias Schrader, Wolfgang Zinth, Christian Renner, Raymond Behrendt, Luis Moroder, Josef Wachtveitl, and Peter Hamm

Picosecond conformational transition and equilibration of a cyclic peptide
PNAS 2003 100: 6452-6457; published online before print May 7 2003, 10.1073/pnas.1036583100 [Abstract] [Full Text] [PDF]  

Ana Carolina Zeri, Michael F. Mesleh, Alexander A. Nevzorov, and Stanley J. Opella

Structure of the coat protein in fd filamentous bacteriophage particles determined by solid-state NMR spectroscopy
PNAS 2003 100: 6458-6463; published online before print May 15 2003, 10.1073/pnas.1132059100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Cell Biology

Neelu Yadav, Jaeho Lee, Jeesun Kim, Jianjun Shen, Mickey C.-T. Hu, C. Marcelo Aldaz, and Mark T. Bedford

Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice
PNAS 2003 100: 6464-6468; published online before print May 19 2003, 10.1073/pnas.1232272100 [Abstract] [Full Text] [PDF]  

Yan Feng, Sidney Yu, Troy K. R. Lasell, Ashutosh P. Jadhav, Eric Macia, Pierre Chardin, Paul Melancon, Michael Roth, Timothy Mitchison, and Tomas Kirchhausen

Exo1: A new chemical inhibitor of the exocytic pathway
PNAS 2003 100: 6469-6474; published online before print May 8 2003, 10.1073/pnas.0631766100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Piergiorgio Percipalle, Nathalie Fomproix, Karin Kylberg, Francesc Miralles, Birgitta Björkroth, Bertil Daneholt, and Neus Visa

An actin–ribonucleoprotein interaction is involved in transcription by RNA polymerase II
PNAS 2003 100: 6475-6480; published online before print May 12 2003, 10.1073/pnas.1131933100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Daniel Gibbs, Junko Kitamoto, and David S. Williams

Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein
PNAS 2003 100: 6481-6486; published online before print May 12 2003, 10.1073/pnas.1130432100 [Abstract] [Full Text] [PDF]  

Hiroshi Kubota, Mary R. Avarbock, and Ralph L. Brinster

Spermatogonial stem cells share some, but not all, phenotypic and functional characteristics with other stem cells
PNAS 2003 100: 6487-6492; published online before print May 8 2003, 10.1073/pnas.0631767100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Paula A. Giardini, Daniel A. Fletcher, and Julie A. Theriot

Compression forces generated by actin comet tails on lipid vesicles
PNAS 2003 100: 6493-6498; published online before print May 8 2003, 10.1073/pnas.1031670100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Shi Shu, Xiong Liu, and Edward D. Korn

Dictyostelium and Acanthamoeba myosin II assembly domains go to the cleavage furrow of Dictyostelium myosin II-null cells
PNAS 2003 100: 6499-6504; published online before print May 14 2003, 10.1073/pnas.0732155100 [Abstract] [Full Text] [PDF]  

Mirko H. H. Schmidt, Frank B. Furnari, Webster K. Cavenee, and Oliver Bögler

Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization
PNAS 2003 100: 6505-6510; published online before print May 6 2003, 10.1073/pnas.1031790100 [Abstract] [Full Text] [PDF]  

Grzegorz Sowa, Marc Pypaert, David Fulton, and William C. Sessa

The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation
PNAS 2003 100: 6511-6516; published online before print May 12 2003, 10.1073/pnas.1031672100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sara Brunnberg, Katarina Pettersson, Elin Rydin, Jason Matthews, Annika Hanberg, and Ingemar Pongratz

The basic helix–loop–helix–PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription
PNAS 2003 100: 6517-6522; published online before print May 16 2003, 10.1073/pnas.1136688100 [Abstract] [Full Text] [PDF]  

Saghi Ghaffari, Zainab Jagani, Claire Kitidis, Harvey F. Lodish, and Roya Khosravi-Far

Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor
PNAS 2003 100: 6523-6528; published online before print May 15 2003, 10.1073/pnas.0731871100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ann M. Winter-Vann, Barton A. Kamen, Martin O. Bergo, Stephen G. Young, Stepan Melnyk, S. Jill James, and Patrick J. Casey

Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate
PNAS 2003 100: 6529-6534; published online before print May 15 2003, 10.1073/pnas.1135239100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Ronald G. Gregg, Gregory B. Willer, James M. Fadool, John E. Dowling, and Brian A. Link

Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation
PNAS 2003 100: 6535-6540; published online before print May 14 2003, 10.1073/pnas.0631813100 [Abstract] [Full Text] [PDF]  

Thimios A. Mitsiadis, Yvonnick Chéraud, Paul Sharpe, and Josiane Fontaine-Pérus

Development of teeth in chick embryos after mouse neural crest transplantations
PNAS 2003 100: 6541-6545; published online before print May 9 2003, 10.1073/pnas.1137104100 [Abstract] [Full Text] [PDF]  

Alain de Bruin, Lizhao Wu, Harold I. Saavedra, Pamela Wilson, Ying Yang, Thomas J. Rosol, Michael Weinstein, Michael L. Robinson, and Gustavo Leone

Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice
PNAS 2003 100: 6546-6551; published online before print May 5 2003, 10.1073/pnas.1031853100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Bo Shen, Changjiang Li, Zhao Min, Robert B. Meeley, Mitchell C. Tarczynski, and Odd-Arne Olsen

sal1 determines the number of aleurone cell layers in maize endosperm and encodes a class E vacuolar sorting protein
PNAS 2003 100: 6552-6557; published online before print May 15 2003, 10.1073/pnas.0732023100 [Abstract] [Full Text] [PDF]  

Rebecca S. Lamb and Vivian F. Irish

Functional divergence within the APETALA3/PISTILLATA floral homeotic gene lineages
PNAS 2003 100: 6558-6563; published online before print May 13 2003, 10.1073/pnas.0631708100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ecology

Ray Hilborn, Thomas P. Quinn, Daniel E. Schindler, and Donald E. Rogers

Biocomplexity and fisheries sustainability
PNAS 2003 100: 6564-6568; published online before print May 12 2003, 10.1073/pnas.1037274100 [Abstract] [Full Text] [PDF]  

Evolution

Vladimir V. Kapitonov and Jerzy Jurka

Molecular paleontology of transposable elements in the Drosophila melanogaster genome
PNAS 2003 100: 6569-6574; published online before print May 12 2003, 10.1073/pnas.0732024100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Seán G. Brady

Evolution of the army ant syndrome: The origin and long-term evolutionary stasis of a complex of behavioral and reproductive adaptations
PNAS 2003 100: 6575-6579; published online before print May 15 2003, 10.1073/pnas.1137809100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Rosa Tarrío, Francisco Rodríguez-Trelles, and Francisco J. Ayala

A new Drosophila spliceosomal intron position is common in plants
PNAS 2003 100: 6580-6583; published online before print May 15 2003, 10.1073/pnas.0731952100 [Abstract] [Full Text] [PDF]  

Hampton L. Carson

Mate choice theory and the mode of selection in sexual populations
PNAS 2003 100: 6584-6587; published online before print May 12 2003, 10.1073/pnas.0732174100 [Abstract] [Full Text] [PDF]  

Philippe Lemey, Oliver G. Pybus, Bin Wang, Nitin K. Saksena, Marco Salemi, and Anne-Mieke Vandamme

Tracing the origin and history of the HIV-2 epidemic
PNAS 2003 100: 6588-6592; published online before print May 12 2003, 10.1073/pnas.0936469100 [Abstract] [Full Text] [PDF]  

David Caramelli, Carles Lalueza-Fox, Cristiano Vernesi, Martina Lari, Antonella Casoli, Francesco Mallegni, Brunetto Chiarelli, Isabelle Dupanloup, Jaume Bertranpetit, Guido Barbujani, and Giorgio Bertorelle Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans PNAS 2003 100: 6593-6597; published online before print May 12 2003, 10.1073/pnas.1130343100 [Abstract] [Full Text] [PDF] [Supporting Figure]

Adam G. Jones, Glenn I. Moore, Charlotta Kvarnemo, DeEtte Walker, and John C. Avise

Sympatric speciation as a consequence of male pregnancy in seahorses
PNAS 2003 100: 6598-6603; published online before print May 5 2003, 10.1073/pnas.1131969100 [Abstract] [Full Text] [PDF]  

Genetics

Ching-Kang Chen, Pamela Eversole-Cire, Haikun Zhang, Valeria Mancino, Yu-Jiun Chen, Wei He, Theodore G. Wensel, and Melvin I. Simon

