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COMMENTARIES

Jason Raymond and Robert E. Blankenship

Horizontal gene transfer in eukaryotic algal evolution
PNAS 2003 100: 7419-7420; published online on June 16, 2003, 10.1073/pnas.1533212100 [Extract] [Full Text] [PDF]  
See companion article on page 7678

Helmut Grubmüller

What happens if the room at the bottom runs out? A close look at small water pores
PNAS 2003 100: 7421-7422; published online on June 16, 2003, 10.1073/pnas.1533175100 [Extract] [Full Text] [PDF]  

Zemer Gitai and Lucy Shapiro

Bacterial cell division spirals into control
PNAS 2003 100: 7423-7424; published online on June 16, 2003, 10.1073/pnas.1332806100 [Extract] [Full Text] [PDF]  
See companion article on page 7865

Randolph J. Nudo

Retuning the misfiring brain
PNAS 2003 100: 7425-7427; published online on June 16, 2003, 10.1073/pnas.1533210100 [Extract] [Full Text] [PDF]  
See companion article on page 7942

Rozanne M. Sandri-Goldin

Replication of the herpes simplex virus genome: Does it really go around in circles?
PNAS 2003 100: 7428-7429; published online on June 16, 2003, 10.1073/pnas.1432875100 [Extract] [Full Text] [PDF]  
See companion article on page 7871

Olle Lindvall and Ron McKay

Brain repair by cell replacement and regeneration
PNAS 2003 100: 7430-7431; published online on June 16, 2003, 10.1073/pnas.1332673100 [Extract] [Full Text] [PDF]  
See companion article on page 7925

PHYSICAL SCIENCES

Applied Mathematics

Lawrence Sirovich

A pattern analysis of the second Rehnquist U.S. Supreme Court
PNAS 2003 100: 7432-7437; published online on June 23, 2003, 10.1073/pnas.1132164100 [Abstract] [Full Text] [PDF]  

Applied Physical Sciences

Farren J. Isaacs, Jeff Hasty, Charles R. Cantor, and J. J. Collins

Prediction and measurement of an autoregulatory genetic module
PNAS 2003 100: 7714-7719; published online on June 13, 2003, 10.1073/pnas.1332628100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Geology

Karim Benzerara, Nicolas Menguy, François Guyot, Christian Dominici, and Philippe Gillet

Nanobacteria-like calcite single crystals at the surface of the Tataouine meteorite
PNAS 2003 100: 7438-7442; published online on June 5, 2003, 10.1073/pnas.0832464100 [Abstract] [Full Text] [PDF]  

Statistics

G. A. Held, G. Grinstein, and Y. Tu

Modeling of DNA microarray data by using physical properties of hybridization
PNAS 2003 100: 7575-7580; published online on June 13, 2003, 10.1073/pnas.0832500100 [Abstract] [Full Text] [PDF] [Supporting Information]  

SOCIAL SCIENCES

Anthropology

Camilo J. Cela-Conde and Francisco J. Ayala

Genera of the human lineage
PNAS 2003 100: 7684-7689; published online on June 6, 2003, 10.1073/pnas.0832372100 [Abstract] [Full Text] [PDF]  

Psychology

Michael H. Goldstein, Andrew P. King, and Meredith J. West

Social interaction shapes babbling: Testing parallels between birdsong and speech
PNAS 2003 100: 8030-8035; published online on June 13, 2003, 10.1073/pnas.1332441100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Agricultural Sciences

O. Hanotte, Y. Ronin, M. Agaba, P. Nilsson, A. Gelhaus, R. Horstmann, Y. Sugimoto, S. Kemp, J. Gibson, A. Korol, M. Soller, and A. Teale

Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle
PNAS 2003 100: 7443-7448; published online on June 12, 2003, 10.1073/pnas.1232392100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Applied Biological Sciences

Chunming Ding and Charles R. Cantor

Direct molecular haplotyping of long-range genomic DNA with M1-PCR
PNAS 2003 100: 7449-7453; published online on June 11, 2003, 10.1073/pnas.1232475100 [Abstract] [Full Text] [PDF]  