Instability of GGL domain-containing RGS proteins in mice lacking the G protein -subunit G5
PNAS 2003 100: 6604-6609; published online before print May 8 2003, 10.1073/pnas.0631825100 [Abstract] [Full Text] [PDF]  

Loukia-Maria Mitsos, Lon R. Cardon, Lynn Ryan, Ronald LaCourse, Robert J. North, and Philippe Gros

Susceptibility to tuberculosis: A locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs
PNAS 2003 100: 6610-6615; published online before print May 9 2003, 10.1073/pnas.1031727100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Henk J. P. Dalstra, Klaas Swart, Alfons J. M. Debets, Sven J. Saupe, and Rolf F. Hoekstra Sexual transmission of the [Het-s] prion leads to meiotic drive in Podospora anserina PNAS 2003 100: 6616-6621; published online before print April 28 2003, 10.1073/pnas.1030058100 [Abstract] [Full Text] [PDF]   See Commentary on page 6292

Maria Kost-Alimova, Hajnalka Kiss, Ludmila Fedorova, Ying Yang, Jan P. Dumanski, George Klein, and Stefan Imreh

Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3
PNAS 2003 100: 6622-6627; published online before print May 8 2003, 10.1073/pnas.0430971100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Ruojin Yao, Zhen Zhang, Xiuxiang An, Brigid Bucci, Deborah L. Perlstein, JoAnne Stubbe, and Mingxia Huang

Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways
PNAS 2003 100: 6628-6633; published online before print May 5 2003, 10.1073/pnas.1131932100 [Abstract] [Full Text] [PDF]  

Radclyffe L. Roberts, Matthew Metz, Dave E. Monks, Matthew Lockwood Mullaney, Tyler Hall, and Eugene W. Nester

Purine synthesis and increased Agrobacterium tumefaciens transformation of yeast and plants
PNAS 2003 100: 6634-6639; published online before print May 9 2003, 10.1073/pnas.1132022100 [Abstract] [Full Text] [PDF]  

Kyungjae Myung, Vincent Pennaneach, Ellen S. Kats, and Richard D. Kolodner

Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability
PNAS 2003 100: 6640-6645; published online before print May 15 2003, 10.1073/pnas.1232239100 [Abstract] [Full Text] [PDF]  

Immunology

Jongdae Lee, Tsung-Hsien Chuang, Vanessa Redecke, Liping She, Paula M. Pitha, Dennis A. Carson, Eyal Raz, and Howard B. Cottam

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
PNAS 2003 100: 6646-6651; published online before print May 8 2003, 10.1073/pnas.0631696100 [Abstract] [Full Text] [PDF]  

Nicholas Kushner, Dong Zhang, Neal Touzjian, Max Essex, Judy Lieberman, and Yichen Lu

A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen
PNAS 2003 100: 6652-6657; published online before print May 9 2003, 10.1073/pnas.1131930100 [Abstract] [Full Text] [PDF]  

Marisa Benagiano, Annalisa Azzurri, Alessandra Ciervo, Amedeo Amedei, Carlo Tamburini, Mauro Ferrari, John L. Telford, Cosima T. Baldari, Sergio Romagnani, Antonio Cassone, Mario M. D'Elios, and Gianfranco Del Prete

T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions
PNAS 2003 100: 6658-6663; published online before print May 9 2003, 10.1073/pnas.1135726100 [Abstract] [Full Text] [PDF]  

Jacek Bania, Evelina Gatti, Hugues Lelouard, Alexandre David, Fanny Cappello, Ekkehard Weber, Voahirana Camosseto, and Philippe Pierre

Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs
PNAS 2003 100: 6664-6669; published online before print May 14 2003, 10.1073/pnas.1131604100 [Abstract] [Full Text] [PDF]  

Inkyu Hwang, Xuefei Shen, and Jonathan Sprent

Direct stimulation of naïve T cells by membrane vesicles from antigen-presenting cells: Distinct roles for CD54 and B7 molecules
PNAS 2003 100: 6670-6675; published online before print May 12 2003, 10.1073/pnas.1131852100 [Abstract] [Full Text] [PDF]  

Miri Paas-Rozner, Michael Sela, and Edna Mozes

A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4⁺ T cells
PNAS 2003 100: 6676-6681; published online before print May 12 2003, 10.1073/pnas.1131898100 [Abstract] [Full Text] [PDF]  