Biochemistry

Yasuko Nagatsuka, Miki Hara-Yokoyama, Takeshi Kasama, Masataka Takekoshi, Fumiko Maeda, Seiji Ihara, Shigeyoshi Fujiwara, Eriko Ohshima, Kumiko Ishii, Toshihide Kobayashi, Kazufumi Shimizu, and Yoshio Hirabayashi

Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells
PNAS 2003 100: 7454-7459; published online on June 11, 2003, 10.1073/pnas.1232503100 [Abstract] [Full Text] [PDF]  

Hyun Kim, Qi Yan, Gunnar von Heijne, Gregory A. Caputo, and William J. Lennarz

Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae
PNAS 2003 100: 7460-7464; published online on June 16, 2003, 10.1073/pnas.1332735100 [Abstract] [Full Text] [PDF]  

Brian C. Beard, Samuel H. Wilson, and Michael J. Smerdon

Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes
PNAS 2003 100: 7465-7470; published online on June 10, 2003, 10.1073/pnas.1330328100 [Abstract] [Full Text] [PDF]  

Magali Frugier, Richard Giegé, and Paul Schimmel

RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase
PNAS 2003 100: 7471-7475; published online on June 9, 2003, 10.1073/pnas.1332771100 [Abstract] [Full Text] [PDF]  

Thierry Joët, Ursula Eckstein-Ludwig, Christophe Morin, and Sanjeev Krishna

Validation of the hexose transporter of Plasmodium falciparum as a novel drug target
PNAS 2003 100: 7476-7479; published online on June 5, 2003, 10.1073/pnas.1330865100 [Abstract] [Full Text] [PDF]  

Ernie de Boer, Patrick Rodriguez, Edgar Bonte, Jeroen Krijgsveld, Eleni Katsantoni, Albert Heck, Frank Grosveld, and John Strouboulis

Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice
PNAS 2003 100: 7480-7485; published online on June 11, 2003, 10.1073/pnas.1332608100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jackob Moskovitz and Earl R. Stadtman

Selenium-deficient diet enhances protein oxidation and affects methionine sulfoxide reductase (MsrB) protein level in certain mouse tissues
PNAS 2003 100: 7486-7490; published online on June 5, 2003, 10.1073/pnas.1332607100 [Abstract] [Full Text] [PDF]  

Sudipto Das, Jack E. Dixon, and Wonhwa Cho

Membrane-binding and activation mechanism of PTEN
PNAS 2003 100: 7491-7496; published online on June 13, 2003, 10.1073/pnas.0932835100 [Abstract] [Full Text] [PDF]  

Alexei V. Kazantsev, Angelika A. Krivenko, Daniel J. Harrington, Richard J. Carter, Stephen R. Holbrook, Paul D. Adams, and Norman R. Pace

High-resolution structure of RNase P protein from Thermotoga maritima
PNAS 2003 100: 7497-7502; published online on June 10, 2003, 10.1073/pnas.0932597100 [Abstract] [Full Text] [PDF]  

Dahai Xue, Hong Shi, James D. Smith, Xinguo Chen, Dennis A. Noe, Tommy Cedervall, Derek D. Yang, Elizabeth Eynon, Douglas E. Brash, Michael Kashgarian, Richard A. Flavell, and Sandra L. Wolin

A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen
PNAS 2003 100: 7503-7508; published online on June 3, 2003, 10.1073/pnas.0832411100 [Abstract] [Full Text] [PDF]  

Ilana Goldhaber-Gordon, Michael H. Early, and Tania A. Baker

The terminal nucleotide of the Mu genome controls catalysis of DNA strand transfer
PNAS 2003 100: 7509-7514; published online on June 9, 2003, 10.1073/pnas.0832468100 [Abstract] [Full Text] [PDF] [Supporting Materials and Methods]  

Jianqiang Mao, Subrahmanyam S. Chirala, and Salih J. Wakil

Human acetyl-CoA carboxylase 1 gene: Presence of three promoters and heterogeneity at the 5'-untranslated mRNA region
PNAS 2003 100: 7515-7520; published online on June 16, 2003, 10.1073/pnas.1332670100 [Abstract] [Full Text] [PDF]  