Zheng Cui, Mark C. Willingham, Amy M. Hicks, Martha A. Alexander-Miller, Timothy D. Howard, Gregory A. Hawkins, Mark S. Miller, Holly M. Weir, Wei Du, and Cynthia J. DeLong

Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice
PNAS 2003 100: 6682-6687; published online before print April 30 2003, 10.1073/pnas.1031601100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Emma E. Hamilton-Williams, Stephanie E. Palmer, Brett Charlton, and Robyn M. Slattery

Beta cell MHC class I is a late requirement for diabetes
PNAS 2003 100: 6688-6693; published online before print May 15 2003, 10.1073/pnas.1131954100 [Abstract] [Full Text] [PDF]  

Medical Sciences

Gil-Jin Shim, Ling Wang, Sandra Andersson, Noémi Nagy, Loránd Levente Kis, Qinghong Zhang, Sari Mäkelä, Margaret Warner, and Jan-Åke Gustafsson

Disruption of the estrogen receptor gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis
PNAS 2003 100: 6694-6699; published online before print May 9 2003, 10.1073/pnas.0731830100 [Abstract] [Full Text] [PDF]  

Lazar Mandinov, Anna Mandinova, Stanimir Kyurkchiev, Dobroslav Kyurkchiev, Ivan Kehayov, Vihren Kolev, Raffaella Soldi, Cinzia Bagala, Ebo D. de Muinck, Volkhard Lindner, Mark J. Post, Michael Simons, Stephen Bellum, Igor Prudovsky, and Thomas Maciag

Copper chelation represses the vascular response to injury
PNAS 2003 100: 6700-6705; published online before print May 16 2003, 10.1073/pnas.1231994100 [Abstract] [Full Text] [PDF]  

Gunhild Sommer, Valter Agosti, Imke Ehlers, Ferdinand Rossi, Selim Corbacioglu, Judith Farkas, Malcolm Moore, Katia Manova, Cristina R. Antonescu, and Peter Besmer

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase
PNAS 2003 100: 6706-6711; published online before print May 16 2003, 10.1073/pnas.1037763100 [Abstract] [Full Text] [PDF] [Supporting Information]  

John S. Welch, Mercedes Ricote, Taro E. Akiyama, Frank J. Gonzalez, and Christopher K. Glass PPAR and PPAR negatively regulate specific subsets of lipopolysaccharide and IFN- target genes in macrophages PNAS 2003 100: 6712-6717; published online before print May 9 2003, 10.1073/pnas.1031789100 [Abstract] [Full Text] [PDF] [Supporting Table]   See Commentary on page 6295

Joseph Lotem, Hilah Gal, Rachel Kama, Ninette Amariglio, Gideon Rechavi, Eytan Domany, Leo Sachs, and David Givol

Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes
PNAS 2003 100: 6718-6723; published online before print May 12 2003, 10.1073/pnas.1031695100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Richard S. Hotchkiss, Katherine C. Chang, Mitchell H. Grayson, Kevin W. Tinsley, Benjamin S. Dunne, Christopher G. Davis, Dale F. Osborne, and Irene E. Karl

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis
PNAS 2003 100: 6724-6729; published online before print May 7 2003, 10.1073/pnas.1031788100 [Abstract] [Full Text] [PDF]  

Sherry Weng, Laura Zemany, Kara N. Standley, Deborah V. Novack, Marie La Regina, Carlos Bernal-Mizrachi, Trey Coleman, and Clay F. Semenkovich

3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice
PNAS 2003 100: 6730-6735; published online before print May 13 2003, 10.1073/pnas.1137612100 [Abstract] [Full Text] [PDF]  

V. M. Paralkar, F. Borovecki, H. Z. Ke, K. O. Cameron, B. Lefker, W. A. Grasser, T. A. Owen, M. Li, P. DaSilva-Jardine, M. Zhou, R. L. Dunn, F. Dumont, R. Korsmeyer, P. Krasney, T. A. Brown, D. Plowchalk, S. Vukicevic, and D. D. Thompson

An EP2 receptor-selective prostaglandin E₂ agonist induces bone healing
PNAS 2003 100: 6736-6740; published online before print May 14 2003, 10.1073/pnas.1037343100 [Abstract] [Full Text] [PDF]  