Xue-hai Liang, Qing Liu, and Shulamit Michaeli

Small nucleolar RNA interference induced by antisense or double-stranded RNA in trypanosomatids
PNAS 2003 100: 7521-7526; published online on June 13, 2003, 10.1073/pnas.1332001100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Yong Jiang and Russell F. Doolittle

The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes
PNAS 2003 100: 7527-7532; published online on June 13, 2003, 10.1073/pnas.0932632100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jack T. Nguyen and James A. Wells

Direct activation of the apoptosis machinery as a mechanism to target cancer cells
PNAS 2003 100: 7533-7538; published online on June 13, 2003, 10.1073/pnas.1031631100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Annette L. Bodley, Asit K. Chakraborty, Suji Xie, Christian Burri, and Theresa A. Shapiro

An unusual type IB topoisomerase from African trypanosomes
PNAS 2003 100: 7539-7544; published online on June 16, 2003, 10.1073/pnas.1330762100 [Abstract] [Full Text] [PDF]  

Rajat Sapra, Karine Bagramyan, and Michael W. W. Adams

A simple energy-conserving system: Proton reduction coupled to proton translocation
PNAS 2003 100: 7545-7550; published online on June 5, 2003, 10.1073/pnas.1331436100 [Abstract] [Full Text] [PDF]  

Arnold Kristjuhan, Birgitte Ø. Wittschieben, Jane Walker, Douglas Roberts, Bradley R. Cairns, and Jesper Q. Svejstrup

Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation
PNAS 2003 100: 7551-7556; published online on June 9, 2003, 10.1073/pnas.1332299100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Yanhong Ji, Jianmin Zhang, Alfred Ian Lee, Howard Cedar, and Yehudit Bergman

A multistep mechanism for the activation of rearrangement in the immune system
PNAS 2003 100: 7557-7562; published online on June 11, 2003, 10.1073/pnas.0932635100 [Abstract] [Full Text] [PDF] [Supporting Information]  

A. Oganesian, M. Poot, G. Daum, S. A. Coats, M. B. Wright, R. A. Seifert, and D. F. Bowen-Pope

Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation
PNAS 2003 100: 7563-7568; published online on June 11, 2003, 10.1073/pnas.1336511100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Zhen Y. Jiang, Qiong L. Zhou, Kerri A. Coleman, My Chouinard, Queta Boese, and Michael P. Czech

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
PNAS 2003 100: 7569-7574; published online on June 13, 2003, 10.1073/pnas.1332633100 [Abstract] [Full Text] [PDF]  

Biophysics

G. A. Held, G. Grinstein, and Y. Tu

Modeling of DNA microarray data by using physical properties of hybridization
PNAS 2003 100: 7575-7580; published online on June 13, 2003, 10.1073/pnas.0832500100 [Abstract] [Full Text] [PDF] [Supporting Information]  

John van Noort, Thijn van der Heijden, Martijn de Jager, Claire Wyman, Roland Kanaar, and Cees Dekker The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility PNAS 2003 100: 7581-7586; published online on June 12, 2003, 10.1073/pnas.1330706100 [Abstract] [Full Text] [PDF]

Jed W. Pitera and William Swope

Understanding folding and design: Replica-exchange simulations of ``Trp-cage'' miniproteins
PNAS 2003 100: 7587-7592; published online on June 13, 2003, 10.1073/pnas.1330954100 [Abstract] [Full Text] [PDF]  

Carlos J. Bosques and Barbara Imperiali

The interplay of glycosylation and disulfide formation influences fibrillization in a prion protein fragment
PNAS 2003 100: 7593-7598; published online on June 12, 2003, 10.1073/pnas.1232504100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Rommie Amaro, Emad Tajkhorshid, and Zaida Luthey-Schulten

Developing an energy landscape for the novel function of a (/)₈ barrel: Ammonia conduction through HisF
PNAS 2003 100: 7599-7604; published online on June 10, 2003, 10.1073/pnas.1331150100 [Abstract] [Full Text] [PDF]  

Mukta Singh-Zocchi, Sanhita Dixit, Vassili Ivanov, and Giovanni Zocchi

Single-molecule detection of DNA hybridization
PNAS 2003 100: 7605-7610; published online on June 13, 2003, 10.1073/pnas.1337215100 [Abstract] [Full Text] [PDF]  

Daniel Sigg, Francisco Bezanilla, and Enrico Stefani

Fast gating in the Shaker K⁺ channel and the energy landscape of activation
PNAS 2003 100: 7611-7615; published online on June 12, 2003, 10.1073/pnas.1332409100 [Abstract] [Full Text] [PDF]  

Jan Lammerding, Alexander R. Kazarov, Hayden Huang, Richard T. Lee, and Martin E. Hemler

Tetraspanin CD151 regulates 61 integrin adhesion strengthening
PNAS 2003 100: 7616-7621; published online on June 12, 2003, 10.1073/pnas.1337546100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Ole Farver, Peter M. H. Kroneck, Walter G. Zumft, and Israel Pecht

Allosteric control of internal electron transfer in cytochrome cd₁ nitrite reductase
PNAS 2003 100: 7622-7625; published online on June 11, 2003, 10.1073/pnas.0932693100 [Abstract] [Full Text] [PDF]  

Cell Biology

Quan Lu, Lila Weiqiao Hope, Michael Brasch, Christoph Reinhard, and Stanley N. Cohen

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation
PNAS 2003 100: 7626-7631; published online on June 11, 2003, 10.1073/pnas.0932599100 [Abstract] [Full Text] [PDF]  

Sheng Ding, Tom Y. H. Wu, Achim Brinker, Eric C. Peters, Wooyoung Hur, Nathanael S. Gray, and Peter G. Schultz

Synthetic small molecules that control stem cell fate
PNAS 2003 100: 7632-7637; published online on June 6, 2003, 10.1073/pnas.0732087100 [Abstract] [Full Text] [PDF]  

Emmanuelle Six, Delphine Ndiaye, Yacine Laâbi, Christel Brou, Neetu Gupta-Rossi, Alain Israël, and Frédérique Logeat

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and -secretase
PNAS 2003 100: 7638-7643; published online on June 6, 2003, 10.1073/pnas.1230693100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Jason M. Singer and Janet M. Shaw

Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin–actin interactions in budding yeast
PNAS 2003 100: 7644-7649; published online on June 13, 2003, 10.1073/pnas.1232343100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Ecology

Erika S. Zavaleta, M. Rebecca Shaw, Nona R. Chiariello, Harold A. Mooney, and Christopher B. Field

Additive effects of simulated climate changes, elevated CO₂, and nitrogen deposition on grassland diversity
PNAS 2003 100: 7650-7654; published online on June 16, 2003, 10.1073/pnas.0932734100 [Abstract] [Full Text] [PDF]  

Jeyaraney Kathirithamby, Larry D. Ross, and J. Spencer Johnston

Masquerading as self? Endoparasitic Strepsiptera (Insecta) enclose themselves in host-derived epidermal bag
PNAS 2003 100: 7655-7659; published online on June 3, 2003, 10.1073/pnas.1131999100 [Abstract] [Full Text] [PDF]  

Karina J. Nielsen

Nutrient loading and consumers: Agents of change in open-coast macrophyte assemblages
PNAS 2003 100: 7660-7665; published online on June 9, 2003, 10.1073/pnas.0932534100 [Abstract] [Full Text] [PDF]  

Evolution

Katsuhiko Mineta, Masumi Nakazawa, Francesc Cebrià, Kazuho Ikeo, Kiyokazu Agata, and Takashi Gojobori

Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs
PNAS 2003 100: 7666-7671; published online on June 11, 2003, 10.1073/pnas.1332513100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Pavel Pevzner and Glenn Tesler

Human and mouse genomic sequences reveal extensive breakpoint reuse in mammalian evolution
PNAS 2003 100: 7672-7677; published online on June 16, 2003, 10.1073/pnas.1330369100 [Abstract] [Full Text] [PDF] [Supporting Information]  

John M. Archibald, Matthew B. Rogers, Michael Toop, Ken-ichiro Ishida, and Patrick J. Keeling Lateral gene transfer and the evolution of plastid-targeted proteins in the secondary plastid-containing alga Bigelowiella natans PNAS 2003 100: 7678-7683; published online on May 30, 2003, 10.1073/pnas.1230951100 [Abstract] [Full Text] [PDF] [Supporting Information]   See Commentary on page 7419