Serhat Erbayraktar, Giovanni Grasso, Alessandra Sfacteria, Qiao-wen Xie, Thomas Coleman, Mads Kreilgaard, Lars Torup, Thomas Sager, Zubeyde Erbayraktar, Necati Gokmen, Osman Yilmaz, Pietro Ghezzi, Pia Villa, Maddalena Fratelli, Simona Casagrande, Marcel Leist, Lone Helboe, Jens Gerwien, Søren Christensen, Marie Aavang Geist, Lars Østergaard Pedersen, Carla Cerami-Hand, Jean-Paul Wuerth, Anthony Cerami, and Michael Brines

Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
PNAS 2003 100: 6741-6746; published online before print May 13 2003, 10.1073/pnas.1031753100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Florian Klein, Niklas Feldhahn, Sanggyu Lee, Hui Wang, Fiammetta Ciuffi, Mirko von Elstermann, María L. Toribio, Heinrich Sauer, Maria Wartenberg, Varun Singh Barath, Martin Krönke, Peter Wernet, Janet D. Rowley, and Markus Müschen

T lymphoid differentiation in human bone marrow
PNAS 2003 100: 6747-6752; published online before print May 8 2003, 10.1073/pnas.1031503100 [Abstract] [Full Text] [PDF]  

Kazumoto Murata, Martin Lechmann, Ming Qiao, Toshiaki Gunji, Harvey J. Alter, and T. Jake Liang

Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection
PNAS 2003 100: 6753-6758; published online before print May 14 2003, 10.1073/pnas.1131929100 [Abstract] [Full Text] [PDF]  

Microbiology

Thomas A. Ericsson, Yasuhiro Takeuchi, Christian Templin, Gary Quinn, Shelli F. Farhadian, James C. Wood, Beth A. Oldmixon, Kristen M. Suling, Jennifer K. Ishii, Yoshinori Kitagawa, Takayuki Miyazawa, Daniel R. Salomon, Robin A. Weiss, and Clive Patience

Identification of receptors for pig endogenous retrovirus
PNAS 2003 100: 6759-6764; published online before print May 9 2003, 10.1073/pnas.1138025100 [Abstract] [Full Text] [PDF] [Supporting Methods]  

Mikhail Prosniak, Anna Zborek, Gwen S. Scott, Anirban Roy, Timothy W. Phares, Hilary Koprowski, and D. Craig Hooper

Differential expression of growth factors at the cellular level in virus-infected brain
PNAS 2003 100: 6765-6770; published online before print May 7 2003, 10.1073/pnas.0430999100 [Abstract] [Full Text] [PDF]  

Reynaldo A. Carabeo, David J. Mead, and Ted Hackstadt

Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion
PNAS 2003 100: 6771-6776; published online before print May 12 2003, 10.1073/pnas.1131289100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Neuroscience

Xinyu Zhao, Tetsuya Ueba, Brian R. Christie, Basam Barkho, Michael J. McConnell, Kinichi Nakashima, Edward S. Lein, Brennan D. Eadie, Andrew R. Willhoite, Alysson R. Muotri, Robert G. Summers, Jerold Chun, Kuo-Fen Lee, and Fred H. Gage

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function
PNAS 2003 100: 6777-6782; published online before print May 14 2003, 10.1073/pnas.1131928100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mark E. Pennesi, Kim A. Howes, Wolfgang Baehr, and Samuel M. Wu

Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice
PNAS 2003 100: 6783-6788; published online before print May 5 2003, 10.1073/pnas.1130102100 [Abstract] [Full Text] [PDF]  

Eric R. Stevens, Manuel Esguerra, Paul M. Kim, Eric A. Newman, Solomon H. Snyder, Kathleen R. Zahs, and Robert F. Miller

D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors
PNAS 2003 100: 6789-6794; published online before print May 15 2003, 10.1073/pnas.1237052100 [Abstract] [Full Text] [PDF]  

Hideyuki Terazono, Tatsushi Mutoh, Shun Yamaguchi, Masaki Kobayashi, Masashi Akiyama, Rhyuta Udo, Shigehiro Ohdo, Hitoshi Okamura, and Shigenobu Shibata

Adrenergic regulation of clock gene expression in mouse liver
PNAS 2003 100: 6795-6800; published online before print May 16 2003, 10.1073/pnas.0936797100 [Abstract] [Full Text] [PDF]  

Wenbin Deng, Paul A. Rosenberg, Joseph J. Volpe, and Frances E. Jensen

Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors
PNAS 2003 100: 6801-6806; published online before print May 12 2003, 10.1073/pnas.1136624100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Jonathan R. Genzen and Daniel S. McGehee

Short- and long-term enhancement of excitatory transmission in the spinal cord dorsal horn by nicotinic acetylcholine receptors
PNAS 2003 100: 6807-6812; published online before print May 14 2003, 10.1073/pnas.1131709100 [Abstract] [Full Text] [PDF]  

Pharmacology

Mario Carta, Olusegun J. Ariwodola, Jeff L. Weiner, and C. Fernando Valenzuela

Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons
PNAS 2003 100: 6813-6818; published online before print May 5 2003, 10.1073/pnas.1137276100 [Abstract] [Full Text] [PDF]  

Physiology

Hiroshi Irie, Irvin B. Krukenkamp, Joep F. F. Brinkmann, Glenn R. Gaudette, Adam E. Saltman, William Jou, Jan F. C. Glatz, Nada A. Abumrad, and Azeddine Ibrahimi

Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids
PNAS 2003 100: 6819-6824; published online before print May 13 2003, 10.1073/pnas.1132094100 [Abstract] [Full Text] [PDF]  

Stacey L. Conarello, Zhihua Li, John Ronan, Ranabir Sinha Roy, Lan Zhu, Guoqiang Jiang, Franklin Liu, John Woods, Emanuel Zycband, David E. Moller, Nancy A. Thornberry, and Bei B. Zhang

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
PNAS 2003 100: 6825-6830; published online before print May 14 2003, 10.1073/pnas.0631828100 [Abstract] [Full Text] [PDF]  

Plant Biology

Petra Epple, Amanda A. Mack, Veronica R. F. Morris, and Jeffery L. Dangl

Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins
PNAS 2003 100: 6831-6836; published online before print May 5 2003, 10.1073/pnas.1130421100 [Abstract] [Full Text] [PDF] [Supporting Information]  

George Theodoris, Noriko Inada, and Michael Freeling

Conservation and molecular dissection of ROUGH SHEATH2 and ASYMMETRIC LEAVES1 function in leaf development
PNAS 2003 100: 6837-6842; published online before print May 15 2003, 10.1073/pnas.1132113100 [Abstract] [Full Text] [PDF]  

Nicolas Bouché, Aaron Fait, David Bouchez, Simon G. Møller, and Hillel Fromm

Mitochondrial succinic-semialdehyde dehydrogenase of the -aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants
PNAS 2003 100: 6843-6848; published online before print May 9 2003, 10.1073/pnas.1037532100 [Abstract] [Full Text] [PDF] [Supporting Movie]  

Henriette Schluepmann, Till Pellny, Anja van Dijken, Sjef Smeekens, and Matthew Paul

Trehalose 6-phosphate is indispensable for carbohydrate utilization and growth in Arabidopsis thaliana
PNAS 2003 100: 6849-6854; published online before print May 14 2003, 10.1073/pnas.1132018100 [Abstract] [Full Text] [PDF]  

Johann P. Schernthaner, Steven F. Fabijanski, Paul G. Arnison, Martine Racicot, and Laurian S. Robert

Control of seed germination in transgenic plants based on the segregation of a two-component genetic system
PNAS 2003 100: 6855-6859; published online before print May 9 2003, 10.1073/pnas.1036833100 [Abstract] [Full Text] [PDF]  

Diego Wengier, Isabel Valsecchi, María Laura Cabanas, Wei-hua Tang, Sheila McCormick, and Jorge Muschietti

The receptor kinases LePRK1 and LePRK2 associate in pollen and when expressed in yeast, but dissociate in the presence of style extract
PNAS 2003 100: 6860-6865; published online before print May 14 2003, 10.1073/pnas.0631728100 [Abstract] [Full Text] [PDF]  

Oliver Laule, Andreas Fürholz, Hur-Song Chang, Tong Zhu, Xun Wang, Peter B. Heifetz, Wilhelm Gruissem, and Markus Lange

Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana
PNAS 2003 100: 6866-6871; published online before print May 14 2003, 10.1073/pnas.1031755100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Jiman Kang and Frank J. Turano

The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana
PNAS 2003 100: 6872-6877; published online before print May 8 200