Camilo J. Cela-Conde and Francisco J. Ayala

Genera of the human lineage
PNAS 2003 100: 7684-7689; published online on June 6, 2003, 10.1073/pnas.0832372100 [Abstract] [Full Text] [PDF]  

Thomas Weber, Martin C. Göpfert, Harald Winter, Ulrike Zimmermann, Hanni Kohler, Alexandra Meier, Oliver Hendrich, Karin Rohbock, Daniel Robert, and Marlies Knipper

Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects
PNAS 2003 100: 7690-7695; published online on June 2, 2003, 10.1073/pnas.1330557100 [Abstract] [Full Text] [PDF]  

Genetics

Stanislav Volik, Shaying Zhao, Koei Chin, John H. Brebner, David R. Herndon, Quanzhou Tao, David Kowbel, Guiqing Huang, Anna Lapuk, Wen-Lin Kuo, Gregg Magrane, Pieter de Jong, Joe W. Gray, and Colin Collins

End-sequence profiling: Sequence-based analysis of aberrant genomes
PNAS 2003 100: 7696-7701; published online on June 4, 2003, 10.1073/pnas.1232418100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Y. Setty, A. E. Mayo, M. G. Surette, and U. Alon

Detailed map of a cis-regulatory input function
PNAS 2003 100: 7702-7707; published online on June 12, 2003, 10.1073/pnas.1230759100 [Abstract] [Full Text] [PDF]  

Tatsuya Anzai, Takashi Shiina, Natsuki Kimura, Kazuyo Yanagiya, Sakae Kohara, Atsuko Shigenari, Tetsushi Yamagata, Jerzy K. Kulski, Taeko K. Naruse, Yoshifumi Fujimori, Yasuhito Fukuzumi, Masaaki Yamazaki, Hiroyuki Tashiro, Chie Iwamoto, Yumi Umehara, Tadashi Imanishi, Alice Meyer, Kazuho Ikeo, Takashi Gojobori, Seiamak Bahram, and Hidetoshi Inoko

Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence
PNAS 2003 100: 7708-7713; published online on June 10, 2003, 10.1073/pnas.1230533100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Farren J. Isaacs, Jeff Hasty, Charles R. Cantor, and J. J. Collins

Prediction and measurement of an autoregulatory genetic module
PNAS 2003 100: 7714-7719; published online on June 13, 2003, 10.1073/pnas.1332628100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Udo Häcker, Sverker Nystedt, Mojgan Padash Barmchi, Carsten Horn, and Ernst A. Wimmer

piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila
PNAS 2003 100: 7720-7725; published online on June 11, 2003, 10.1073/pnas.1230526100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yasunori Sasakura, Satoko Awazu, Shota Chiba, and Nori Satoh

Germ-line transgenesis of the Tc1/mariner superfamily transposon Minos in Ciona intestinalis
PNAS 2003 100: 7726-7730; published online on June 3, 2003, 10.1073/pnas.1230736100 [Abstract] [Full Text] [PDF]  

Eilon Woolf, Cuiying Xiao, Ofer Fainaru, Joseph Lotem, Dalia Rosen, Varda Negreanu, Yael Bernstein, Dalia Goldenberg, Ori Brenner, Gideon Berke, Ditsa Levanon, and Yoram Groner

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis
PNAS 2003 100: 7731-7736; published online on June 9, 2003, 10.1073/pnas.1232420100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Oleg Schmidt-Kittler, Thomas Ragg, Angela Daskalakis, Martin Granzow, Andre Ahr, Thomas J. F. Blankenstein, Manfred Kaufmann, Joachim Diebold, Hans Arnholdt, Peter Müller, Joachim Bischoff, Detlev Harich, Günter Schlimok, Gert Riethmüller, Roland Eils, and Christoph A. Klein

From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression
PNAS 2003 100: 7737-7742; published online on June 13, 2003, 10.1073/pnas.1331931100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Christopher D. Carvin, Archana Dhasarathy, Laurie B. Friesenhahn, Walter J. Jessen, and Michael P. Kladde

Targeted cytosine methylation for in vivo detection of protein–DNA interactions
PNAS 2003 100: 7743-7748; published online on June 13, 2003, 10.1073/pnas.1332672100 [Abstract] [Full Text] [PDF]  

Immunology

Geanncarlo Lugo-Villarino, Roberto Maldonado-López, Richard Possemato, Cristina Peñaranda, and Laurie H. Glimcher

T-bet is required for optimal production of IFN- and antigen-specific T cell activation by dendritic cells
PNAS 2003 100: 7749-7754; published online on June 11, 2003, 10.1073/pnas.1332767100 [Abstract] [Full Text] [PDF]  

Maria Lucchiari-Hartz, Viv Lindo, Niclas Hitziger, Simone Gaedicke, Loredana Saveanu, Peter M. van Endert, Fiona Greer, Klaus Eichmann, and Gabriele Niedermann

Differential proteasomal processing of hydrophobic and hydrophilic protein regions: Contribution to cytotoxic T lymphocyte epitope clustering in HIV-1-Nef
PNAS 2003 100: 7755-7760; published online on June 16, 2003, 10.1073/pnas.1232228100 [Abstract] [Full Text] [PDF]  

Jacqueline R. McDermott, Ruth E. Bartram, Pamela A. Knight, Hugh R. P. Miller, David R. Garrod, and Richard K. Grencis

Mast cells disrupt epithelial barrier function during enteric nematode infection
PNAS 2003 100: 7761-7766; published online on June 9, 2003, 10.1073/pnas.1231488100 [Abstract] [Full Text] [PDF]  

Christoph Wülfing, Bozidar Purtic, Jennifer Klem, and John D. Schatzle

Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing
PNAS 2003 100: 7767-7772; published online on June 11, 2003, 10.1073/pnas.1336920100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Wangsen Cao, Clare Bao, and Charles J. Lowenstein

Inducible nitric oxide synthase expression inhibition by adenovirus E1A
PNAS 2003 100: 7773-7778; published online on June 13, 2003, 10.1073/pnas.1337185100 [Abstract] [Full Text] [PDF]  

Akie Sato, Werner E. Mayer, Peter Overath, and Jan Klein

Genes encoding putative natural killer cell C-type lectin receptors in teleostean fishes
PNAS 2003 100: 7779-7784; published online on June 11, 2003, 10.1073/pnas.1235938100 [Abstract] [Full Text] [PDF]  

Medical Sciences

Jianzhong Huang, Jason S. Frischer, Anna Serur, Angela Kadenhe, Akiko Yokoi, Kimberly W. McCrudden, Tamara New, Kathleen O'Toole, Stephanie Zabski, John S. Rudge, Jocelyn Holash, George D. Yancopoulos, Darrell J. Yamashiro, and Jessica J. Kandel

Regression of established tumors and metastases by potent vascular endothelial growth factor blockade
PNAS 2003 100: 7785-7790; published online on June 12, 2003, 10.1073/pnas.1432908100 [Abstract] [Full Text] [PDF]  

Joe V. Chakkalakal, Mark A. Stocksley, Mary-Ann Harrison, Lindsay M. Angus, Julie Deschênes-Furry, Simon St-Pierre, Lynn A. Megeney, Eva R. Chin, Robin N. Michel, and Bernard J. Jasmin

Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling
PNAS 2003 100: 7791-7796; published online on June 13, 2003, 10.1073/pnas.0932671100 [Abstract] [Full Text] [PDF]  

Lars Zender, Sebastian Hütker, Christian Liedtke, Hans Ludger Tillmann, Steffen Zender, Bettina Mundt, Morlen Waltemathe, Thomas Gösling, Peer Flemming, Nisar Peter Malek, Christian Trautwein, Michael Peter Manns, Florian Kühnel, and Stefan Kubicka

Caspase 8 small interfering RNA prevents acute liver failure in mice
PNAS 2003 100: 7797-7802; published online on June 16, 2003, 10.1073/pnas.1330920100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Lin Pei, Ofer Wiser, Anthony Slavin, David Mu, Scott Powers, Lily Yeh Jan, and Timothy Hoey

Oncogenic potential of TASK3 (Kcnk9) depends on K⁺ channel function
PNAS 2003 100: 7803-7807; published online on June 2, 2003, 10.1073/pnas.1232448100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Bertrand Léobon, Isabelle Garcin, Philippe Menasché, Jean-Thomas Vilquin, Etienne Audinat, and Serge Charpak

Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host
PNAS 2003 100: 7808-7811; published online on June 12, 2003, 10.1073/pnas.1232447100 [Abstract] [Full Text] [PDF]  

Zsuzsa Szondy, Zsolt Sarang, Péter Molnár, Tamás Németh, Mauro Piacentini, Pier Giorgio Mastroberardino, Laura Falasca, Daniel Aeschlimann, Judit Kovács, Ildikó Kiss, Éva Szegezdi, Gabriella Lakos, Éva Rajnavölgyi, Paul J. Birckbichler, Gerry Melino, and László Fésüs

Transglutaminase 2^-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells
PNAS 2003 100: 7812-7817; published online on June 16, 2003, 10.1073/pnas.0832466100 [Abstract] [Full Text] [PDF]  

Minoru Toyota, Yasushi Sasaki, Ayumi Satoh, Kazuhiro Ogi, Takefumi Kikuchi, Hiromu Suzuki, Hiroaki Mita, Nobuyuki Tanaka, Fumio Itoh, Jean-Pierre J. Issa, Kam-Wing Jair, Kornel E. Schuebel, Kohzoh Imai, and Takashi Tokino

Epigenetic inactivation of CHFR in human tumors
PNAS 2003 100: 7818-7823; published online on June 16, 2003, 10.1073/pnas.1337066100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tao Su, Masumi Suzui, Lei Wang, Chyuan-Sheng Lin, Wang-Qiu Xing, and I. Bernard Weinstein

Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis
PNAS 2003 100: 7824-7829; published online on June 16, 2003, 10.1073/pnas.1332160100 [Abstract] [Full Text] [PDF]  

John H. Griffin, Joey Leung, Rebecca J. Bruner, Michael A. Caligiuri, and Roger Briesewitz

Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome
PNAS 2003 100: 7830-7835; published online on June 13, 2003, 10.1073/pnas.0932698100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Ken-Ichi Imadome, Masaki Shirakata, Norio Shimizu, Shigeaki Nonoyama, and Yuji Yamanashi

CD40 ligand is a critical effector of Epstein–Barr virus in host cell survival and transformation
PNAS 2003 100: 7836-7840; published online on June 12, 2003, 10.1073/pnas.1231363100 [Abstract] [Full Text] [PDF]  

Pradip K. Majumder, Jen Jen Yeh, Daniel J. George, Phillip G. Febbo, Jennifer Kum, Qi Xue, Rachel Bikoff, Hongfeng Ma, Philip W. Kantoff, Todd R. Golub, Massimo Loda, and William R. Sellers

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
PNAS 2003 100: 7841-7846; published online on June 10, 2003, 10.1073/pnas.1232229100 [Abstract] [Full Text] [PDF] [HTML Page - index.htslp]  

Michael L. Cher, Hector R. Biliran, Jr., Sunita Bhagat, Yonghong Meng, Mingxin Che, Jaron Lockett, Judith Abrams, Rafael Fridman, Michael Zachareas, and Shijie Sheng

Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis
PNAS 2003 100: 7847-7852; published online on June 3, 2003, 10.1073/pnas.1331360100 [Abstract] [Full Text] [PDF]  

T. Rozovskaia, O. Ravid-Amir, S. Tillib, G. Getz, E. Feinstein, H. Agrawal, A. Nagler, E. F. Rappaport, I. Issaeva, Y. Matsuo, U. R. Kees, T. Lapidot, F. Lo Coco, R. Foa, A. Mazo, T. Nakamura, C. M. Croce, G. Cimino, E. Domany, and E. Canaani

Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements
PNAS 2003 100: 7853-7858; published online on June 2, 2003, 10.1073/pnas.1132115100 [Abstract] [Full Text] [PDF] [Supporting Information]  

María Elena Martínez, Thomas G. O'Brien, Kimberly E. Fultz, Naveen Babbar, Hagit Yerushalmi, Ning Qu, Yongjun Guo, David Boorman, Janine Einspahr, David S. Alberts, and Eugene W. Gerner

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene
PNAS 2003 100: 7859-7864; published online on June 16, 2003, 10.1073/pnas.1332465100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Microbiology

Sara A. Jackson and Neal A. DeLuca

Relationship of herpes simplex virus genome configuration to productive and persistent infections
PNAS 2003 100: 7871-7876; published online on June 9, 2003, 10.1073/pnas.1230643100 [Abstract] [Full Text] [PDF]  
See Commentary on page 7428

Thierry Garnier, Karin Eiglmeier, Jean-Christophe Camus, Nadine Medina, Huma Mansoor, Melinda Pryor, Stephanie Duthoy, Sophie Grondin, Celine Lacroix, Christel Monsempe, Sylvie Simon, Barbara Harris, Rebecca Atkin, Jon Doggett, Rebecca Mayes, Lisa Keating, Paul R. Wheeler, Julian Parkhill, Bart G. Barrell, Stewart T. Cole, Stephen V. Gordon, and R. Glyn Hewinson

The complete genome sequence of Mycobacterium bovis
PNAS 2003 100: 7877-7882; published online on June 3, 2003, 10.1073/pnas.1130426100 [Abstract] [Full Text] [PDF]  

Víctor Parro and Mercedes Moreno-Paz

Gene function analysis in environmental isolates: The nif regulon of the strict iron oxidizing bacterium Leptospirillum ferrooxidans
PNAS 2003 100: 7883-7888; published online on June 13, 2003, 10.1073/pnas.1230487100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Suzanne C. Cordell, Elva J. H. Robinson, and Jan Löwe

Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ
PNAS 2003 100: 7889-7894; published online on June 13, 2003, 10.1073/pnas.1330742100 [Abstract] [Full Text] [PDF]  

Daniel D. Pinschewer, Mar Perez, Ana B. Sanchez, and Juan Carlos de la Torre

Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein
PNAS 2003 100: 7895-7900; published online on June 13, 2003, 10.1073/pnas.1332709100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sebastian Suerbaum, Christine Josenhans, Torsten Sterzenbach, Bernd Drescher, Petra Brandt, Monica Bell, Marcus Dröge, Berthold Fartmann, Hans-Peter Fischer, Zhongming Ge, Andrea Hörster, Rudi Holland, Kerstin Klein, Jochen König, Ludwig Macko, George L. Mendz, Gerald Nyakatura, David B. Schauer, Zeli Shen, Jacqueline Weber, Matthias Frosch, and James G. Fox

The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
PNAS 2003 100: 7901-7906; published online on June 16, 2003, 10.1073/pnas.1332093100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Daniel J. Wozniak, Timna J. O. Wyckoff, Melissa Starkey, Rebecca Keyser, Parastoo Azadi, George A. O'Toole, and Matthew R. Parsek

Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms
PNAS 2003 100: 7907-7912; published online on June 16, 2003, 10.1073/pnas.1231792100 [Abstract] [Full Text] [PDF]  

Gil Ben-Menachem, Joanna Kubler-Kielb, Bruce Coxon, Alfred Yergey, and Rachel Schneerson

A newly discovered cholesteryl galactoside from Borrelia burgdorferi
PNAS 2003 100: 7913-7918; published online on June 10, 2003, 10.1073/pnas.1232451100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neuroscience

Daniel G. Herrera, Almudena G. Yagüe, Siv Johnsen-Soriano, Francisco Bosch-Morell, Lucía Collado-Morente, Maria Muriach, Francisco J. Romero, and J. Manuel García-Verdugo

Selective impairment of hippocampal neurogenesis by chronic alcoholism: Protective effects of an antioxidant
PNAS 2003 100: 7919-7924; published online on June 5, 2003, 10.1073/pnas.1230907100 [Abstract] [Full Text] [PDF]  

Ming Zhao, Stefan Momma, Kioumars Delfani, Marie Carlén, Robert M. Cassidy, Clas B. Johansson, Hjalmar Brismar, Oleg Shupliakov, Jonas Frisén, and Ann Marie Janson Evidence for neurogenesis in the adult mammalian substantia nigra PNAS 2003 100: 7925-7930; published online on June 5, 2003, 10.1073/pnas.1131955100 [Abstract] [Full Text] [PDF] [Supporting Movie]   See Commentary on page 7430